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La douleur dans la dépression majeure : de l’évidence clinique au paradoxe expérimental

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Book cover Santé mentale et douleur
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Résumé

Plusieurs études ont mis en relief des relations réciproques entre la douleur et la dépression, mais la nature complexe de ces relations demeure incomprise. Les évidences empiriques suggèrent que la douleur chronique est un facteur de risque de la dépression majeure (DM), et inversement, que les symptômes dépressifs augmentent le risque de développer des douleurs chroniques, bien que la douleur chronique semble davantage mener à la dépression que la DM à la douleur chronique [1] (voir les études épidémiologiques, chapitre 4). Plus de 50 % des patient(e)s avec la DM ressentent des symptômes somatiques, telles que les céphalées, les douleurs musculosquelettiques (exemple :dos) et les douleurs viscérales (abdominales) [2, 3]. Les symptômes douloureux dans la DM ont été associés é des symptômes dépressifs plus sévères, un statut fonctionnel plus faible, une qualité de vie et une santé plus pauvres, surtout lorsque la douleur est diffuse [4, 5]. Réciproquement, les symptômes dépressifs chez les personnes souffrant de douleurs chroniques ont un pronostic plus défavorable, incluant des douleurs plus intenses, plus durables et un plus grand recours aux soins de santé [4].

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Références

  1. Fishbain D, Cutler R, Rosomoff H et al. (1997) Chronic pain-associated depression: antecedent or consequence of chronic pain? A review. Clin J Pain 13: 116–137

    Article  PubMed  CAS  Google Scholar 

  2. Garcia-Cebrian A, Gandhi P, Demyttenaere K et al. (2006) The association of depression and painful physical symptoms — a review of the European literature. Eur Psychiatry 21: 379–388

    Article  PubMed  CAS  Google Scholar 

  3. Stahl S, Briley M (2004) Understanding pain in depression. Hum Psychopharmacol 19: S9–S13

    Article  PubMed  Google Scholar 

  4. Bair MJ, Robinson RL, Katon W et al. (2003) Depression and pain comorbidity: a literature review. Arch Int Med 163: 2433–2445

    Article  Google Scholar 

  5. Von Korff M, Simon G (1996) The relationship between pain and depression. Brit J Psychiatry Suppl 30: 101–108

    Google Scholar 

  6. Berna C, Leknes S, Holmes EA et al. (2010) Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness. Biol Psychiatry 67: 1083–1090

    Article  PubMed  Google Scholar 

  7. Carter LE, McNeil DW, Vowles KE et al. (2002) Effects of emotion on pain reports, tolerance and physiology. Pain Res Manag 7: 21–29

    PubMed  Google Scholar 

  8. Loggia ML, Mogil JS, Bushnell MC (2008) Experimentally induced mood changes preferentially affect pain unpleasantness. J Pain 9: 784–791

    Article  PubMed  Google Scholar 

  9. Rainville, P, Bao QVH, Chrétien P (2005) Pain-related emotions modulate experimental pain perception and autonomic responses. Pain 118: 306–318

    Article  PubMed  Google Scholar 

  10. Terhaar J, Boettger MK, Schwier C et al. (2010) Increased sensitivity to heat pain after sad mood induction in female patients with major depression. Eur J Pain 14: 559–563

    Article  PubMed  Google Scholar 

  11. Weisenberg M, Raz T, Hener T (1998) The influence of film-induced mood on pain perception. Pain 76: 365–375

    Article  PubMed  CAS  Google Scholar 

  12. Boettger MK, Greiner W, Rachow T et al. (2010) Sympathetic skin response following painful electric stimulation is increased in major depression. Pain 149: 130–134

    Article  PubMed  Google Scholar 

  13. Dworkin RH, Clark CW, Lipsitz JD (1995) Pain responsivity in major depression and bipolar disorder. Psychiatry Res 56: 173–181

    Article  PubMed  CAS  Google Scholar 

  14. Wang W, Fu XM, Wang YH (2000) Temporalis exteroceptive suppression in generalized anxiety disorder and major depression. Psychiatry Res 96: 149–155

    Article  PubMed  CAS  Google Scholar 

  15. Gormsen L, Ribe AR, Ran P et al. (2004) Pain thresholds during and after treatment of severe depression with electroconvulsive therapy. Eur J Pain 8: 487–493

    Article  PubMed  Google Scholar 

  16. Strigo IA, Simmons AN, Matthews SC et al. (2008a) Increased affective bias revealed using experimental graded heat stimuli in young depressed adults: evidence of “emotional allodynia”. Psychosom Med 70: 338–344

    Article  PubMed  Google Scholar 

  17. Dickens C, McGowan L, Dale S (2003) Impact of depression on experimental pain perception: a systematic review of the literature with meta-analysis. Psychosomatic Med 65: 369–375

    Article  Google Scholar 

  18. Lautenbacher S, Spernal J, Schreiber W et al. (1999) Relationship between clinical pain complaints and pain sensitivity in patients with depression and panic disorder. Psychsomatic Med 61: 822–827

    CAS  Google Scholar 

  19. Lautenbacher S, Roscher S, Strian D et al. (1994) Pain perception in depression: relationships to symptomatology and naloxone-sensitive mechanisms. Psychosomatic Med 56: 345–352

    CAS  Google Scholar 

  20. Celada P, Puig M, Amargos-Bosch M et al. (2004) The therapeutic role of 5-HT1A and 5-HT2A receptors in depression. J Psychiatry Neurosci 29: 252–265

    PubMed  Google Scholar 

  21. Meyer JH (2007) Imaging the serotonin transporter during major depressive disorder and antidepressant treatment. J Psychiatry Neurosci 32: 86–102

    PubMed  Google Scholar 

  22. Le Bars D, Dickenson AH, Besson JM (1979a) Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat. Pain 6: 283–304

    Article  PubMed  Google Scholar 

  23. Le Bars D, Dickenson AH, Besson JM (1979b) Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications. Pain 6: 305–327

    Article  PubMed  Google Scholar 

  24. Millan MJ (2002) Descending control of pain. Prog Neurobiol 66: 355–474

    Article  PubMed  CAS  Google Scholar 

  25. Bär KJ., Greiner W, Letsch A et al. (2003) Influence of gender and hemispheric lateralization on heat pain perception in major depression. J Psychiatr Res 37: 345–353

    Article  PubMed  Google Scholar 

  26. Normand E, Potvin S, Corbin JF, et al. (2011) Marchand S. Pain inhibition is deficient in chronic widespread pain but normal in major depressive disorder. J Clin Psychiatry 72(2): 219–224

    Article  PubMed  Google Scholar 

  27. Katona C, Peveler R, Dowrick C et al. (2005) Pain symptoms in depression: definition and clinical significance. Clin Med 5: 390–395

    PubMed  Google Scholar 

  28. Campbell LC, Clauw DJ, Keefe FJ (2003) Persistent pain and depression: a biopsychosocial perspective. Biol. Psychiatry 54: 399–409

    Article  PubMed  Google Scholar 

  29. Strigo IA, Simmons AN, Matthews SC et al. (2008b) Major depressive disorder is associated with altered functional brain response during anticipation and processing of heat pain. Arch Gen Psychiatry 65: 1275–1284

    Article  PubMed  Google Scholar 

  30. Adler G, Gattaz WF (1993) Pain perception threshold in major depression. Biol Psychiatry 34: 687–689

    Article  PubMed  CAS  Google Scholar 

  31. Marazziti D, Castrogiovanni P, Rossi A et al. (1998) Pain threshold is reduced in depression. Int J Neuropsychopharmacology 1: 45–48

    Article  Google Scholar 

  32. Bär KJ, Terhaar J, Boeetger MK et al. (2011) Pseudohypoalgesia on the skin: a novel view on the paradox of pain perception in depression. J Clin Psychopharmacol 31: 103–107

    Article  PubMed  Google Scholar 

  33. Bär KJ, Wagner G, Koschke M et al. (2007) Increased prefrontal activation during pain perception in major depression. Biol Psychiatry 62: 1281–1287

    Article  PubMed  Google Scholar 

  34. Bär KJ, Brehm S, Boettger MK et al. (2005) Pain perception in major depression depends on pain modality. Pain 117: 95–103

    Article  Google Scholar 

  35. Schwier C, Kliem A, Boettger MK et al. (2010) Increased col-pain thresholds in major depression. J Pain 11: 287–290

    Article  PubMed  Google Scholar 

  36. Spernal J, Krieg JC, Lautenbacher S (2003) Pain thresholds as a putative functional test for cerebral laterality in major depressive disorder and panic disorder. Neuropsychobiology 48: 146–151

    Article  PubMed  Google Scholar 

  37. Frew AK, Drummond PD (2009) Opposite effects of opioid blockade on the blood pressure-pain relationship in depressed and non-depressed participants. Pain 142: 68–74

    Article  PubMed  CAS  Google Scholar 

  38. Lopez-Sola M, Pujol J, Hernandez-Ribas R et al. (2010) Effects of duloxetine treatment on brain response to painful stimulation in major depressive disorder. Neuropsychopharmacology 35: 2305–2317

    Article  PubMed  CAS  Google Scholar 

  39. Bruder GE, Fong R, Tenke CE et al. (1997) Regional brain asymmetries in major depression with or without an anxiety disorder: a quantitative electroencephalographic study. Biol Psychiatry 41: 939–948

    Article  PubMed  CAS  Google Scholar 

  40. Lacerda ALT, Nicoletti MA, Brambilla P et al. (2003) Anatomical MRI study of basal ganglia in major depressive disorder. Psychiatry Res 124: 129–140

    Article  PubMed  Google Scholar 

  41. Vythilingam M, Charles CH, Tupler LA et al. (2003) Focal and lateralized subcortical abnormalities in unipolar major depressive disorder. Biol Psychiatry 54: 744–750

    Article  PubMed  Google Scholar 

  42. Kleinböhl D, Hölzl R, Möltner, A et al. (1999) Psychophysical measures of sensitization to tonic heat discriminate chronic pain patients. Pain 81: 35–43

    Article  PubMed  Google Scholar 

  43. Micalos PS, Drinkwater EJ, Cannon J et al. (2009) Reliability of the nociceptive flexor reflex (RIII) threshold and association with pain threshold. Eur J Appl Physiol 105: 55–62

    Article  PubMed  Google Scholar 

  44. Verdu B, Decosterd I, Buclin T et al. (2008) Antidepressants for the treatment of chronic pain. Drugs 68: 2611–2632

    Article  PubMed  CAS  Google Scholar 

  45. Potvin S, Marchand S (2008) Hypoalgesia in schizophrenia is independent of antipsychotic drugs: a systematic quantitative review of experimental studies. Pain 138: 70–78

    Article  PubMed  CAS  Google Scholar 

  46. Schmahl C, Greffrath W, Baumgärtner U et al. (2004) Differential nociceptive deficits in patients with borderline personality disorder and self-injurious behavior: laser-evoked potentials, spatial discrimination of noxious stimuli, and pain ratings. Pain 110: 470–479

    Article  PubMed  Google Scholar 

  47. Large, M, Babidge N, Andrews D et al. (2009) Major self-stimulation in first episode of psychosis. Schizophr Bull 35: 1012–1021

    Article  PubMed  Google Scholar 

  48. Orbach I, Mikulincer M, King R et al. (1997) Thresholds and tolerance of physical pain in suicidal and nonsuicidal adolescents. J Consult Clin Psychol 65: 646–652

    Article  PubMed  CAS  Google Scholar 

  49. Pinerua-Shuhaibar L, Prieto-Rincon D, Ferrer A et al. (1999) Reduced tolerance and cardiovascular response to ischemic pain in minor depression. J Affect Disord 56: 119–126

    Article  PubMed  CAS  Google Scholar 

  50. Koseka E, Hanssonb P (1997) Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects. Pain 70: 41–51

    Article  Google Scholar 

  51. Forkmann T, Heins M, Bruns T et al. (2009) The second exteroceptive suppression is affected by psychophysiological factors. J Psychosom Res 66: 521–529

    Article  PubMed  Google Scholar 

  52. Klauenberg S, Maier C, Assion HJ et al. (2008) Depression and changed perception: hints for a central disinhibition mechanism. Pain 140: 332–343

    Article  PubMed  Google Scholar 

  53. Fillingim RB, King CD, Ribeiro-Dasilva MC et al. (2009) Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain 10: 447–485

    PubMed  Google Scholar 

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Potvin, S. (2013). La douleur dans la dépression majeure : de l’évidence clinique au paradoxe expérimental. In: Santé mentale et douleur. Springer, Paris. https://doi.org/10.1007/978-2-8178-0307-4_6

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  • DOI: https://doi.org/10.1007/978-2-8178-0307-4_6

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0306-7

  • Online ISBN: 978-2-8178-0307-4

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