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Folliculogenesis and oogenesis in vivo and in vitro, in humans females

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Physiologie, pathologie et thérapie de la reproduction chez l’humain

Résumé

Folliculogenesis in humans is a long-lasting process and its study is of great interest in the field of human reproduction. The exact factors and physiological mechanisms underlying initiation of follicular growth, selection and growth of follicles, and final follicular maturation is not fully understood. Elucidating the cascade of events involved in those developmental processes will help in preventing, diagnosing, treating female reproductive disorders, preserving and restoring female fertility, and achieving pregnancy. Th ere is considerable ongoing research on the regulation of early-stage folliculo-genesis, and recent findings suggest that female laboratory mice produce new oocytes throughout their reproductive lifespan (1). Although this observation challenges the current belief that new follicles are not generated in mammalian ovaries after birth, there is no direct evidence that new oocytes are ever produced in the human adult ovaries. At birth, the human ovary contains the complete number of oocytes that the female will ever have during her reproductive lifespan.

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  1. Department of Obstetrics and Gynecology Reproductive Biology Division, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5

    J. C. Sadeu

  2. Laboratoire de biologie de la reproduction, IFREARES Clinique Saint-Jean Languedoc, 20, route de Revel, 31400, Toulouse

    D. Nogueira

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Sadeu, J.C., Nogueira, D. (2011). Folliculogenesis and oogenesis in vivo and in vitro, in humans females. In: Physiologie, pathologie et thérapie de la reproduction chez l’humain. Springer, Paris. https://doi.org/10.1007/978-2-8178-0061-5_1

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