Skip to main content

Micrométastases du (des) ganglion sentinelle: Indications du curage axillaire et des traitements adjuvants

  • Conference paper
Cancer du sein
  • 556 Accesses

Résumé

Le taux de ganglion non sentinelle (GNS) envahi en cas de macrométastase (> 2 mm) du ou des ganglions sentinelles (GS) est important, globalement de 50 %. Le curage axillaire est donc indiqué en pratique clinique dans cette situation et reste un standard.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. Van Zee KJ, Manasseh DM, Bevilacqua JL et al. (2003) A nomogram for predicting the likelihood of additional nodal metastases in breast cancer patients with a positive sentinel node biopsy. Ann Surg Oncol 10: 1140–1151

    Article  PubMed  Google Scholar 

  2. Kocsis L, Svebis M, Boross G et al. (2004) Use and limitations of a nomogram predicting the likelihood of non-sentinel node involvement after a positive sentinel node biopsy in breast cancer patients. Am Surg 70: 1019–1024

    PubMed  Google Scholar 

  3. Soni NK, Carmalt HL, Gillett DJ et al. (2005) Evaluation of a breast cancer nomogram for prediction of non-sentinel lymph node positivity. Eur J Surg Oncol 31: 958–964

    Article  PubMed  CAS  Google Scholar 

  4. Smidt ML, Kuster DM, van der Wilt GJ et al. (2005) Can the Memorial Sloan-Kettering Cancer Center nomogram predict the likelihood of nonsentinel lymph node metastases in breast cancer patients in the Netherlands? Ann Surg Oncol 12: 1066–1072

    Article  PubMed  Google Scholar 

  5. Degnim AC, Reynolds C, Pantvaidya G et al. (2005) Nonsentinel node metastasis in breast cancer patients: assessment of an existing and a new predictive nomogram. Am J Surg 190: 543–550

    Article  PubMed  Google Scholar 

  6. Specht MC, Kattan MW, Gonen M et al. (2005) Predicting nonsentinel node status after positive sentinel lymph biopsy for breast cancer: clinicians versus nomogram. Ann Surg Oncol 12: 654–659

    Article  PubMed  Google Scholar 

  7. Lambert LA, Ayers GD, Hwang RF et al. (2006) Validation of a breast cancer nomogram for predicting nonsentinel lymph node metastases after a positive sentinel node biopsy. Ann Surg Oncol 13: 310–320

    Article  PubMed  Google Scholar 

  8. Cripe MH, Beran LC, Liang WC et al. (2006) The likelihood of additional nodal disease following a positive sentinel lymph node biopsy in breast cancer patients: validation of a nomogram. Am J Surg 192: 484–487

    Article  PubMed  Google Scholar 

  9. Coutant C (2006) A predictive score for additional lymph node involvement in the presence of sentinel node positivity in brest cancer: description and prospective evaluation. In hptts://www.medecine.univ-paris5.fr/IMG/pdf/Coutant.pdf, Edition University Rene Descartes, Paris V, p 128

    Google Scholar 

  10. Dauphine CE, Haukoos JS, Vargas MP et al. (2007) Evaluation of three scoring systems predicting non sentinel node metastasis in breast cancer patients with a positive sentinel node biopsy. Ann Surg Oncol 14: 1014–1019

    Article  PubMed  Google Scholar 

  11. Zgajnar J, Perhavec A, Hocevar M et al. (2007) Low performance of the MSKCC nomogram in preoperatively ultrasonically negative axillary lymph node in breast cancer patients. J Surg Oncol 96: 547–553

    Article  PubMed  Google Scholar 

  12. Ponzone R, Maggiorotto F, Mariani L et al. (2007) Comparison of two models for the prediction of nonsentinel node metastases in breast cancer. Am J Surg 193: 686–692

    Article  PubMed  Google Scholar 

  13. Bevilacqua JL, Kattan MW, Fey JV et al. (2007) Doctor, what are my chances of having a positive sentinel node? A validated nomogram for risk estimation. J Clin Oncol 25: 3670–3679

    Article  PubMed  Google Scholar 

  14. Pal A, Provenzano E, Duffy SW et al. (2008) A model for predicting non-sentinel lymph node metastatic disease when the sentinel lymph node is positive. Br J Surg 95: 302–309

    Article  PubMed  CAS  Google Scholar 

  15. Alran S, De Rycke Y, Fourchotte V et al. (2007) Validation and limitations of use of a breast cancer nomogram predicting the likelihood of non-sentinel node involvement after positive sentinel node biopsy. Ann Surg Oncol 14: 2195–2201

    Article  PubMed  Google Scholar 

  16. Coutant C, Rouzier R, Fondrinier E et al. (2009) Validation of the Tenon breast cancer score for predicting non-sentinel lymph node status in breast cancer patients with sentinel lymph node metastasis: a prospective multicenter study. Breast Cancer Res Treat 113: 537–543

    Article  PubMed  Google Scholar 

  17. Kohrt HE, Olshen RA, Bermas HR et al. (2008) New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients. BMC Cancer 8: 66

    Article  PubMed  Google Scholar 

  18. Klar M, Jochmann A, Foeldi M, Stumpf M, Gitsch G, Stickeler E, Watermann D (2008) The MSKCC nomogram for prediction the likelihood of non-sentinel node involvement in a German breast cancer population. Breast Cancer Res Treat 112: 523–531

    Article  PubMed  CAS  Google Scholar 

  19. Coutant C, Olivier C, Lambaudie E et al. (2009) Comparison of models to predict non-sentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes: a prospective muti-center study. J Clin Oncol 27: 2800–2808

    Article  PubMed  Google Scholar 

  20. Werkoff G, Lambaudie E, Fondrinier E et al. (2009) Prospective multicenter comparison of models to predicts four or more involved axillary lymph nodes in patients with breast cancer with one to three metastatic sentinel lymph nodes. J Clin Oncol 27: 5707–5712

    Article  PubMed  Google Scholar 

  21. Houvenaeghel G, Nos C, Giard S et al. (2009) A nomogram predictive of non sentinel lymph node involvement in breast cancer patients with a sentinel lymph node micrometastasis. Eur J Surg Oncol 35: 690–695

    Article  PubMed  CAS  Google Scholar 

  22. Coutant C, Olivier C, Lambaudie E et al. (2009) Comparison of models to predict nonsentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes: a prospective multicenter study. J Clin Oncol 27: 2800–2808

    Article  PubMed  Google Scholar 

  23. Houvenaeghel G, Cohen M, Bannier M, Lambaudie E, Buttarelli M (2010) Micrométastases du (des) ganglion sentinelle: valeur pronostique et conduite thérapeutique. Bull Cancer (soumis)

    Google Scholar 

  24. Houvenaeghel G, Nos C, Giard S et al. (2006) Micrometastases in sentinel lymph node in a multicentric study: predictive factors of nonsentinel lymph node involvement — Groupe des Chirurgiens de la Fédération des Centres de Lutte Contre le Cancer. J Clin Oncol 24: 1814–1822

    Article  PubMed  Google Scholar 

  25. Cserni G, Gregori D, Merletti F et al. (2004) Meta-anamysis of non-sentinel node metastases associated with micrometastatic sentinel nodes in breast cancer. Br J Surg 91: 1245–1252

    Article  PubMed  CAS  Google Scholar 

  26. Viale G, Maiorano E, Pruneri G et al. (2005) Predicting the risk for additional axillary metastases in patients with breast carcinoma and positive sentinel lymph node biopsy. Ann Surg 241: 319–325

    Article  PubMed  Google Scholar 

  27. Cserni G, Bianchi S, Vezzosi V et al. (2008) Variations in sentinel node isolated tumour cells/micrometastasis and non-sentinel node involvement rates according to different interpretations of the TNM definitions. Eur J Cancer 44: 2185–2191

    Article  PubMed  Google Scholar 

  28. Chu KU, Turner RR, Hansen NM et al. (1999) Sentinel node metastasis in patients with breast carcinoma accurately predicts immunohistochemically detectable nonsentinel node metastasis. Ann Surg Oncol 6: 756–761

    Article  PubMed  CAS  Google Scholar 

  29. Canavese G, Gipponi M, Catturich A et al. (2001) Technical issues and pathologic implications of sentinel lymph node biopsy in early-stage breast cancer patients. J Surg Oncol 77: 81–87

    Article  PubMed  CAS  Google Scholar 

  30. Marin C, Mathelin C, Neuville A et al. (2003) Sentinel lymph node biopsy with micrometastases in breast cancer: histological data and surgical implications. Bull Cancer 90: 459–465

    PubMed  Google Scholar 

  31. Dabbs DJ, Fung M, Landsittel D et al. (2004) Sentinel lymph node micrometastasis as a predictor of axillary tumor burden. The Breast Journal 10: 101–105

    Article  PubMed  Google Scholar 

  32. Czerniecki BJ, Scheff AM, Callans LS et al. (1999) Immunohistochemistry with pancytokeratins improves the sensitivity of sentinel lymph node biopsy in patients with breast carcinoma. Cancer 85: 1098–1103

    Article  PubMed  CAS  Google Scholar 

  33. Reynolds C, Mick R, Donohue JH et al. (1999) Sentinel lymph node biopsy with metastasis: can axillary dissection be avoided in some patients with breast cancer? J Clin Oncol 17: 1720–1726

    PubMed  CAS  Google Scholar 

  34. Turner RR, Chu KU, Qi K et al. (2000) Pathologic features associated with nonsentinel lymph node metastases in patients with metastatic breast carcinoma in a sentinel lymph node. Cancer 89: 574–558

    Article  PubMed  CAS  Google Scholar 

  35. Changsri C, Prakash S, Sandweiss L et al. (2004) Prediction of additional axillary metastasis of breast cancer following sentinel lymph node surgery. The Breast Journal 10: 392–397

    Article  PubMed  Google Scholar 

  36. Teng S, Dupont E, McCann C et al. (1999) Sentinel lymph node biopsy with metastasis: can axillary dissection be avoided in some patients with breast cancer? J Clin Oncol 17: 1720–1726

    Google Scholar 

  37. Kamath VJ, Giuliano R, Dauway EL et al. (2001) Characteristics of the sentinel lymph node in breast cancer predict further involvement of higher-echelon nodes in the axilla. Arch Surg 136: 688–692

    Article  PubMed  CAS  Google Scholar 

  38. Wong SL, Edwards MJ, Chao C et al. (2001) Predicting the status of the nonsentinel axillary nodes: a multicenter study. Arch Surg 136: 563–568

    Article  PubMed  CAS  Google Scholar 

  39. Jakub JW, Diaz NM, Ebert MD (2002) Completion axillary lymph node dissection minimizes the likelihood of false negatives for patients with invasive breast carcinoma and cytokeratin positive only sentinel nodes. Am J Surg 184: 302–306

    Article  PubMed  Google Scholar 

  40. Fleming FJ, Kavanagh D, Crotty TB et al. (2004) Factors affecting metastases to nonsentinel lymph nodes in breast cancer. J Clin Pathol 57: 73–76

    Article  PubMed  CAS  Google Scholar 

  41. Fréneaux P, Nos C, Vincent-Salomon A, Genin P (2002) Histological detection of minimal metastatic involvement in axillary sentinel nodes: a rational basis for a sensitive methodology usable in daily practice. Mod Pathol 20: 641–646

    Article  Google Scholar 

  42. Abdessalam SF, Zervos EE, Prasad M et al. (2001) Predictors of positive axillary lymph nodes after sentinel lymph node biopsy in breast cancer. Am J Surg 182: 316–320

    Article  PubMed  CAS  Google Scholar 

  43. Bergkvist L, Frisell J, Liljegren G et al. (2001) Multicentre study of detection and false-negative rates in sentinel node biopsy for breast cancer. Br J Surg 88: 1644–1648

    Article  PubMed  CAS  Google Scholar 

  44. Saidi RF, Dudrick PS, Remine SG et al. (2004) Nonsentinel lymph node status after positive sentinel lymph node biopsy in early breast cancer. Am Surg 70: 101–105

    PubMed  Google Scholar 

  45. Mignotte H, Treilleux I, Faure C et al. (2002) Axillary lymph-node dissection for positive sentinel nodes in breast cancer patients. Eur J Surg Oncol 28: 623–626

    Article  PubMed  CAS  Google Scholar 

  46. Nos C, Harding-Mackean C, Fréneaux P et al. (2003) Predicting positivy of nonsentinel axillary nodes in breast cancer patients with sentinel node metastases. Br J Surg 90: 1354–1360

    Article  PubMed  CAS  Google Scholar 

  47. Hwang RF, Krishnamurthy S, Hunt KK et al. (2003) Clinicopathologic factors predicting involvement of nonsentinel axillary nodes in women with breast cancer. Ann Surg Oncol 10: 248–254

    Article  PubMed  Google Scholar 

  48. Mc Cready D, Yong WS, Ng AKT et al. (2004) Influence of the new AJCC breast cancer staging system on sentinel lymph node positivity and false-negative rates. Am J Surg 182: 316–320

    Google Scholar 

  49. Rahussen FD, Pijpers R, Van Diest PJ et al. (2000) The implementation of the sentinel node biopsy as a routine procedure for patients with breast cancer. Surg 91: 1245–1252

    Google Scholar 

  50. Sachdev U, Murphy K, Derzic A et al. (2002) Predictors of non sentinel lymph node metastasis in breast cancer patients. Am J Surg 183: 213–217

    Article  PubMed  Google Scholar 

  51. Joseph KA, El-Tamer M, Komenaka I (2004) Predictors of sentinel node metastasis in patients with breast cancer after sentinel node metastasis. Arch Surg 139: 648–651

    Article  PubMed  Google Scholar 

  52. Chua B, Ung O, Taylor R (2001) Treatment implications of a positive sentinel lymph node biopsy for patients with biopsy for patients with early-stage breast carcinoma. Cancer 92: 1769–1774

    Article  PubMed  CAS  Google Scholar 

  53. Cserni G (2007) Comparison of different validation studies on the use of the Memorial-Sloan Kettering Cancer Center nomogram predicting nonsentinel node involvement in sentinel node-positive breast cancer patients. Am J Surg 194: 699–700

    Article  PubMed  Google Scholar 

  54. Bolster MJ, Peer PGM, Bult P et al. (2006) Risk factors for non-sentinel lymph node metastases in patients with breast cancer. The outcome of a multi-institutional study. Ann Surg Oncol 14: 181–189

    Article  PubMed  Google Scholar 

  55. Van Rijk MC, Peterse JL, Nieweg OE, Oldenburg HS, Rutgers EJ, Kroon BB (2006) Additional axillary metastases and stage migration in breast cancer patients with micrometastases or submicrometastases in sentinel lymph nodes. Cancer 107: 467–471

    Article  PubMed  Google Scholar 

  56. Rydén L, Chebil G, Sjöström L, Pawlowski R, Jönsson PE (2007) Determination of sentinel lymph node (SLN) status in primary breast cancer by prospective use of immunohistochemistry increases the rate of micrometastases and isolated tumour cells: Analysis of 174 patients after SLN biopsy. Eur J Surg 33: 33–38

    Google Scholar 

  57. Menes TS, Tartter PI, Mizrachi H, Constantino J, Estabrook A, Smith SR (2005) Breast cancer patients xith pN0(i+) and pN1(mi) sentinel nodes have high rate of nonsentinel node metastases. J Am Coll Surg 200: 323–327

    Article  PubMed  Google Scholar 

  58. Krauth JS, Charitansky H, Issac S, Bobin JY (2006) Clinical implications of axillary sentinel lymph node »micrometastases« in breast cancer. Eur J Surg Oncol 32: 400–404

    Article  PubMed  Google Scholar 

  59. Klevesath MB, Bobrow LG, Pinder SE, Purushotham AD (2005) The value of immunohistochemistry in sentinel lymph node histopathology in breast cancer. Br J Cancer 92: 2201–2205

    Article  PubMed  CAS  Google Scholar 

  60. Schrenk P, Konstantiniuk P, Wölfl S et al. (2005) Prediction of non-sentinel lymph node status in breast cancer with a micrometastatic sentinel node. Br J Surg 92: 707–713

    Article  PubMed  CAS  Google Scholar 

  61. Langer I, Guller U, Berclaz G et al.; For the Swiss Multicenter Study Group Sentinel Lymph Node in Breast Cancer (2009) Accuracy of frozen section of sentinel lymph nodes: a prospective analysis of 659 breast cancer patients of the Swiss multicenter study. Breast Cancer Res Treat 113: 129–136

    Article  PubMed  Google Scholar 

  62. Van Deurzen CH, Seldenrijk CA, Koelemij R et al. (2008) The microanatomic location of metastatic breast cancer in sentinel lymph nodes predicts nonsentinel lymph node involvement. Ann Surg Oncol 15: 1309–1315

    Article  PubMed  Google Scholar 

  63. Fink AM, Lass H, Hartleb H, Jurecka W, Salzer H, Steiner A (2008) S-classification of sentinel lymph node predicts axillary nonsentinel lymph node status in patients with breast cancer. Ann Surg Oncol 15: 848–853

    Article  PubMed  Google Scholar 

  64. Cox Ce, Kiluk JV, River Al et al. (2008) Significance of sentinel lymph node micromestastases in human bresat cancer. J Am Coll Surg 206: 261–268

    Article  PubMed  Google Scholar 

  65. Rivers AK, Griffith KA, Hunt KK et al. (2006) Clinicopathologic features associated with having four or more metastatic axillary nodes in breast cancer patients with a positive sentinel lymph node. Ann Surg Oncol 13: 36–44

    Article  PubMed  Google Scholar 

  66. Houvenaeghel G, Nos C, Giard S et al. Non sentinel node involvement prediction for sentinel node micrometastases in breast cancer: nomogram validation and comparison with other models. BREAST (in press)

    Google Scholar 

  67. Giuliano AE, McCall L, Beitsch P et al. (2010) Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial. Ann Surg 252: 426–432

    PubMed  Google Scholar 

  68. Bilimoria KY, Bentrem DJ, Hansen NM et al. (2009) Comparison of sentinel lymph node biopsy alone complexion axillary lymph node dissection for node positive breast cancer. J Clin Oncol 27: 2946–2953

    Article  PubMed  Google Scholar 

  69. Houvenaeghel G, Martino M, Jacquemier J et al. (2003) Risk of stage underestimation of breast cancer by sentinel lymph node biopsy method. Bull Cancer 90: 467–473

    PubMed  Google Scholar 

  70. Straver ME, Meijnen P, van Tienhoven G et al. (2010) Role of axillary clearance after a tumor-positive sentinel node in the administration of adjuvant therapy in early breast cancer. J Clin Oncol 28: 731–737

    Article  PubMed  Google Scholar 

  71. Fisher ER, Swamidoss S, Lee CH, Rockette H, Redmond C, Fisher B (1983) Detection and significance of occult axillary node metastases in patients with invasive breast cancer. Cancer 42: 1551–1557

    Article  Google Scholar 

  72. Huvos AG HR, Berg JW (1971) Significance of axillary macrometastases and micrometastases in mammary cancer. Ann Surg 173: 44–46

    Article  PubMed  CAS  Google Scholar 

  73. Pickren JW (1961) Significance of occult metastases. Astudy of breast cancer. Cancer 14: 1266–1271

    Article  PubMed  CAS  Google Scholar 

  74. Maibenco DC, Dombi GW, Kau TY, Severson RK (2006) Significance of micrometastases on the survival of women with T1 breast cancer. Cancer 107: 1234–1239

    Article  PubMed  Google Scholar 

  75. Cote RJ, Peterson HF, Chaiwun B et al. (1999) Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. International Breast Cancer Study Group. Lancet 354: 896–900

    CAS  Google Scholar 

  76. Trojani M, de Mascarel I, Bonichon F, Coindre JM, Delsol G (1987) Micrometastases to axillary lymph nodes from carcinoma of breast: detection by immunohistochemistry and prognostic significance. Br J Cancer 55: 303–306

    Article  PubMed  CAS  Google Scholar 

  77. Friedman S, Bertin F, Mouriesse H et al. (1988) Importance of tumor cells in axillary node sinus margins (‘clandestine’ metastases) discovered by serial sectioning in operable breast carcinoma. Acta Oncol 27: 483–487

    Article  PubMed  CAS  Google Scholar 

  78. Hainsworth PJ, Tjandra JJ, Stillwell RG et al. (1993) Detection and significance of occult metastases in node-negative breast cancer. Br J Surg 80: 459–463

    Article  PubMed  CAS  Google Scholar 

  79. McGuckin MA, Cummings MC, Walsh MD, Hohn BG, Bennett IC, Wright RG (1996) Occult axillary node metastases in breast cancer: their detection and prognostic significance. Br J Cancer 73: 88–95

    Article  PubMed  CAS  Google Scholar 

  80. Nasser IA, Lee AK, Bosari S, Saganich R, Heatley G, Silverman ML (1993) Occult axillary lymph node metastases in »node-negative« breast carcinoma. Hum Pathol 24: 950–957

    Article  PubMed  CAS  Google Scholar 

  81. Wilkinson EJ, Hause LL, Hoffman RG et al. (1982) Occult axillary lymph node metastases in vasive breast carcinoma: characteristics of the primary tumor and significance of the metastases. Pathol Ann 17Pt2: 67–91

    Google Scholar 

  82. Querzoli P, Pedriali M, Rinaldi R et al. (2006) Axillary lymph node nanometastases are prognostic factors for disease-free survival and metastatic relapse in breast cancer patients. Clin Cancer Res 12: 6696–6701

    Article  PubMed  CAS  Google Scholar 

  83. Hansen NM, Grube BJ, Te W et al. (2001) Clinical significance of axillary micrometastases in breast cancer: how small is to small? Proc Am Soc Clin Oncol 20: 91a

    Google Scholar 

  84. Hansen NM, Grube B, Ye X et al. (2009) Impact of micrometastases in the sentinel node of patients with invasive breast cancer. J Clin Oncol 27: 4679–4684

    Article  PubMed  Google Scholar 

  85. Cox C, Vrcel V, Riker A et al. (2005) Significance of sentinel lymph node micrometastasis on survival for patients with invasive breast cancer. Breast Cancer Res Treat 94: S12–S13

    Google Scholar 

  86. Chagpar A, Middleton LP, Sahin AA et al. (2005) Clinical outcome of patients with lymph node-negative breast carcinoma who have sentinel lymph node micrometastases detected by immunohistochemistry. Cancer 103: 1581–1586

    Article  PubMed  Google Scholar 

  87. Mittendorf EA, Hunt KK (2007) Significance and management of micrometastases in patients with breast cancer. Expert Rev Anticancer Ther 10: 1451–1461

    Article  Google Scholar 

  88. Colleoni M, Rotmensz N, Peruzzotti G et al. (2005) Size of breast cancer metastases in axillary lymph nodes: clinical relevance of minimal lymph node involvement. J Clin Oncol 23: 1379–1389

    Article  PubMed  Google Scholar 

  89. Cox CE, Kiluk JV, Riker AI et al. (2008) Significance of sentinel lymph node micrometastases in human breast cancer. J Am Coll Surg 206: 261–268

    Article  PubMed  Google Scholar 

  90. Gobardhan PD, Elias SG, Madsen EV et al. (2009) Prognostic value of micrometastases in sentinel lymph nodes of patients with breast carcinome: a cohort study. Ann Oncol 20: 41–48

    Article  PubMed  CAS  Google Scholar 

  91. Kuijt GP, Voogd AC, van de Poll-Franse LV et al. (2005) The prognostic significance of axillary lymph-node micrometastases in breast cancer patients. Eur J Surg Oncol 31: 500–505

    Article  PubMed  CAS  Google Scholar 

  92. Grabau D, Jensen MB, Rank F, Blichert-Toft M (2007) Axillary lymph node micrometastases in invasive breast cancer: national figures on incidence and overall survival. APMIS 115: 828–837

    Article  PubMed  CAS  Google Scholar 

  93. Chen SL, Hoehne FM, Giuliano AE (2007) The prognostic significance of micrometastases in breast cancer: a SEER population-based analysis. Ann Surg Oncol 14: 3378–3384

    Article  PubMed  Google Scholar 

  94. de Boer M, van Dijck JA, Bult P, Borm GF, Tjan-Heijnen VC (2010) Breast cancer prognosis and occult lymph node metastases, isolated tumor cells, and micrometastases. J Natl Cancer Inst 102: 410–425

    Article  PubMed  Google Scholar 

  95. de Boer M, Van Deurzen CH, Van Dijck et al. (2009) Micrometastases or isolated tumor cells and the outcome of breast cancer. N Engl J Med 361: 653–663

    Article  PubMed  Google Scholar 

  96. Reed J, Rosman M, Verbanac KM, Mannie A, Chend Z, Tafra L (2009) Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study. J Am Coll Surg 208: 333–340

    Article  PubMed  Google Scholar 

  97. Maaskant-Braat AJ, van de Poll-Franse LV, Voogd AC et al. (2010) Sentinel node micrometastases in breast cancer do not affect prognosis: a population-based study. Breast Cancer Res Treat 127: 195–203

    Article  PubMed  Google Scholar 

  98. Katz AL, Smith B, Golshan M, Niemierko A, Kobayashi W, Abi Raad R (2008) Nomogram for the prediction of having four or more involved nodes for sentinel lymph node-positive breast cancer. J Clin Oncol 26: 2093–2098

    Article  PubMed  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag France, Paris

About this paper

Cite this paper

Houvenaeghel, G., Cohen, M., Bannier, M., Lambaudie, E., Buttarelli, M. (2012). Micrométastases du (des) ganglion sentinelle: Indications du curage axillaire et des traitements adjuvants. In: Cancer du sein. Springer, Paris. https://doi.org/10.1007/978-2-8178-0245-9_5

Download citation

  • DOI: https://doi.org/10.1007/978-2-8178-0245-9_5

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0244-2

  • Online ISBN: 978-2-8178-0245-9

Publish with us

Policies and ethics