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Exploitation de la distance sémantique pour la création de groupements de termes en pharmacovigilance

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Book cover Systèmes d’information pour l’amélioration de la qualité en santé

Part of the book series: Informatique et Santé ((INFORMATIQUE,volume 1))

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Abstract

Pharmacovigilance is the activity related to the collection, analysis and prevention of adverse drug reactions (ADRs) induced by drugs. Beside other methods, statistical methods are used to detect new ADRs in the framework of signal detection. Groupings of terms containing similar ADRs allow to increase the signal intensity and to improve the detection of new ADRs. SMQs have become reference groupings in the field of pharmacovigilance. They are built on the MedDRA terminology and thanks to the study of scientific literature. Even if SMQs are built manually by experts, they still show some shortcomings: they tend to be over-inclusive and thus become too sensitive, although they can also miss several relevant terms. Moreover, the spectrum of available SMQs is limited. The objective of this work is to propose an automated method for a flexible creation of groupings of terms. This method is based on exploitation of the semantic distance between MedDRA terms. In a first experience, we used ARD terms alone and obtained results with a high precision (mean 74% within the interval [49; 91]). In a second experience, we used ADR terms and their formal definitions and this worsened the results because the semantic information within definitions may be missing. We assume that more exhaustive definitions will have a positive effect on results.

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Authors and Affiliations

  1. SPIM, UMRS Inserm 872 équipe 20, Centre de recherche des cordeliers, 15 rue de l’École de Médecine, 75006, Paris, France

    Marie Dupuch, Anne Jamet & Marie-Christine Jaulent

  2. Centre Régional de Pharmacovigilance, HEGP, AP-HP, Paris, France

    Anne Jamet

  3. CSL Behring GmbH, Marburg, Allemagne

    Reinhard Fescharek

  4. CNRS UMR 8163 STL, Université Lille 3, Lille, France

    Natalia Grabar

Authors
  1. Marie Dupuch
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  2. Anne Jamet
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  3. Marie-Christine Jaulent
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  4. Reinhard Fescharek
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  5. Natalia Grabar
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Corresponding author

Correspondence to Marie Dupuch .

Editor information

Editors and Affiliations

  1. Département d’Information et d’Informatique Médicale, Centre Hospitalier Universitaire de Nice Hôpital de Cimiez, 4 Avenue Reine Victoria, B.P. 1179, 06003, Nice Cedex 1, France

    Pascal M. Staccini

  2. Service de Médecine Interne, C.H.U. Mongi Slim - La Marsa, 2046, Sidi-Daoud, Tunis, Tunisie

    Ali Harmel

  3. Equipe CISMeF, Cour Leschevin Porte 21, 3ème étage 1 rue de Germont, 76031, Rouen Cedex, France

    Stéfan J. Darmoni

  4. Service de Neurologie, C.H.U. Razi, 2010, La Manouba, Tunis, Tunisie

    Riadh Gouider

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© 2011 Springer-Verlag France

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Dupuch, M., Jamet, A., Jaulent, MC., Fescharek, R., Grabar, N. (2011). Exploitation de la distance sémantique pour la création de groupements de termes en pharmacovigilance. In: Staccini, P.M., Harmel, A., Darmoni, S.J., Gouider, R. (eds) Systèmes d’information pour l’amélioration de la qualité en santé. Informatique et Santé, vol 1. Springer, Paris. https://doi.org/10.1007/978-2-8178-0285-5_3

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  • DOI: https://doi.org/10.1007/978-2-8178-0285-5_3

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0284-8

  • Online ISBN: 978-2-8178-0285-5

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