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Ki-67 : niveau de preuve et considérations méthodologiques pour son utilisation dans la décision thérapeutique — revue analytique et critique

  • Conference paper
Cancer du sein : surdiagnostic, surtraitement

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Résumé

Les cliniciens souhaitent disposer de biomarqueurs sélectionnant les patientes porteuses d’un cancer du sein RE+ qui pourraient ne pas recevoir de chimiothérapie. Le degré de prolifération cellulaire est un élément essentiel dans ce choix : Ki-67 est connu depuis de nombreuses années et est facilement réalisé par les anatomopathologistes, mais il n’est pas considéré comme un standard dans la pratique quotidienne.

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Authors and Affiliations

  1. Centre d’investigation clinique de cancérologie, CHU - Centre Alexis Vautrin, Vandoeuvre-lès-Nancy

    E. Luporsi

  2. Département d’oncologie, Institut Gustave Roussy, Villejuif

    F. André & M. Spielmann

  3. Laboratoire d’oncogénétique, Institut Curie, Hôpital René Huguenin, St-Cloud

    F. Spyratos

  4. Laboratoire de transfert, Oncologie biologique, AP-HM, Marseille

    P -M. Martin

  5. Département de bio-pathologie, Institut Paoli-Calmettes, Marseille

    J. Jacquemier

  6. Département de pathologie, Centre Jean Perrin et EA 4233, Université d’Auvergne, Clermont, Ferrand

    F. Penault-Llorca

  7. Département d’oncologie médicale, CHU Dupuytren, Limoges

    N. Tubiana-Mathieu

  8. Département de pathologie, Institut Curie, Paris

    B. Sigal-Zafrani

  9. Département de biologie tumorale et de pathologie, centre Georges-François Leclerc, Dijon

    L. Arnould

  10. Unité de gynécologie, Université Paris Descartes, Inserm UMRS 938, Hôtel-Dieu, AP-HP, Paris

    A. Gompel

  11. Département de pathologie, Hôpital universitaire, Strasbourg

    C. Egele, M -P. Chenard & J -P. Bellocq

  12. laboratoire privé de pathologie, Paris

    B. Poulet

  13. Département de chirurgie, l’Institut du sein/Paris Centre Sein, Paris

    K. B. Clough

  14. Département de Chirurgie Oncologique, Centre François Baclesse, Caen

    H. Crouet

  15. Département d’oncologie radiothérapie, Institut Curie, Paris

    A. Fourquet

  16. Département de chirurgie gynécologique et du cancer du sein, Pitié-Salpêtrière, AP-HP, Paris

    J -P. Lefranc

  17. Département de gynécologie & obstétrique, Hôpital Universitaire, Strasbourg

    C. Mathelin

  18. Laboratoire de pathologie SELARL DIAG, Nice

    N. Rouyer

  19. Département d’oncologie médicale, Institut Sainte-Catherine, Avignon, France

    D. Serin

  20. Consultant Indépendant, MediCom Consult, Villeurbanne

    M. Haugh

  21. Département d’oncologie médicale, Institut Curie - Hôpital René Huguenin, St-Cloud

    E. Brain

  22. Département de biologie tumorale, hôpital Saint-Louis, AP-HP, Paris

    P. de Cremoux

Authors
  1. E. Luporsi
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  2. F. André
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  3. F. Spyratos
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  4. P -M. Martin
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  5. J. Jacquemier
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  6. F. Penault-Llorca
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  7. N. Tubiana-Mathieu
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  8. B. Sigal-Zafrani
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  9. L. Arnould
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  10. A. Gompel
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  11. C. Egele
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  12. B. Poulet
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  13. K. B. Clough
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  14. H. Crouet
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  15. A. Fourquet
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  16. J -P. Lefranc
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  17. C. Mathelin
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  18. N. Rouyer
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  19. D. Serin
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  20. M. Spielmann
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  21. M. Haugh
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  22. M -P. Chenard
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  23. E. Brain
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  24. P. de Cremoux
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  25. J -P. Bellocq
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© 2012 Springer-Verlag France, Paris

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Luporsi, E. et al. (2012). Ki-67 : niveau de preuve et considérations méthodologiques pour son utilisation dans la décision thérapeutique — revue analytique et critique. In: Cancer du sein : surdiagnostic, surtraitement. Springer, Paris. https://doi.org/10.1007/978-2-8178-0249-7_48

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  • DOI: https://doi.org/10.1007/978-2-8178-0249-7_48

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0248-0

  • Online ISBN: 978-2-8178-0249-7

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