Résumé
Le cancer de l’endomètre est le cancer gynécologique le plus fréquent et représente le troisième cancer féminin après le cancer du sein et le cancer colorectal [1]. Le nombre de nouveaux cas a été estimé en France en l’année 2010 à 6 563 cas soit 4,3 % de l’ensemble des cancers féminins et le nombre de décès à 1 900 [2].
Preview
Unable to display preview. Download preview PDF.
Références
Pisani P, Bray F, Parkin DM (2002) Estimates of the world-wide prevalence of cancer for 25 sites in the adult population. Int J Cancer 97: 72–81
Projections de l’incidence et de la mortalité par cancer en France en 2010. http://www.invs.sante.fr/applications/cancers/projections2010/default.htm
Barakat RR, Gilewski TA, Almadrones L et al. (2000) Effect of adjuvant tamoxifen on the endometrium in women with breast cancer: a prospective study using office endometrial biopsy. J Clin Oncol 18: 3459–3463
Greene JL, Page DL, Fleming ID et al. (2002) AJCC cancer staging manual. 6th ed. Berlin: Springer
Trope C, Kristensen GB, Abeler VM (2001) Clear-cell and papillary serous cancer: treatment options. Best Pract Res Clin Obstet Gynaecol 15: 433–446
Wethington SL, Barrena Medel NI, Wright JD, Herzog TJ (2009) Prognostic significance and treatment implications of positive peritoneal cytology in endometrial adenocarcinoma: nraveling a mystery. Gynecol Oncol 115: 18–25. Epub 2009 Jul 26
Baekelandt MM, Castiglione M (2009) ESMO Guidelines Working Group. Endometrial carcinoma: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 20Suppl 4: 29–31
Santin AD, Bellone S, Van Stedum S et al. (2005) Amplification of c-erbB2 oncogene: a major prognostic indicator in uterine serous papillary carcinoma. Cancer 104: 1391–1397
Pecorelli S (2009) Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 105: 103–104
Yura Y, Tauchi K, Koshiyama M et al. (1996) Parametrial involvement in endometrial carcinomas: its incidence and correlation with other histological parameters. Gynecol Oncol 63: 114–119
Kilgore LC, Partridge EE, Alvarez RD et al. (1995) Adenocarcinoma of the endometrium: survival comparisons of patients with and without pelvic node sampling. Gynecol Oncol 56: 29–33
Chuang L, Burke TW, Tornos C et al. (1995) Staging laparotomy for endometrial carcinoma: assessment of retroperitoneal lymph nodes. Gynecol Oncol 58: 189–193
ASTEC study group, Kitchener H, Swart AM, Qian Q et al. (2009) Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet 373: 125–136
Ahmad K, Kim YH, Deppe G et al. (1989) Stage III carcinoma of the endometrium. Results of treatment. Eur J Gynaecol Oncol 10: 383–389
Chi DS, Welshinger M, Venkatraman ES, Barakat RR (1997) The role of surgical cytoreduction in Stage IV endometrial carcinoma. Gynecol Oncol 67: 56–60
Baekelandt MM, Castiglione M (2008) Endometrial carcinoma: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 19Suppl 2: 19–20
Blake P, Swart AM, Orton J et al. (2009) Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and metaanalysis. Lancet 373: 137–146
Creutzberg CL, van Putten WL, Koper PC et al. (2000) Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet 355: 1404–1411
Keys HM, Roberts JA, Brunetto VL, et al. (2004) A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 92: 744–751
Creutzberg CL, van Putten WL, Koper PC et al. (2001) The morbidity of treatment for patients with Stage I endometrial cancer: results from a randomized trial. Int J Radiat Oncol Biol Phys 51: 1246–1255
Nout RA, Smit VT, Putter et al. Portec Study group (2010) Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomized trial. Lancet 375: 816–823
Nout RA, Putter H, Jurgenliemk-Schulz IM et al. (2009) Quality of life after pelvic radiotherapy or vaginal brachytherapy for endometrial cancer: first results of the randomized PORTEC-2 trial. J Clin Oncol 27: 3547–3556
Lian J, Mackenzie M, Joseph K et al. (2008) Assessment of extended-field radiotherapy for stage IIIC endometrial cancer using three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, and helical tomotherapy. Int J Radiat Oncol Biol Phys 70: 935–943
Creutzberg CL, van Putten WL, Warlam-Rodenhuis CC et al. (2004) Outcome of high-risk stage IC, grade 3, compared with stage I endometrial carcinoma patients: the Postoperative Radiation Therapy in Endometrial Carcinoma Trial. J Clin Oncol 22: 1234–1241
Greven K, Winter K, Underhill K et al. (2006) Final analysis of RTOG 9708: adjuvant postoperative irradiation combined with cisplatin/paclitaxel chemotherapy following surgery for patients with high-risk endometrial cancer. Gynecol Oncol 103: 155–159
Briet JM, Hollema H, Reesink N et al. (2005) Lymphvascular space involvement: an independent prognostic factor in endometrial cancer. Gynecol Oncol 96: 799–804
Fishman DA, Roberts KB, Chambers JT et al. (1996) Radiation therapy as exclusive treatment for medically inoperable patients with stage I and II endometrioid carcinoma with endometrium. Gynecol Oncol 61: 189–196
Singh M, Zaino RJ, Filiaci VJ, Leslie KK (2007) Relationship of estrogen and progesterone receptors to clinical outcome in metastatic endometrial carcinoma: a Gynecologic Oncology Group Study. Gynecol Oncol 106: 325–333
Thigpen JT, Brady MF, Alvarez RD et al. (1999) Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group. J Clin Oncol 17: 1736–1744
Thigpen JT, Brady MF, Homesley HD (2001) Tamoxifen in the treatment of advanced or recurrent endometrial carcinoma: a Gynecologic Oncology Group study. J Clin Oncol 19, pp. 364–367
Whitney CW, Brunetto VL, Zaino RJ et al. (2004) Gynecologic Oncology Group study. Phase II study of medroxyprogesterone acetate plus tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 92: 4–9
Fiorica JV, Brunetto VL, Hanjani P et al. (2004) Gynecologic Oncology Group study. Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 92: 10–14
Ma BB, Oza A, Eisenhauer E et al. (2004) The activity of letrozole in patients with advanced or recurrent endometrial cancer and correlation with biological markers—a study of the National Cancer Institute of Canada Clinical Trials Group. Int J Gynecol Cancer 14: 650–658
Lhommé C, Vennin P, Callet N et al. (1999) Gynecol Oncol. A multicenter phase II study with triptorelin (sustained-release LHRH agonist) in advanced or recurrent endometrial carcinoma: a French anticancer federation study. Gynecol Oncol 75: 187–193
Martin-Hirsch PL, Lilford RJ, Jarvis GJ (1996) Adjuvant progestagen therapy for the treatment of endometrial cancer: review and meta-analyses of published randomised controlled trials. Eur J Obstet Gynecol Reprod Biol 65: 201–207
Urbaski K, Karolewski K, Kojs Z et al. (1993) Adjuvant progestagen therapy improves survival in patients with endometrial cancer after hysterectomy. Results of one-institutional prospective clinical trial. Eur J Gynaecol Oncol 14 Suppl: 98–104
Vishnevsky AS, Bokhman YaV, Loutfi G (1993) Favourable influence of adjuvant hormone therapy by oxyprogesterone caproate (OPC) and by its combination with tamoxifen on 5-year survival rate of surgical and combined treatment of primary endometrial carcinoma patients. Eur J Gynaecol Oncol 14: 150–153
Fleming GF (2007) Systemic chemotherapy for uterine carcinoma: metastatic and adjuvant. J Clin Oncol 25: 2983–2990
Thigpen JT, Blessing JA, DiSaia PJ et al. (1994) A randomized comparison of doxorubicin alone versus doxorubicin plus cyclophosphamide in the management of advanced or recurrent endometrial carcinoma: A Gynecologic Oncology Group study. J Clin Oncol 12: 1408–1414
Aapro MS, van Wijk FH, Bolis G et al. (2003) European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group. Doxorubicin versus doxorubicin and cisplatin in endometrial carcinoma: definitive results of a randomised study (55872) by the EORTC Gynaecological Cancer Group. Ann Oncol 14: 441–448
Thigpen JT, Brady MF, Homesley HD et al. (2004) Phase III trial of doxorubicin with or without cisplatin in advanced endometrial carcinoma: a gynecologic oncology group study. J Clin Oncol 22: 3902–3908
Fleming GF, Filiaci VL, Bentley RC et al. (2004) Phase III randomized trial of doxorubicin + cisplatin versus doxorubicin + 24-h paclitaxel + filgrastim in endometrial carcinoma: a Gynecologic Oncology Group study. Ann Oncol 15: 1173–1178
Fleming GF, Brunetto VL, Cella D et al. (2004) Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol 22: 2159–2166
Sorbe B, Andersson H, Boman K et al. (2008) Treatment of primary advanced and recurrent endometrial carcinoma with a combination of carboplatin and paclitaxel-long-term follow-up. Int J Gynecol Cancer 18: 803–808
Randall ME, Filiaci VL, Muss H et al. (2006) Randomized phase III trial of wholeabdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group study. J Clin Oncol 24: 36–44
Maggi R, Lissoni A, Spina F et al. (2006) Adjuvant chemotherapy vs radiotherapy in highrisk endometrial carcinoma: results of a randomised trial. Br J Cancer 95: 266–271
Susumu N, Sagae S, Udagawa Y et al. (2008) Japanese Gynecologic Oncology Group. Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate-and high-risk endometrial cancer: a Japanese Gynecologic Oncology Group study. Gynecol Oncol 108: 226–233
Oza AM, Elit L, Biagni J, Chapman et al. (2006) Molecular correlates associated with a phase II study of temsirolimus (CCI-779) in patients with metastatic or recurrent endometrial cancer. J Clin Oncol 24: 3003
Aghajanian C, Sill MW, Darcy K, Greer B et al. (2009) A phase II evaluation of bevacizumab in the treatment of recurrent or persistent endometrial cancer. A Gynecologic Oncology Group study. J Clin Oncol 27: 5531
Fleming GF, Still MW, Darcy KM et al. (2010) Phase II trial of trastuzumab in women with advanced or recurrent, HER2-positive endometrial carcinoma: a Gynecologic Oncology Group Study. Gynecol Oncol 116: 15–20
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag France
About this chapter
Cite this chapter
Tazi, Y., Mazeron, R., Gouy, S., Pautier, P. (2011). Cancer de l’endomètre. In: Thérapeutique du cancer. Springer, Paris. https://doi.org/10.1007/978-2-8178-0021-9_32
Download citation
DOI: https://doi.org/10.1007/978-2-8178-0021-9_32
Publisher Name: Springer, Paris
Print ISBN: 978-2-8178-0020-2
Online ISBN: 978-2-8178-0021-9