Résumé
L’adrénomédulline (ADM) est une hormone découverte au début des années 1990, qui connaît un regain d’intérêt dans le domaine d’application des biomarqueurs. Initialement caractérisée dans les glandes surrénales, l’ADM a été détectée dans de nombreux autres tissus et la circulation systémique. Son activité biologique dépend de sa forme mature. Les propriétés vasomotrices de l’ADM ont suggéré son intérêt potentiel comme témoin de l’équilibre hémodynamique. Récemment, les progrès techniques conduisant au dosage plus stable de la pro-hormone ont permis de mieux étudier et comprendre le rôle de l’ADM dans diverses situations cliniques aigués, et son intérêt comme marqueur de sévérité.
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Becker KL, Nylen ES, White JC et al. (2004) Procalcitonin and the calcitonin gene family of peptides in inflammation, infection and sepsis: a journey from calcitonin back to its precursors. J Clin Endocrinol Metab 89: 1512–1525
Morgenthaler NG, Struck J, Alonso C, Bergmann A (2005) Measurement of Midregional Proadrenomedullin in Plasma with an Immunoluminometric Assay. Clin Chem 51: 1823–1829
Kitamura K, Kangawa K, Kawamoto M, et al. (1993) Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 192: 553–560
Samson WK (2001) Proadrenomedullin derived peptides. Front Neuroendocrinol 19: 100–127
Yanagawa B, Nagaya N (2007) Adrenomedullin: molecular mechanisms and its role in cardiac disease. Amino Acids 32: 157–164
Matsui E, Kitamura K, Yoshida M, et al. (2001) Biosynthesis and secretion of adrenomedullin and pro-adrenomedullinN-terminal 20 peptide in a rat model of endotoxin shock. Hypertens Res 24: 543–549
Nishikimi T, Kitamura K, Saito Y, et al. (1994) Clinical studies on the sites of production and clearance of circulatingadrenomedullin in human subjects. Hypertension 24: 600–604
Vizzaa CD, Letiziab C, Sciomera S, et al. (2005) Increased plasma levels of adrenomedullin, a vasoactive peptide, in patients with end-stage pulmonary disease. Regul Peptide 124: 187–193
Samson WK (2001) Proadrenomedullin derived peptides. Front Neuroendocrinol 19: 100–127
Yanagawa B, Nagaya N (2007) Adrenomedullin: molecular mechanisms and its role in cardiac disease. Amino Acids 32: 157–164
Shimosawa T, Ito Y, Ando K, et al. (1995) Proadrenomedullin NH2-terminal 20 Peptide, a New Product of the Adrenomedullin Gene, Inhibits Norepinephrine Overflow from Nerve Endings. J Clin Invest 96: 1672–1676
Behnes M, Papassotiriou J, Walter T, et al. (2008) Long-term prognostic value of midregional pro-adrenomedullin and C-terminal pro-endothelin-l in patients with acute myocardial infarction. Clin Chem Lab Med 462: 204–211
Khan SQ, O’Brien RJ, Struck J, et al. (2007) Prognostic Value of Midregional Pro-Adrenomedullin in Patients With Acute Myocardial Infarction. J Am Coll Cardiol 49: 1525–1532
Dhillon OS, Khan SQ, Narayan HK, et al. (2010) Prognostic Value of Mid-Regional Pro-Adrenomedullin Levels Taken on Admission and Discharge in Non—ST-Elevation Myocardial Infarction. The LAMP (Leicester Acute Myocardial Infarction Peptide) II Study. J Am Coll Cardiol 56: 125–133
Stolz D, Christ-Crain M, Morgenthaler NG, et al. (2008) Plasma proadrenomedullin but not plasma pro-endothelin predicts survival in exacerbations of COPD. Chest 134: 263–272
Struck J, Tao C, Morgenthaler NG, Bergmann A (2004) Identification of an Adrenomedullin precursor fragment in plasma of sepsis patients. Peptides 25: 1369–1372
Christ-Crain M, Morgenthaler NG, Struck J, et al. (2005) Mid-regional proadrenomedullin as a prognostic marker in sepsis: an observational study. Crit Care 9:R816–824
Guignant C, Voirin N, Venet F, et al. (2009) Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients. Intensive Care Med 35: 1859–1867
Christ-Crain M, Morgenthaler NG, Stolz D, et al. (2006) Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]. Crit Care 10: R96
Huang DT, Angus DC, Kellum JA, etal. (2009) Midregionalproadrenomedullin as a prognostic tool in community-acquired pneumonia. Chest 136: 823–831
Schuetz P, Wolbers M, Christ-Crain M, et al. ProHOSP Study Group (2010) Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections. Crit Care 14: R106
Krüger S, Ewig S, Giersdorf S, et al. (2010) the German Competence Network for the Study of Community Acquired Pneumonia (CAPNETZ) Study Group. Cardiovascular and Inflammatory Biomarkers to Predict Short-and Long-Term Survival in Community-acquired Pneumonia: Results from the German Competence Network, CAPNETZ. Am J Respir Crit Care Med 182: 1426–1434
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Claessens, YÉ., Trabattoni, É. (2012). Le Mid regional proadrenomedullin (MRproADM). In: Claessens, YÉ., Ray, P. (eds) Les biomarqueurs en médecine d’urgence. Références en médecine d’urgence. Collection de la SFMU. Springer, Paris. https://doi.org/10.1007/978-2-8178-0297-8_20
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