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Les cellules Stromales: un futur thérapeutique des maladies ostéo-articulaires

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Book cover Biothèrapies en rhumatologie

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Résumé

Les cellules Stromales mésenchymateuses (MSC) ont un potentiel thérapeutique dans le domaine de la rhumatologie, avant tout sur la base de leur potentiel de différenciation en cartilage ou en tissu osseux, aujourd’hui en partie éclipsé par leur capacité à prévenir la fibrose et l’inflammation articulaire (1). Les MSC semblent être les meilleurs candidats pour la thérapie cellulaire afin de régénérer les tissus lésés, car ils sont facilement isolés à partir de la moelle osseuse (BM) ou le tissu adipeux et peuvent être rapidement amplifiés pour un usage thérapeutique (2, 3). Certaines questions restent toutefois en suspens, dont l’origine des MSC et la similitude entre les synoviocytes et les MSC. En outre, les interactions entre MSC et cellules immunitaires présentent un intérêt potentiel dans le cadre d’applications cliniques pour les maladies inflammatoires.

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Authors
  1. C. Jorgensen
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© 2011 Springer-Verlag France, Paris

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Jorgensen, C. (2011). Les cellules Stromales: un futur thérapeutique des maladies ostéo-articulaires. In: Biothèrapies en rhumatologie. Springer, Paris. https://doi.org/10.1007/978-2-8178-0124-7_13

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  • DOI: https://doi.org/10.1007/978-2-8178-0124-7_13

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0123-0

  • Online ISBN: 978-2-8178-0124-7

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