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Utilisation des biomarqueurs en pédiatrie

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Les biomarqueurs en médecine d’urgence

Résumé

L’utilisation des biomarqueurs en pédiatrie est une pratique ancienne et courante. En effet, le manque de spécificité des signes cliniques chez l’enfant, en particulier d’âge préverbal, rend parfois peu informatif l’examen clinique. Les notions de céphalées, photophobies, douleurs lombaires, thoraciques ou encore de courbatures par exemple sont autant d’éléments d’orientation précieux chez le sujet adulte, mais qui font défaut chez le jeune enfant. Il est classique de constater que la sémiologie est d’autant moins évidente que l’enfant est jeune, l’examen dans les premiers mois de vie étant particulièrement difficile. On conçoit dans ce contexte l’importance que peuvent revêtir les biomarqueurs, qui sont utilisés comme des « compléments » diagnostiques de l’examen clinique et apportent au clinicien au lit du malade une aide précieuse au quotidien.

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Références

  1. Craig JC, Williams GJ, Jones M, et al. (2010) The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses. BMJ 20: cl594

    Google Scholar 

  2. Manzano S, Bailey B, Gervaix A, et al. (2011) Markersfor bacterial infection in children with fever without source. Arch Dis Child 96: 440–446

    Article  PubMed  Google Scholar 

  3. Herd D (2007) In children under age three does procalcitonin help exclude serious bacterial infection in fever without focus? Arch Dis Child 92: 362–364

    Article  PubMed  Google Scholar 

  4. Galetto-Lacour A, Zamora SA, Andreola B, et al. (2010) Validation of a laboratory risk index score for the identification of severe bacterial infection in children with fever without source. Arch Dis Child 95: 968–973

    Article  PubMed  Google Scholar 

  5. Dubos F, Martinot A, Gendrel D, et al. (2009) Clinical decision rules for evaluating meningitis in children. Curr Opin Neurol 22: 288–293

    Article  PubMed  Google Scholar 

  6. Dubos F, Korczowski B, Aygun DA, et al. (2010) Distinguishing between bacterial and aseptic meningitis in children:European comparison of two clinical decision rules. Arch Dis Child 95: 963–967

    Article  PubMed  Google Scholar 

  7. Nigrovic LE, Kuppermann N, Macias CG, et al. (2007) Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. JAMA 297: 52–60

    Article  PubMed  CAS  Google Scholar 

  8. Dubos F, Moulin F, Gendel D, et al. (2008) Distinguishing between bacterial and aseptic meningitis in children. Arch Pediatr 15: 724–725

    Article  PubMed  CAS  Google Scholar 

  9. Lorrot M, Fitoussi F, Faye A, et al. (2007) Laboratory studies in pediatric bone and joint infections. Arch Pediatr 14Suppl 2: S86–90

    Article  PubMed  Google Scholar 

  10. Unkila-Kallio L, Kallio MJ, Eskola J, et al. (1994) Serum C-reactive protein, erythrocyte sedimentation rate, and white blood cell count in acute hematogenous osteomyelitis of children. Pediatrics 93: 59–62

    PubMed  CAS  Google Scholar 

  11. Harris JC, Caesar DH, Davison C, et al. (2011) How useful are laboratory investigations in the emergency department evaluation of possible osteomyelitis? Emerg Med Australas 23: 317–330

    Article  PubMed  Google Scholar 

  12. Paakkonen M, Kallio MJ, Kallio PE, et al. (2010) Sensitivity of erythrocyte sedimentation rate and C-reactive protein in childhood bone and joint infections. Clin Orthop Relat Res 468: 861–866

    Article  PubMed  Google Scholar 

  13. Kocher MS, Mandiga R, Zurakowski D, et al. (2004) Validation of a clinical prediction rule for the differentiation between septic arthritis and transient synovitis of the hip in children. J Bone Joint Surg Am 86-A: 1629–1635

    PubMed  Google Scholar 

  14. Hariharan P, Kabrhel C (2011) Sensitivity of erythrocyte sedimentation rate and C-reactive protein for the exclusion of septic arthritis in emergency department patients. J Emerg Med 40: 428–431

    Article  PubMed  Google Scholar 

  15. Singhal R, Perry DC, Khan FN, et al. (2011) The use of CRP within a clinical prediction algorithm for the differentiation of septic arthritis and transient synovitis in children. J Bone Joint Surg Br 93: 1556–1561

    Article  PubMed  CAS  Google Scholar 

  16. Butbul-Aviel Y, Koren A, Halevy R, et al. (2005) Procalcitonin as a diagnostic aid in osteomyelitis and septic arthritis. Pediatr Emerg Care 21: 828–832

    Article  PubMed  Google Scholar 

  17. Leroy S, Romanello C, Galetto-Lacour A, et al. (2011) Procalcitonin is a predictor for high-grade vesicoureteral reflux in children: meta-analysis of individual patient data. J Pediatr 159: 644–651

    Article  PubMed  CAS  Google Scholar 

  18. Leroy S, Romanello C, Smolkin V, et al. (2012) Prediction of moderate and high grade vesicoureteral reflux after a first febrile urinary tract infection in children: construction and internal validation of a clinical decision rule. J Urol 187: 265–271

    PubMed  Google Scholar 

  19. Leroy S, Bouissou F, Fernandez-Lopez A, et al. (2011) Prediction of high-grade vesicoureteral reflux after pediatric urinary tract infection: external validation study of procalcitonin-based decision rule. PLoS One. 6: e29556

    Article  PubMed  CAS  Google Scholar 

  20. Al-Ismaili Z, Palijan A, Zappitelli M (2011) Biomarkers of acute kidney injury in children: discovery, evaluation, and clinical application. Pediatr Nephrol 26: 29–40

    Article  PubMed  Google Scholar 

  21. Du Y, Zappitelli M, Mian A, et al. (2011) Urinary biomarkers to detect acute kidney injury in the pediatric emergency center. Pediatr Nephrol 26: 267–274

    Article  PubMed  Google Scholar 

  22. Moulin F, Raymond J, Lorrot M, et al. (2001) Procalcitonin in children admitted to hospital with community acquired pneumonia. Arch Dis Child 84: 332–326

    Article  PubMed  CAS  Google Scholar 

  23. Khan DA, Rahman A, Khan FA (2010) Is procalcitonin better than C-reactive protein for early diagnosis of bacterial pneumonia in children? J Clin Lab Anal 24: 1–5

    Article  PubMed  CAS  Google Scholar 

  24. Toikka P, Irjala K, Juvén T, et al. (2000) Serum procalcitonin, C-reactive protein and interleukin-6 for distinguishing bacterial and viral pneumonia in children. Pediatr Infect Dis J 19: 598–602

    Article  PubMed  CAS  Google Scholar 

  25. Nascimento-Carvalho CM, Cardoso MR, Barrai A, et al. (2010) Procalcitonin is useful in identifying bacteraemia among children with pneumonia. Scand J Infect Dis 42: 644–649

    Article  PubMed  CAS  Google Scholar 

  26. Müller F, Christ-Crain M, Bregenzer T, et al. (2010) Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial. Chest 138: 121–129

    Article  PubMed  Google Scholar 

  27. Gendrel D, Vallet C, Gelmetti C, et al. (2010) Pneumococcal pneumonia highly probable in immunized children cared for in-group settings. Arch Pediatr 17: 373–377

    Article  PubMed  CAS  Google Scholar 

  28. Wang LT, Prentiss KA, Simon JZ, et al. (2007) The use of white blood cell count and left shift in the diagnosis of appendicitis in children. Pediatr Emerg Care 23: 69–76

    Article  PubMed  Google Scholar 

  29. Kwan KY, Nager AL (2010) Diagnosing pediatric appendicitis: usefulness of laboratory markers. Am J Emerg Med 28: 1009–1015

    Article  PubMed  Google Scholar 

  30. Bundy DG, Byerley JS, Liles EA, et al. (2007) Does this child have appendicitis? JAMA 298: 438–451

    Article  PubMed  CAS  Google Scholar 

  31. Kharbanda AB, Cosme Y, Liu K, et al. (2011) Discriminative accuracy of novel and traditional biomarkers in children with suspected appendicitis adjusted for duration of abdominal pain. Acad Emerg Med 18: 567–574

    Article  PubMed  Google Scholar 

  32. Sack U, Biereder B, Elouahidi T, et al. (2006) Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children. BMC Surg 6: 15

    Article  PubMed  Google Scholar 

  33. Allister L, Bachur R, Glickman J, Horwitz B (2011) Serum markers in acute appendicitis. J Surg Res 168: 70–75

    Article  PubMed  CAS  Google Scholar 

  34. Kafetzis DA, Velissariou IM, Nikolaides P, et al. (2005) Procalcitonin as a predictor of severe appendicitis in children. Eur J Clin Microbiol Infect Dis 24: 484–487

    Article  PubMed  CAS  Google Scholar 

  35. Sand M, Trullen XV, Bechara FG, et al. (2009) A prospective bicenter study investigating the diagnostic value of procalcitonin in patients with acute appendicitis. Eur Surg Res 43: 291–297

    Article  PubMed  CAS  Google Scholar 

  36. Crowe L, Babl F, Anderson V, Catroppa C (2009) The epidemiology of paediatric head injuries: Data from a referral centre in Victoria, Australia. J Paediatr Child Health

    Google Scholar 

  37. Kuppermann N, Holmes JF, Dayan PS, et al. (2009) Pediatric Emergency Care Applied Research Network (PECARN). Lancet 374: 1160–1170

    Article  PubMed  Google Scholar 

  38. Biberthaler P, Mussack T, Wiedemann E, et al. (2001) Evaluation of S-100b as a specific marker for neuronal damage due to minor head trauma. World J Surg 25: 93–97

    Article  PubMed  CAS  Google Scholar 

  39. Ruan S, Noyes K, Bazarian JJ (2009) The economic impact of S-100B as a pre-head CT screening test on emergency department management of adult patients with mild traumatic brain injury. J Neurotrauma 26: 1655–1664

    Article  PubMed  Google Scholar 

  40. Hallén M, Karlsson M, Carlhed R, et al. (2010) S-100B in serum and urine after traumatic head injury in children. J Trauma 69: 284–289

    Article  PubMed  Google Scholar 

  41. Müller K, Townend W, Biasca N, et al. (2007) S100B serum level predicts computed tomography findings after minor head injury. J Trauma 62: 1452–1456

    Article  PubMed  Google Scholar 

  42. Castellani C, Bimbashi P, Ruttenstock E, et al. (2009) Neuroprotein s-100B-a useful parameter in paediatric patients with mild traumatic brain injury? Acta Paediatr 98: 1607–1612

    Article  PubMed  CAS  Google Scholar 

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Gras-Le Guen, C., Vrignaud, B., Levieux, K., Lalande, J., Humbert, J., Launay, E. (2012). Utilisation des biomarqueurs en pédiatrie. In: Claessens, YÉ., Ray, P. (eds) Les biomarqueurs en médecine d’urgence. Références en médecine d’urgence. Collection de la SFMU. Springer, Paris. https://doi.org/10.1007/978-2-8178-0297-8_36

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  • DOI: https://doi.org/10.1007/978-2-8178-0297-8_36

  • Publisher Name: Springer, Paris

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  • Online ISBN: 978-2-8178-0297-8

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