Skip to main content
SpringerLink
Log in

Définitions du sepsis et concept PIRO

  • Chapter
Sepsis grave et choc septique

Part of the book series: Le point sur … ((POINT))

  • 693 Accesses

Résumé

Le concept de SIRS (syndrome inflammatoire de réponse systémique) est aujourd’hui largement adopté par les médecins et les chercheurs. Ainsi, une recherche Medline entre janvier et mai 2002 trouvait près de 800 publications comportant le terme SIRS. Bone et al. ont proposé de définir le sepsis comme l’association d’un SIRS à une infection, le sepsis sévère comme un sepsis avec dysfonction d’au moins un organe, hypoperfusion ou hypotension, et le choc septique comme un sepsis avec hypotension artérielle persistante en dépit d’une expansion volémique adaptée (1). La pertinence de ces définitions a été discutée et il est proposé de les modifier afin de mieux refléter nos nouvelles connaissances sur la physiopathologie de ces syndromes (2). Dans ce but, une nouvelle conférence internationale s’est déroulée en 2001, sous l’égide des principales sociétés savantes concernées (SCCM/ Esicm/ACCP/ATS/Sis) pour proposer de nouvelles définitions (3).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Réfénces

  1. Bone RC (1995) Sepsis, sepsis syndrome, and the systemic Inflammatory response syndrome (SIRS). Gulliver in Laputa. JAMA 273: 155–6

    Article  PubMed  CAS  Google Scholar 

  2. Marshall JC (2000) SIRS and MODS: What is their relevance to the science and practice of intensive care? Shock 14: 586–9

    Article  PubMed  CAS  Google Scholar 

  3. Levy MM, Fink MP, Marshall JC et al. (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 31: 1250–6

    Article  PubMed  Google Scholar 

  4. Members of the American College of Chest Physicians/Society of Crit Care Med Consensus Conference Committee: American College of Chest Physicians/Society of Crit Care Med Consensus Conference (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20: 864–74

    Google Scholar 

  5. Taniguchi T, Koido Y, Aiboshi J et al. (1999) Change in the ratio of interleukin-6 to interleukin-10 predicts a poor outcome in patients with systemic Inflammatory response syndrome. Crit Care Med 27: 1262–4

    Article  PubMed  CAS  Google Scholar 

  6. Ueda S, Nishio K, Minamino N et al. (1999) Increased plasma levels of adrenomedullin in patients with systemic Inflammatory response syndrome. Am J Respir Crit Care Med 160: 132–6

    Article  PubMed  CAS  Google Scholar 

  7. Stoiser B, Knapp S, Thalhammer F et al. (1998) Time course of immunological markers in patients with the systemic Inflammatory response syndrome: Evaluation of sCD14, sVCAM-1, sELAM-1, MIP-1 alpha and TGF-beta 2. Eur J Clin Invest 28: 672–8

    Article  PubMed  CAS  Google Scholar 

  8. Hietaranta A, Kemppainen E, Puolakkainen P et al. (2002) Extracellular phospholipases A2 in relation to systemic Inflammatory response syndrome (SIRS) and systemic complications in severe acute pancreatitis. Pancreas 18: 385–91

    Article  Google Scholar 

  9. Takala A, Jousela I, Olkkola KT et al. (1999) Systemic Inflammatory response syndrome without systemic inflammation in acutely ill patients admitted to hospital in a medical emergency. Clin Sci (Lond) 96: 287–95

    Article  CAS  Google Scholar 

  10. Sablotzki A, Borgermann J, Baulig W et al. (2001) Lipopolysaccharide-binding protein (LBP) and markers of acute-phase response in patients with multiple organ dysfunction syndrome (MODS) following open heart surgery. Thorac Cardiovasc Surg 49: 273–8

    Article  PubMed  CAS  Google Scholar 

  11. Harbarth S, Holeckova K, Froidevaux C et al. (2001) Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 164: 340–96

    Article  Google Scholar 

  12. Duflo F, Debon R, Monneret G et al. (2002) Alveolar and serum procalcitonin: Diagnostic and prognostic value in ventilator-associated pneumonia. Anesthesiology 96: 74–9

    Article  PubMed  CAS  Google Scholar 

  13. Angus DC, Linde-Zwirble WT, Lidicer J et al. (2001) Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 29: 1303–10

    Article  PubMed  CAS  Google Scholar 

  14. Marshall JC, Cook DJ, Christou NV et al. (1995) Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome. Crit Care Med 23: 1638–52

    Article  PubMed  CAS  Google Scholar 

  15. Ferreira FL, Bota DP, Bross A et al. (2002) Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 286: 1754–8

    Article  Google Scholar 

  16. Carcillo JA, Task Force Members, Fields AI (2002) Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Patients in Septic Shock. Crit Care Med 30: 1–13

    Article  Google Scholar 

  17. Denoix PX (1946) Enquête permanente dans les centres anticancéreux. Bull Inst Natl Hyg 1: 70–5

    Google Scholar 

  18. Gospodarowicz M, Benedet L, Hutter RV et al. (1998) History and international developments in cancer staging. Cancer Prev Cont 2: 262–8

    CAS  Google Scholar 

  19. Renaud B, Brun-Buisson C, ICU-Bacteremia Study Group (2001) Outcomes of primary and catheter-related bacteremia: A cohort and case-control study in critically ill patients. Am J Respir Crit Care Med 163: 1584–90

    Article  PubMed  CAS  Google Scholar 

  20. Opal SM, Cohen J (1999) Clinical gram-positive sepsis: Does it fundamentally differ from gram-negative bacterial sepsis? Crit Care Med 27: 1608–16

    Article  PubMed  CAS  Google Scholar 

  21. Ziegler EJ, Fisher CJ Jr, Sprung CL et al. (1991) Treatment of Gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin: A randomized, double-blind, placebo-controlled trial. N Engl J Med 324: 429–36

    Article  PubMed  CAS  Google Scholar 

  22. Wortel CH, von der Mohlen MAM, van Deventer SJH et al. (1992) Effectiveness of a human monoclonal anti-endotoxin antibody (HA-1A) in gram-negative sepsis: Relationship to endotoxin and cytokine levels. J Infect Dis 166: 1367–74

    Article  PubMed  CAS  Google Scholar 

  23. McCloskey RV, Straube RC, Sanders C et al. (1994) Treatment of septic shock with human monoclonal antibody HA-1A: A randomized, double-blind, placebo-controlled trial. Ann Intern Med 121: 1–5

    Article  PubMed  CAS  Google Scholar 

  24. Hausfater P, Garric S, Ayed SB et al. (2002) Usefulness of procalcitonin as a marker of systemic infection in emergency department patients: A prospective study. Clin Infect Dis 34: 895–901

    Article  PubMed  CAS  Google Scholar 

  25. Damas P, Ledoux D, Nys M et al. (1992) Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg 215: 356–62

    Article  PubMed  CAS  Google Scholar 

  26. Panacek EA, Kaul M (1999) IL-6 as a marker of excessive TNF-alpha activity in sepsis. Sepsis 3: 65–73

    Article  Google Scholar 

  27. Vincent J-L, Moreno R, Takala J et al. (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med 22: 707–10

    Article  PubMed  CAS  Google Scholar 

  28. Marshall JC, Panacek EA, Teoh L et al. (2001) Modeling organ dysfunction as a risk factor, outcome, and measure of biologic Effect in sepsis. Crit Care Med 28: A46

    Google Scholar 

  29. Cook R, Cook DJ, Tilley J et al. (2001) Multiple organ dysfunction: Baseline and serial component scores. Crit Care Med 29: 2046–50

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. I. Boyadjiev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag France

About this chapter

Cite this chapter

Boyadjiev, I., Martin, C. (2011). Définitions du sepsis et concept PIRO. In: Sepsis grave et choc septique. Le point sur …. Springer, Paris. https://doi.org/10.1007/978-2-8178-0064-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-2-8178-0064-6_1

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0063-9

  • Online ISBN: 978-2-8178-0064-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation