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La NGAL: Neutrophil Gelatinase-Associated Lipocalin

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Les biomarqueurs en médecine d’urgence

Part of the book series: Références en médecine d’urgence. Collection de la SFMU ((REFERMED))

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Résumé

La Neutrophil Gelatinase-Associated Lipocalin (NGAL) aussi appelée sidérocaline ou lipocaline 2 est une glycoprotéine de 25 kilodaltons (kDa) appartenant à la superfamille des lipocalines, capables de fixer des molécules hydrophobes diverses mais aussi le fer. Initialement identifiée par Triebel en 1992 dans le surnageant de polynucléaires activés, la NGAL a ensuite été mise en évidence dans de nombreux tissus et plus particulièrement dans les cellules tubulaires proximales du rein. L’une de ses fonctions biologiques les plus importantes semble être l’inhibition de la croissance bactérienne. Cette protéine est aussi fortement impliquée dans le développement du rein in utero mais aussi dans son fonctionnement à l’état adulte.

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Références

  1. Bundgaard JR, Sengelov H, Borregaard N, Kjeldsen L (1994) Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils. Biochem. Biophys Res Commun 202: 1468–1475

    Article  PubMed  CAS  Google Scholar 

  2. Mishra J, Dent C, Tarabishi R, et al. (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365: 1231–1238

    Article  PubMed  CAS  Google Scholar 

  3. Constantin JM, Futier E, Perbet S, et al. (2010) Plasma neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in adult critically ill patients: a prospective study. J Crit Care 25: 176. el-6

    Article  PubMed  Google Scholar 

  4. Devarajan P (2010) Review: neutrophil gelatinase-associated lipocalin: a troponin-like biomarker for human acute kidney injury. Nephrology (Carlton) 15:419–428

    Article  Google Scholar 

  5. Hazem A, Seham B, Eman O, et al. (2007) Serum and urinary NGAL in acute and chronic kidney disease. Kidney Int 71: 967–970

    Article  Google Scholar 

  6. Nielsen SE, Hansen HP, Jensen BR, et al. (2011) Urinary neutrophil gelatinase-associated lipocalin and progression of diabetic nephropathy in type 1 diabetic patients in a four-year follow-up study. Nephron Clin Pract 118: c130–135

    Article  PubMed  CAS  Google Scholar 

  7. Roszyk L, Constantin JM (2010) NGAL: neutrophil gelatinase-associated lipocalin, siderocalin, lipocalin 2. EMC, Biologie Clinique 90-0663

    Google Scholar 

  8. Gaspari F, Cravedi P, Mandalà M, et al. (2010) Predicting cisplatin-induced acute kidney injury by urinary neutrophil gelatinase-associated lipocalin excretion: a pilot prospective case-control study. Nephron Clin Pract 115: c154–160

    Article  PubMed  CAS  Google Scholar 

  9. Hirsch R, Dent C, Pfriem H, et al. (2007) NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Pediatr Nephrol 22: 2089–2095

    Article  PubMed  Google Scholar 

  10. Koura HM, Galal A, Elshamma MF, et al. (2011) Urinary neutrophil gelatinase-associated lipocalin as a marker of disease activity in patients with lupus nephritis. Int J Acad Res 3: 141–146

    Google Scholar 

  11. D’Anna R, Baviera G, Giordano D, et al. (2008) Second trimester neutrophil gelatinase-associated lipocalin as a potential prediagnostic marker of preeclampsia. Acta Obstet Gynecol Scand 87: 1370–1373

    Article  PubMed  Google Scholar 

  12. Bennett M, Dent CL, Ma Q, et al. (2008) Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study. Clin J Am Soc Nephrol 3: 665–673

    Article  PubMed  Google Scholar 

  13. Nickolas TL, O’Rourke MJ, Yang J, et al. (2008) Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med 148: 810–819

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Biochimie médicale, CHU Estaing, Place Lucie-Aubrac, 63000, Clermont-Ferrand, France

    V. Sapin & L. Roszyk

  2. Anesthésie-Réanimation, CHU Estaing, Place Lucie-Aubrac, 63000, Clermont-Ferrand, France

    J.-M. Constantin

Authors
  1. V. Sapin
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  2. L. Roszyk
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  3. J.-M. Constantin
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Editor information

Editors and Affiliations

  1. Département de médecine d’urgence, Centre hospitalier Princesse Grace, 1, avenue Pasteur, BP 489, MC-98012, Monaco

    Yann-Érick Claessens

  2. Hôpital Tenon Service d’accueil des urgences, UPMC-Paris 6, 4, rue de la Chine, 75020, Paris, France

    Patrick Ray

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© 2012 Springer-Verlag France, Paris

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Sapin, V., Roszyk, L., Constantin, JM. (2012). La NGAL: Neutrophil Gelatinase-Associated Lipocalin . In: Claessens, YÉ., Ray, P. (eds) Les biomarqueurs en médecine d’urgence. Références en médecine d’urgence. Collection de la SFMU. Springer, Paris. https://doi.org/10.1007/978-2-8178-0297-8_23

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  • DOI: https://doi.org/10.1007/978-2-8178-0297-8_23

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0296-1

  • Online ISBN: 978-2-8178-0297-8

  • eBook Packages: MedicineMedicine (R0)

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