Skip to main content
SpringerLink
Log in

Implications des pathologies auto-immunes sur la fertilité et laide médicale à la procréation

  • Chapter
Physiologie, pathologie et thérapie de la reproduction chez l’humain

  • 886 Accesses

Résumé

Le taux d’infertilité est de 10 à 20 %dans les pays occidentaux. Les maladies auto-immunes et, en premier lieu, le lupus érythémateux systémique et le syndrome des antiphospholipides (SAPL) peuvent être en cause par des mécanismes variés : anovulation, ménopause précoce, toxicité gonadique des traitements, pertes foetales par ischémie placentaire ...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. Boumpas DT, Austin HA, Vaughan EM et al. (1993) Risk of sustained amenorrhea in patients with systemic lupus erythematosus receiving intermittent pulse cyclophosphamide therapy. Ann Intern Med 119:366–369

    PubMed  CAS  Google Scholar 

  2. Blumenfeld Z, Avivi I, Eckman A et al. (2008) Gonadotropin-releasing hormone agonist decreases chemotherapy-induced gonadotoxicity and premature ovarian failure in young female patients with Hodgkin lymphoma. Fertil Steril 89:166–173

    Article  PubMed  CAS  Google Scholar 

  3. Somers EC, Marder W, Christman GM et al. (2005) Use of a gonadotropin-releasing hormone analog for protection against premature ovarian failure during cyclophosphamide therapy in women with severe lupus. Arthritis Rheum 52:2761–2767

    Article  PubMed  CAS  Google Scholar 

  4. Cervera R, Balasch J (2008) Bidirectional effects on autoimmunity and reproduction. Hum Reprod Update 14:359–366

    Article  PubMed  CAS  Google Scholar 

  5. Doria A, Tincani A, Lockshin M (2008) Challenges of lupus pregnancies. Rheumatology 47(Suppl 3):iii9–iii12

    Article  PubMed  Google Scholar 

  6. La Rosa L, Covini G, Galperin C et al. (1998) Anti-mitochondrial M5 type antibody represents one of the serological markers for anti-phospholipid syndrome distinct from anti-cardiolipin and anti-β2-glycoprotein I antibodies Clin Exp Immunol 112:144–151

    Article  Google Scholar 

  7. Oliver-Miñarro D, Sanchez-Ramón S, Rodriguez-Mahou M et al. (2007) Isolated type 5 antimitochondrial auto-antibodies are associated with a history of thrombocytopenia and fetal loss. Fertil Steril 87:976.e17-8

    Article  PubMed  Google Scholar 

  8. Carmona F, Balasch J (2002) Fetal and obstetric manifestations and infertility in the antiphospholipid syndrome. In: Asherson RA, Cervera R, Piette JC, Shoenfeld Y, eds. The Antiphospholipid Syndrome II: Autoimmune Thrombosis. Amsterdam, Elsevier:205–211

    Google Scholar 

  9. Yasuda M, Takakuwa K, Tokunaga A, Tanaka K (1995) Prospective studies of the association between anticardiolipin antibody and outcome of pregnancy. Obstet Gynecol 86:555–559

    PubMed  CAS  Google Scholar 

  10. Erkan D, Patel S, Nuzzo M et al. (2008) Management of the controversial aspects of the antiphospholipid syndrome pregnancies: a guide for clinicians and researchers. Rheumatology 47(Suppl 3):iii23–27

    Article  PubMed  Google Scholar 

  11. Geva E, Geva LL, Burke M et al. (2004) Undiagnosed systemic lupus erythematosus in a cohort of infertile women. Am J Reprod Immunol 51:336–340

    Article  PubMed  Google Scholar 

  12. Hornstein MD, Davis OK, Massey JB et al. (2000) Antiphospholipid antibodies and in-vitro fertilization success: a meta-analysis. Fertil Steril 73:330–333

    Article  PubMed  CAS  Google Scholar 

  13. Hoek A, Schoemaker J, Drexhage HA (1997) Premature ovarian failure and ovarian autoimmunity. Endocr Rev 18:107–134

    Article  PubMed  CAS  Google Scholar 

  14. Nelson LM (2009) Clinical practice. Primary ovarian insufficiency. N Engla J Med 360:606–614

    Article  CAS  Google Scholar 

  15. Blumenfeld Z, Halachmi S, Peretz BA et al. (1993) Premature ovarian failure-the prognostic application of autoimmunity on conception after ovulation induction. Fertil Steril 59:750–755

    PubMed  CAS  Google Scholar 

  16. Poppe K, Velkeniers B, Glinoer D; Medscape (2008) The role of thyroid autoimmunity in fertility and pregnancy. Nat Clin Pract Endocrinol Metab 4:394–405

    Article  PubMed  CAS  Google Scholar 

  17. Prummel MF, Strieder T, Wiersinga WM (2004) The environment and auto-immune thyroid diseases. Eur J Endocrinol 150:605–618

    Article  PubMed  CAS  Google Scholar 

  18. Negro R, Formoso G, Mangieri T et al. (2006) Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. J Clin Endocrinol Metab 91:2587–2591

    Article  PubMed  CAS  Google Scholar 

  19. Negro R, Mangieri T, Coppola L et al. (2005) Levothyroxine treatment in thyroid peroxidase antibody-positive women undergoing assisted reproduction technologies: a prospective study. Hum Reprod 20:1529–1533

    Article  PubMed  CAS  Google Scholar 

  20. Abalovich M, Amino N, Barbour LA et al. (2007) Management of thyroid dysfunction during pregnancy and post-partum: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 92(Suppl 8):S1–S47

    PubMed  CAS  Google Scholar 

  21. Negro R, Formoso G, Coppola L et al. (2007) Euthyroid women with autoimnmune disease undergoing assisted reproduction technologies: the role of autoimmunity and thyroid function. J Endocrinol Invest 30:3–8

    PubMed  CAS  Google Scholar 

  22. Meloni GF, Dessole S, Vargiu N et al. (1999) The prevalence of coeliac disease in infertility. Hum Reprod 14:2759–2761

    Article  PubMed  CAS  Google Scholar 

  23. Ciacci C, Tortora R, Scudiero O et al. (2009) Early pregnancy loss in celiac women: The role of genetic markers of thrombophilia. Dig liver Dis 41:717–720

    Article  PubMed  CAS  Google Scholar 

  24. Petri M (2008) Sex hormones and systemic lupus erythematosus. Lupus 17:412–415

    Article  PubMed  CAS  Google Scholar 

  25. Bengtsson AA, Rylander L, Hagmar L et al. (2002) Risk factors for developing systemic lupus erythematosus: a case-control study in southern Sweden. Rheumatology 41:563–571

    Article  PubMed  CAS  Google Scholar 

  26. Cooper GS, Dooley MA, Treadwell EL et al. (2002) Hormonal and reproductive risk factors for development of systemic lupus erythematosus: results of a population-based, case-control study. Arthritis Rheum 46:1830–1839

    Article  PubMed  CAS  Google Scholar 

  27. Costa M, Colia D (2008) Treating infertility in auto-immune patients. Rheumatology 47(Suppl 3):iii38–iii41

    Article  PubMed  Google Scholar 

  28. Le Thi Huong D, Wechsler YY, Piette JC (2003) Ovulation induction therapy and systemic lupus erythematosus. Ann Med Interne 154:45–50

    Google Scholar 

  29. Guballa N, Sammaritano L, Schwartzman S et al. (2000) Ovulation induction and in-vitro fertilization in systemic lupus erythematosus and antiphospholipid syndrome. Arthritis Rheum 43:550–556

    Article  PubMed  CAS  Google Scholar 

  30. Chauvet E, Canet S, Huchard G et al. (2005) Syndrome catastrophique des antiphospholipides après induction de l’ovulation. Rev Med Int 26:956–959

    Article  CAS  Google Scholar 

  31. Koo EJ, Rha JH, Lee BI et al. (2002) A case of cerebral infarct in combined antiphospholipid antibody and ovarian hyperstimulation syndrome. J Korean Med Sci 17:574–576

    PubMed  Google Scholar 

  32. Nargund G, Fauser BCJM, Macklon NS et al. (2007) For the Rotterdam ISMAAR consensus group on terminology for ovarian stimulation for IVF5. The ISMAAR proposal on terminology for ovarian stimulation for IVF. Hum Reprod 22:2801–2804

    Article  PubMed  CAS  Google Scholar 

  33. Heijnen E, Marinus JC, De Klerk C et al (2007) Mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial. Lancet 369:743–749

    Article  PubMed  Google Scholar 

  34. Wilson C, Eade OE, Elstein M et al. (1975) Smooth-muscle antibodies in infertility. Lancet i:238–239

    Google Scholar 

  35. Taylor PV, Campbell JM, Scott JS (1989) Presence of autoantibodies in women with unexplained infertility. Am J Obstet Gynecol 161:377–379

    PubMed  CAS  Google Scholar 

  36. Roussev RG, Kaider BD, Price DE, Coulam CB (1996) Laboratory evaluation of women experiencing reproductive failure. Am J Reprod Immunol 35:415–420

    Article  PubMed  CAS  Google Scholar 

  37. Reimand K, Talja I, Metskula K et al. (2001) Autoantibody studies of female patients with reproductive failure. Reprod Immunol 51:167–176

    Article  CAS  Google Scholar 

  38. Marai I, Carp HJA, Shai S, Shabo R et al. (2004) Autoantibody panel screening in recurrent miscarriages. Am J Reprod Immunol 51:235–240

    Article  PubMed  CAS  Google Scholar 

  39. Shoenfeld Y, Carp HJA, Molina V et al. (2006) Autoantibodies and prediction of reproductive failure. Am J Reprod Immunol 56:337–344

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service de médecine interne Hôpital Jean Verdier (AP-HP), Université Paris 13, Avenue du 14-Juillet, 93140, Bondy

    O. Fain

Authors
  1. O. Fain
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag France, Paris

About this chapter

Cite this chapter

Fain, O. (2011). Implications des pathologies auto-immunes sur la fertilité et laide médicale à la procréation. In: Physiologie, pathologie et thérapie de la reproduction chez l’humain. Springer, Paris. https://doi.org/10.1007/978-2-8178-0061-5_56

Download citation

  • DOI: https://doi.org/10.1007/978-2-8178-0061-5_56

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0060-8

  • Online ISBN: 978-2-8178-0061-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation