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Interférences avec l’axe corticotrope

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Sepsis grave et choc septique

Part of the book series: Le point sur … ((POINT))

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Résumé

Les glandes surrénales comportent deux entités fonctionnelles: la médullaire et le cortex. La médullaire est à l’origine de la production des hormones du système sympathique (adrénaline et noradrénaline). Le cortex surrénalien est constitué de trois zones sécrétant des hormones stéroïdes différentes. La zone glomérulée, située en superficie, synthétise les minéralocorticoïdes (aldostérone et accessoirement corticostérone), alors que la réticulée, située en profondeur, produit les androgènes faibles (déhydroépiandrostérone [DHEA], sulfate de DHEA, delta-4-androstenedione et 11-B-hydroxyandrostenedione). Enfin, la zone fasciculée du cortex surrénal synthétise les glucocorticoïdes: cortisol et cortisone.

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Réfénces

  1. Orth DN, Kovacs WJ, DeBold CR (1992) The Adrenal Cortex. In: Wilson JD, Foster DW (ed) Williams Textbook of Endocrinology, W. B. Saunders Company, Philadelphia. p 489–531

    Google Scholar 

  2. Almawi WY (2001) Molecular Mechanisms of Glucocorticoid Effects. Mod Asp Immunobiol 2(2): 78–82

    Google Scholar 

  3. Chrousos GP (1995) The hypothalamic-pituitary-adrenal axis and immune-mediated infl ammation. N Engl J Med 332(20): 1351–62

    Article  PubMed  CAS  Google Scholar 

  4. Cavaillon JM (2000) Rôle des glucocorticoïdes dans la cascade inflammatoire. Réanim Urgences 9: 605–12

    Article  Google Scholar 

  5. Tsigos C, Chrousos GP (2002) Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res 53(4): 865–71

    Article  PubMed  Google Scholar 

  6. Marik PE, Zaloga GP (2002) Adrenal insufficiency in the critically ill: a new look at an old problem. Chest 122(5): 1784–96

    Article  PubMed  Google Scholar 

  7. Pilkis SJ, Granner DK (1992) Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol 54: 885–909

    Article  PubMed  CAS  Google Scholar 

  8. Chrousos GP (2000) The Stress Response and Immune Function: Clinical Implications. The 1999 Novera H. Spector Lecture. In: Conti A, Maestroni JM, McCann SM, Sternberg EM, Lipton JM, Smith CC (ed) Neuroimmunomodulation. Perspectives at the New Millennium, Ann N Y Acad Sci, New York. p 38–67

    Google Scholar 

  9. Beishuizen A, Th ijs LG, Haanen C, Vermes I (2001) Macrophage migration inhibitory factor and hypothalamo-pituitary-adrenal function during critical illness. J Clin Endocrinol Metab 86(6): 2811–6

    Article  PubMed  CAS  Google Scholar 

  10. Beishuizen A, Vermes I, Hylkema BS, Haanen C (1999) Relative eosinophilia and functional adrenal insufficiency in critically ill patients. Lancet 353(9165): 1675–6

    Article  PubMed  CAS  Google Scholar 

  11. Keh D, Boehnke T, Weber-Cartens S et al. (2003) Immunologic and hemodynamic Effects of “low-dose” hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 167(4): 512–20

    Article  PubMed  Google Scholar 

  12. Beishuizen A, Th ijs LG (2003) Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis. J Endotoxin Res 9(1): 3–24

    PubMed  CAS  Google Scholar 

  13. Soni A, Pepper GM, Wyrwinski PM et al. (1995) Adrenal insufficiency occurring during septic shock: incidence, outcome, and relationship to peripheral cytokine levels. Am J Med 98(3): 266–71

    Article  PubMed  CAS  Google Scholar 

  14. Franchimont D, Martens H, Hagelstein MT et al. (1999) Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J Clin Endocrinol Metab 84(8): 2834–9

    Article  PubMed  CAS  Google Scholar 

  15. Muller B, Peri G, Doni A et al. (2002) High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration. J Leukoc Biol 72(4): 643–9

    PubMed  CAS  Google Scholar 

  16. Briegel J, Kellermann W, Forst H et al. (1994) Low-dose hydrocortisone infusion attenuates the systemic Inflammatory response syndrome. The Phospholipase A2 Study Group. Clin Investig 72(10): 782–7

    Article  PubMed  CAS  Google Scholar 

  17. Annane D, Bellissant E (2002) Impact des corticoïdes sur la réponse vasomotrice aux catécholamines dans le choc septique. Réanimation 11: 111–6

    Article  Google Scholar 

  18. Lamberts SW, Bruining HA, de Jong FH (1997) Corticosteroid therapy in severe illness. N Engl J Med 337(18): 1285–92

    Article  PubMed  CAS  Google Scholar 

  19. Beishuizen A, Th ijs LG, Vermes I (2001) Patterns of corticosteroid-binding globulin and the free cortisol index during septic shock and multitrauma. Intensive Care Med 27(10): 1584–91

    Article  PubMed  CAS  Google Scholar 

  20. Schroeder S, Wichers M, Klingmuller D et al. (2001) The hypothalamic-pituitary-adrenal axis of patients with severe sepsis: altered response to corticotropin-releasing hormone. Crit Care Med 29(2): 310–6

    Article  PubMed  CAS  Google Scholar 

  21. Mastorakos G, Chrousos GP, Weber JS (1993) Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J Clin Endocrinol Metab 77(6): 1690–4

    Article  PubMed  CAS  Google Scholar 

  22. Streeten DH (1999) What test for hypothalamic-pituitary-adrenocortical insufficiency? Lancet 354(9174): 179–80

    Article  PubMed  CAS  Google Scholar 

  23. Jurney TH, Cockrell JL Jr, Lindberg JS et al. (1987) Spectrum of serum cortisol response to ACTH in ICU patients. Correlation with degree of illness and mortality. Chest 92(2): 292–5

    Article  PubMed  CAS  Google Scholar 

  24. Loisa P, Rinne T, Kaukinen S (2002) Adrenocortical function and multiple organ failure in severe sepsis. Acta Anaesthesiol Scand 46(2): 145–51

    Article  PubMed  CAS  Google Scholar 

  25. Span LF, Hermus AR, Bartelink AK et al. (1992) Adrenocortical function: an indicator of severity of disease and survival in chronic critically ill patients. Intensive Care Med 18(2): 93–6

    Article  PubMed  CAS  Google Scholar 

  26. Schein RM, Sprung CL, Marcial E et al. (1990) Plasma cortisol levels in patients with septic shock. Crit Care Med 18(3): 259–63

    Article  PubMed  CAS  Google Scholar 

  27. Rothwell PM, Lawler PG (1995) Prediction of outcome in intensive care patients using endocrine parameters. Crit Care Med 23(1): 78–83

    Article  PubMed  CAS  Google Scholar 

  28. Chernow B, Alexander HR, Smallridge RC et al. (1987) Hormonal responses to graded surgical stress. Arch Intern Med 147(7): 1273–8

    Article  PubMed  CAS  Google Scholar 

  29. Rothwell PM, Udwadia ZF, Lawler PG (1991) Cortisol response to corticotropin and survival in septic shock. Lancet 337(8741): 582–3

    Article  PubMed  CAS  Google Scholar 

  30. Annane D, Sebille V, Troche G et al. (2000) A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. Jama 283(8): 1038–45

    Article  PubMed  CAS  Google Scholar 

  31. The Veterans Administration Systemic Sepsis Cooperative Study Group (1987) Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med 317(11): 659–65

    Article  Google Scholar 

  32. Bone RC, Fisher CJ Jr, Clemmer TP et al. (1987) A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 317(11): 653–8

    Article  PubMed  CAS  Google Scholar 

  33. Cronin L, Cook DJ, Carlet J et al. (1995) Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Crit Care Med 23(8): 1430–9

    Article  PubMed  CAS  Google Scholar 

  34. Annane D, Raphael JC, Gajdos P (1996) Are endogenous glucocorticoid levels adequate in septic shock? Intensive Care Med 22(7): 711–235

    Article  PubMed  CAS  Google Scholar 

  35. Marik PE, Zaloga GP (2003) Adrenal insufficiency during septic shock. Crit Care Med 31(1): 141–5

    Article  PubMed  CAS  Google Scholar 

  36. Moran JL, Chapman MJ, O’Fathartaigh MS et al. (1994) Hypocortisolaemia and adrenocortical responsiveness at onset of septic shock. Intensive Care Med 20(7): 489–95

    Article  PubMed  CAS  Google Scholar 

  37. Briegel J, Schelling G, Haller M et al. (1996) A comparison of the adrenocortical response during septic shock and after complete recovery. Intensive Care Med 22(9): 894–9

    Article  PubMed  CAS  Google Scholar 

  38. Hamrahian AH, Oseni TS, Arafah BM (2004) Measurements of serum free cortisol in critically ill patients. N Engl J Med. 350(16): 1629–38 39

    Article  PubMed  CAS  Google Scholar 

  39. Marik PE, Pastores SM, Annane D et al. (2008) Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 36(6): 1937–49

    Article  PubMed  CAS  Google Scholar 

  40. Mauro Perretti (2007) Glucocorticoids in innate immunity: more transactivation than transrepression! Blood 109: 852–3

    Google Scholar 

  41. Barber AE, Coyle SM, Marano MA et al. (1993) Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man. J Immunol 150(5): 1999–2006

    PubMed  CAS  Google Scholar 

  42. Bhagat K, Collier J, Vallance P (1996) Local venous responses to endotoxin in humans. Circulation 94(3): 490–7

    Article  PubMed  CAS  Google Scholar 

  43. Annane D, Sebille V, Charpentier C et al. (2002) Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. Jama 288(7): 862–71

    Article  PubMed  CAS  Google Scholar 

  44. Briegel J, Forst H, Haller M et al. (1999) Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit Care Med 27(4): 723–32

    Article  PubMed  CAS  Google Scholar 

  45. Bollaert PE, Charpentier C, Levy B et al. (1998) Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 26(4): 645–50

    Article  Google Scholar 

  46. Bellissant E, Annane D (2000) Effect of hydrocortisone on phenylephrine—mean arterial pressure dose-response relationship in septic shock. Clin Pharmacol Ther 68(3): 293–303

    Article  PubMed  CAS  Google Scholar 

  47. Annane D, Bellissant E, Sebille V et al. (1998) Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve. Br J Clin Pharmacol 46(6): 589–97

    Article  PubMed  CAS  Google Scholar 

  48. Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348(2): 138–50

    Article  PubMed  CAS  Google Scholar 

  49. Sprung CL, Annane D, Keh D et al. (2008) Hydrocortisone therapy for patients with septic shock. CORTICUS Study Group. N Engl J Med 358(2): 111–24

    Article  PubMed  CAS  Google Scholar 

  50. Annane D, Bellissant E, Bollaert PE et al. (2009) Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review. JAMA 301(22): 2362–75

    Article  PubMed  CAS  Google Scholar 

  51. Annane D, Cariou A, Maxime V et al. (2010) Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial. COIITSS Study Investigators. JAMA 303(4):341–8

    Article  PubMed  Google Scholar 

  52. Marik PE, Pastores SM, Annane D et al. (2008) Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 36(6): 1937–49

    Article  PubMed  CAS  Google Scholar 

  53. Surviving Sepsis Campaign (2008) International guidelines for management of severe sepsis and septic shock. Crit Care Med 36(1): 296–327 Erratum in: Crit Care Med 2008 Apr 36(4):1394-6

    Article  Google Scholar 

  54. Annane D, Bellissant E, Cavaillon JM (2005) Septic shock. Lancet 1–7 365(9453): 63–78

    Article  PubMed  CAS  Google Scholar 

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  1. V. Maxime
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  2. H. Prigent
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  3. D. Annane
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Maxime, V., Prigent, H., Annane, D. (2011). Interférences avec l’axe corticotrope. In: Sepsis grave et choc septique. Le point sur …. Springer, Paris. https://doi.org/10.1007/978-2-8178-0064-6_19

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  • DOI: https://doi.org/10.1007/978-2-8178-0064-6_19

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0063-9

  • Online ISBN: 978-2-8178-0064-6

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