Résumé
La douleur chronique post-chirurgicale (DCPC) est une entité qui a longtemps été ignorée. Suite à diverses études et articles de revue, la communauté scientifique et les patients ont pris conscience de sa réalité et de sa prévalence [1]. La douleur chronique atteint 20 % de la population européenne et représente un défi thérapeutique : le succès des traitements n’est aujourd’hui acquis que pour un patient sur trois.
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Références
Kehlet H, Jensen TS, Woolf CJ (2006) Persistent postsurgical pain: risk factors and prevention. Lancet 367: 1618–25
Tegeder I, Costigan M, Griffin RS, et al. (2006) GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 12: 1269–77
Campa D, Gioia A, Tomei A, et al. (2008) Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief. Clin Pharmacol Ther 83: 559–66
Mogil JS, Wilson SG, Bon K, et al. (1999) Heritability of nociception. I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain 80: 67–82
Gaveriaux-Ruff C, Kieffer BL (2007) Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases. Pharmacol Ther 113: 619–34
Lacroix-Fralish ML, Ledoux JB, Mogil JS (2007) The Pain Genes Database: An interactive web browser of pain-related transgenic knockout studies. Pain 131: 3–4
Rodriguez PJ, Korostynski M, Kaminska-Chowaniec D, et al. (2006) Comparison of gene expression profiles in neuropathic and inflammatory pain. J Physiol Pharmacol 57: 401–14
Lifton RP (2010) Individual genomes on the horizon. N Engl J Med 362: 1235–6
Norbury TA, MacGregor AJ, Urwin J, et al. (2007) Heritability of responses to painful stimuli in women: a classical twin study. Brain 130: 3041–9
Kim H, Mittal DP, Iadarola MJ, Dionne RA (2006) Genetic predictors for acute experimental cold and heat pain sensitivity in humans. J Med Genet 43: e40
Lotsch J, Geisslinger G, Tegeder I (2009) Genetic modulation of the pharmacological treatment of pain. Pharmacol Ther 124: 168–84
Cox JJ, Reimann F, Nicholas AK, et al. (2006) An SCN9A channelopathy causes congenital inability to experience pain. Nature 444: 894–8
Colson NJ, Fernandez F, Lea RA, Griffiths LR (2007) The search for migraine genes: an overview of current knowledge. Cell Mol Life Sci 64: 331–44
Tegeder I, Lotsch J (2009) Current evidence for a modulation of low back pain by human genetic variants. J Cell Mol Med
Ablin JN, Cohen H, Buskila D (2006) Mechanisms of disease: genetics of fibromyalgia. Nat Clin Pract Rheumatol 2: 671–8
Granot M, Lowenstein L, Yarnitsky D, et al. (2003) Postcesarean section pain prediction by preoperative experimental pain assessment. Anesthesiology 98: 1422–6
Nikolajsen L, Ilkjaer S, Jensen TS (2000) Relationship between mechanical sensitivity and postamputation pain: a prospective study. Eur J Pain 4: 327–34
Bisgaard T, Rosenberg J, Kehlet H (2005) From acute to chronic pain after laparoscopic cholecystectomy: a prospective follow-up analysis. Scand J Gastroenterol 40: 1358–64
Rollason V, Samer C, Piguet V, et al. (2008) Pharmacogenetics of analgesics: toward the individualization of prescription. Pharmacogenomics 9: 905–33
Gasche Y, Daali Y, Fathi M, et al. (2004) Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Engl J Med 351: 2827–31
Klepstad P, Rakvag TT, Kaasa S, et al. (2004) The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand 48: 1232–9
Janicki PK, Schuler G, Francis D, et al. (2006) A genetic association study of the functional A118G polymorphism of the human mu-opioid receptor gene in patients with acute and chronic pain. Anesth Analg 103: 1011–7
Walter C, Lotsch J (2009) Meta-analysis of the relevance of the OPRM1 118A > G genetic variant for pain treatment. Pain 146: 270–5
Lotsch J, Belfer I, Kirchhof A, et al. (2007) Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms. Clin Chem 53: 1010–5
Tegeder I, Adolph J, Schmidt H, et al. (2008) Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype. Eur J Pain 12: 1069–77
Doehring A, Freynhagen R, Griessinger N, et al. (2009) Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care. Clin J Pain 25: 781–5
Lötsch J, Klepstad P, Doehring A, Dale O (2010) A GTP cyclohydrolase 1 genetic variant delays cancer pain. Pain 148: 103–6
Campbell CM, Edwards RR, Carmona C, et al. (2009) Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain. Pain 141: 114–8
Holliday KL, Nicholl BI, Macfarlane GJ, et al. (2009) Do genetic predictors of pain sensitivity associate with persistent widespread pain? Mol Pain 5:56.: 56
Lazarev M, Lamb J, Barmada MM, et al. (2008) Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis? Mol Pain 4:58.: 58
Kim H, Dionne RA (2007) Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans. Mol Pain 3:6.: 6
Doehring A, Antoniades C, Channon KM, et al. (2008) Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk. Mutat Res 659: 195–201
Foulkes T, Wood JN (2008) Pain genes. PLoS Genet 4: e1000086
Kim H, Lee H, Rowan J, et al. (2006) Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans. Mol Pain 2:24.: 24
Kim H, Neubert JK, San MA, et al. (2004) Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain 109: 488–96
Diatchenko L, Slade GD, Nackley AG, et al. (2005) Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 14: 135–43
Diatchenko L, Nackley AG, Slade GD, et al. (2006) Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 125: 216–24
Cohen H, Neumann L, Glazer Y, et al. (2009) The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia. Clin Exp Rheumatol 27: S51–6
Zubieta JK, Heitzeg MM, Smith YR, et al. (2003) COMT Val158Met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science 299: 1240–3
Armero P, Muriel C, Santos J, et al. (2005) COMT (Val158Met) polymorphism is not associated to neuropathic pain in a Spanish population. Eur J Pain 9: 229–32
Hocking LJ, Smith BH, Jones GT, et al. (2010) Genetic variation in the beta2-adrenergic receptor but not catecholamine-O-methyltransferase predisposes to chronic pain: results from the 1958 British Birth Cohort Study. Pain 149: 143–51
Fillingim RB, Wallace MR, Herbstman DM, et al. (2008) Genetic contributions to pain: a review of findings in humans. Oral Dis 14: 673–82
Lotsch J, Stuck B, Hummel T (2006) The human mu-opioid receptor gene polymorphism 118A > G decreases cortical activation in response to specific nociceptive stimulation. Behav Neurosci 120: 1218–24
Huang CJ, Liu HF, Su NY, et al. (2008) Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*. Anaesthesia 63: 1288–95
Mogil JS, Wilson SG, Chesler EJ, et al. (2003) The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci USA 100: 4867–72
Mogil JS, Ritchie J, Smith SB, et al. (2005) Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans. J Med Genet 42: 583–7
Treister R, Pud D, Ebstein RP, et al. (2009) Associations between polymorphisms in dopamine neurotransmitter pathway genes and pain response in healthy humans. Pain 147: 187–93
Reyes-Gibby CC, Spitz MR, Yennurajalingam S, et al. (2009) Role of inflammation gene polymorphisms on pain severity in lung cancer patients. Cancer Epidemiol Biomarkers Prev 18: 2636–42
Potvin S, Larouche A, Normand E, et al. (2009) DRD3 Ser9Gly polymorphism is related to thermal pain perception and modulation in chronic widespread pain patients and healthy controls. J Pain 10: 969–75
Ribeiro-Dasilva MC, Peres L Sr, Leme Godoy dos Santos MC, et al. (2009) Estrogen receptor-alpha polymorphisms and predisposition to TMJ disorder. J Pain 10: 527–33
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Suter, M.R., Decosterd, I. (2013). Facteurs génétiques de prédisposition aux douleurs chroniques post-chirurgicales. In: La douleur chronique post-chirurgicale. Springer, Paris. https://doi.org/10.1007/978-2-8178-0026-4_3
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DOI: https://doi.org/10.1007/978-2-8178-0026-4_3
Publisher Name: Springer, Paris
Print ISBN: 978-2-8178-0025-7
Online ISBN: 978-2-8178-0026-4