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Hyperglycémie en réanimation

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Résumé

L’hyperglycémie de stress, définie par une hyperglycémie transitoire lors de pathologies aiguës chez des patients non diabétiques, est fréquemment observée chez les patients de réanimation (1). La corrélation entre hyperglycémie de stress et mauvais pronostic est largement établie. En 2001, une grande étude randomisée contrôlée monocentrique, chez des patients de réanimation majoritairement chirurgicaux, montrait que le contrôle glycémique strict par insulinothérapie intensive diminuait la mortalité et le taux de complications en réanimation (2). Cependant, les études ultérieures réalisées dans d’autres services de réanimation n’ont pas pu reproduire un tel bénéfice avec ce type de traitement (3–7).

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Références

  1. Dungan KM, Braithwaite SS, Preiser JC (2009) Stress hyperglycaemia. Lancet 373: 1798–807

    Article  PubMed  CAS  Google Scholar 

  2. Van den Berghe G, Wouters P, Weekers F et al. (2001) Intensive insulin therapy in critically ill patients. N Engl J Med 345: 1359–67

    Article  PubMed  Google Scholar 

  3. Arabi YM, Dabbagh OC, Tamim HM et al. (2008) Intensive versus conventional insulin therapy: A randomzed controlled trial in medical and surgical critically ill patients. Crit Care Med 36: 3190–7

    Article  PubMed  CAS  Google Scholar 

  4. De la Rosa GC, Donado JH, Restrepo AH et al. (2008) Strict glycemic control in patients hospitalized in a mixed medical and surgical intensive care unit: a randomized clinical trial. Crit Care 12: R120

    Article  Google Scholar 

  5. Brunkhorst FM, Engel C, Bloos F et al. (2008) Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis. N Engl J Med 358: 125–39

    Article  PubMed  CAS  Google Scholar 

  6. Preiser JC, Devos P, Ruiz-Santana S et al. (2009) A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: The Glucontrol study. Intensive Care Med 35: 1738–48

    Article  PubMed  CAS  Google Scholar 

  7. The NICE-SUGAR Study Investigators, Finfer S, Chittock DR, Su SY et al. (2009) Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360: 1283–97

    Article  PubMed  Google Scholar 

  8. Von Cromphaut SJ (2009) Hyperglycemia as a part of the stress response: the underlying mechanisms. Best Pract Clin Anaesth 23: 375–86

    Article  Google Scholar 

  9. Scheepers A, Joost HG, Scürmann A (2004) The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. J Parenter Enter Nutr 28: 365–74

    Article  Google Scholar 

  10. Van den Berghe G (2004) How does blood glucose control with insulin save lives in intensive care? J Clin Invest 114: 1187–95

    PubMed  Google Scholar 

  11. Petersen KF, Shulman GI (2006) Etiology of insulin resistance. Am J Med 119 (Suppl 1): S 10–16

    Article  Google Scholar 

  12. Bagry HS, Raghavendran S, Carli F (2008) Metabolic syndrome and insulin resistance: Perioperative considerations. Anesthesiology 108: 506–23

    Article  PubMed  CAS  Google Scholar 

  13. Zauner A, Nimmerichter P, Anderwald C et al. (2007) Severity of insulin resistance in critically ill medical patients. Metabolism 56: 1–5

    Article  PubMed  CAS  Google Scholar 

  14. Wellen KE, Hotamisligil GS (2005) Inflammation, stress, and diabetes. J Clin Invest 115: 1111–9

    PubMed  CAS  Google Scholar 

  15. Leverve X (2003) Hyperglycemia and oxidative stress: complex relationships with attractive prospects. Intensive Care Med 29: 511–4

    PubMed  Google Scholar 

  16. Vanhoerebeek I, Langouche L (2009) Molecular mechanisms behind clinical benefits of intensive insulin therapy during critical illness: glucose versus insulin. Best Pract Res Clin Anaesth 23: 449–59

    Article  Google Scholar 

  17. He J, Usui I, Ishizuka K Kanatani Y et al. (2006) Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes. Mol Endocrinol 20: 114–24

    Article  PubMed  CAS  Google Scholar 

  18. Weekers F, Giuletti AP, Michalaki M. et al. (2003) Metabolic, endocrine, and immune effects of stresss hyperglycemia in rabbit model of prolonged critical illness. Endocrinology 144: 5329–38

    Article  PubMed  CAS  Google Scholar 

  19. Turina M, Fry DE, Polk HC Jr (2005) Acute hyperglycemia and the innate immune system. Crit Care Med 33: 1624–33

    Article  PubMed  Google Scholar 

  20. Vanhorebeek I, De Vos R, Mesotten D, Wouters PJ, De Wolf-Peeters C, Van den Berghe G (2005) Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 365: 53–9

    Article  PubMed  CAS  Google Scholar 

  21. Avromaglu RK, Basciano H, Adeli K (2006) Lipid and lipoprotein dysregulation in insulin resistant states. Clin Chim Acta 368: 1–19

    Article  Google Scholar 

  22. Furnary AP, YingXing W (2006) Eliminating the diabetic disadvantage: The Portland Diabetic Project. Semin Thorac Cardiovasc Surg 18: 302–8

    Article  PubMed  Google Scholar 

  23. Lazar HL, McDonnell M, Chipkin SR et al. (2009) The society of thoracic surgeons practice guideline series: blood glucose management during adult cardiac surgery. Ann Thorac Surg 87: 663–9

    Article  PubMed  Google Scholar 

  24. Doenst T, Wijeysundera D et al. (2005) Hyperglycemia during cardiopulmonary bypass is an independent risk factor for mortality in patients undergoing cardiac surgery. J Thor Cardiovasc Surg 130: 1144–9

    Article  Google Scholar 

  25. D’Alessandro C, Leprince P, Golmard JL et al. (2007) Strict glycemic control reduces EuroSCORE expected mortality in diabetic patients undergoing myocardial revascularization. J Thorac Cardiovasc Surg 134: 29–37

    Article  PubMed  Google Scholar 

  26. Ouattara A, Lecomte P, Le Manach Y et al. (2005) Poor intraoperative blood glucose control is associated with a worsened hospital outcome after cardiac surgery in diabetic patients. Anesthesiology 103: 687–94

    Article  PubMed  CAS  Google Scholar 

  27. Butterworth J, Wagenknecht LE, Legault C et al. (2005) Attempted control of hyperglycemia during cardiopulmonary bypass fails to improve neurologic and neurobehavioral outcomes in patients without diabetes mellitus undergoing coronary artery bypass grafting. J Cardiovasc Surg 130: 1319–25

    Google Scholar 

  28. Malmstedt J, Wahlberg E, Jorneskog G, Swedenborg J (2006) Influence of perioperative blood glucose levels on outcome after infrainguinal bypass surgery in patients with diabetes. Br J Surg 93: 1360–7

    Article  PubMed  CAS  Google Scholar 

  29. Vriesendorp TM, DeVries JH, Hulscher JBF, Holleman F, van Lanschot JJ, Hoekstra JBL (2004) Early postoperative hyperglycaemia is not a risk factor for infectious complications and prolonged in-hospital stay in patients undergoing oesophagectomy: a retrospective analysis of prospective trial. Crit Care 8: R437–42

    Article  PubMed  Google Scholar 

  30. Marchant MH, Viens NA, Vail TP, Bolognesi MP (2009) The impact of glycemic control and diabetes mellitus on perioperative outcomes after total joint arthroplasty. J Bone Joint Surg 91: 1621–9

    Article  PubMed  Google Scholar 

  31. Falciglia M, Freyberg RW, Almenoff PL, D’Alessio DA, Render ML (2009) Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. Crit Care Med 37: 3001–9

    Article  PubMed  CAS  Google Scholar 

  32. Cao JJ, Hudson M, Jankowski M, Whitehouse F, Weaver D (2005) Relation of chronic and acute glycemic control on mortality in acute myocardial infarction with diabetes mellitus. Am J Cardiol 96: 183–6

    Article  PubMed  Google Scholar 

  33. Worthley MI, Shrive FM, Anderson TJ, Traboulsi M (2007) Prognostic implication of hyperglycemia in myocardial infarction and primary angioplasty. Am J Med 120: 643 e1–7

    Article  PubMed  Google Scholar 

  34. Petursson P, Herlitz J, Caidahl K et al. (2007) Admission glycaemia and outcome after acute coronary syndrome. Int J Cardiol 116: 315–20

    Article  PubMed  CAS  Google Scholar 

  35. Stöllberger C, Exner I, Finsterer J, Slany J, Steger C (2005) Stroke in diabetic and non-diabetic patients: course and prognostic value of admission serum glucose. Ann Med 37: 357–64

    Article  PubMed  Google Scholar 

  36. Fogelholm R, Murros K, Rissanen A, Avikainen S (2005) Admission blood glucose and short term survival in primary intracerebral haemorrhage: a population based study. J Neurol Neurosurg Psychiatry 76: 349–53

    Article  PubMed  CAS  Google Scholar 

  37. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC (2001) Stress hyperglycaemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 32: 2426–32

    Article  PubMed  CAS  Google Scholar 

  38. Freire AX, Bridges L, Umpierrez GE, Kuhl D, Kitabchi AE (2005) Admission hyperglycemia and other risk factors as predictors of hospital mortality in a medical ICU population. Chest 128: 3109–16

    Article  PubMed  Google Scholar 

  39. Whitcomb BW, Pradhan EK, Pittas AG, Roghmann MC, Perencevich EN (2005) Impact of admission hyperglycemia on hospital mortality in various intensive care unit populations. Crit Care Med 33: 2772–7

    Article  PubMed  Google Scholar 

  40. Egi M, Bellomo R, Stachowski E et al. (2008) Blood glucose concentration and outcome of critical illness: the impact of diabetes. Crit Care Med 36: 2249–55

    Article  PubMed  CAS  Google Scholar 

  41. Rady MY, Johnson DJ, Patel BM, Larson JS, Helmers RA (2005) Influence of individual characteristics on outcome of glycemic control in intensive care unit patients with or without diabetes mellitus. Mayo Clin Proc 80: 1558–67

    Article  PubMed  Google Scholar 

  42. Wahl WL, Taddonio M, Maggio PM, Arbabi S, Hemmila MR (2008) Mean glucose values predict trauma patient mortality. J Trauma 65: 42–7

    Article  PubMed  CAS  Google Scholar 

  43. Krinsley JS (2004) Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 79: 992–1000

    Article  PubMed  Google Scholar 

  44. Krinsley JS (2006) Glycemic control, diabetic status, and mortality in a heterogenous population of critically ill patients before and during the era of intensive glycemic management six and one-half years experience at a university-affiliated community hospital. Semin Thorac Cardiovasc Surg 18: 317–25

    Article  PubMed  Google Scholar 

  45. Van den Berghe G, Wilmer A, Hermans G. et al. (2006) Intensive insulin therapy in the medical ICU. N Engl J Med 354: 449–61

    Article  PubMed  Google Scholar 

  46. Lena D, Kalfon P, Preiser JC, Ichai C (2011) Glycemic control in the intensive care unit and during the postoperative period. Anesthesiology 114: 438–44

    Article  PubMed  Google Scholar 

  47. Pittas AG, Siegel RD, Lau J (2006) Insulin therapy and in-hospital mortality in critically ill patients: systematic review and meta-analysis of randomized controlled trials. JPEN 30: 164–72

    Article  CAS  Google Scholar 

  48. Wiener RS, Wiener DC, Larson RJ (2008) Benefits and risks of tight glucose control in critically ill adults. A meta-analysis. JAMA 300: 933–44

    Article  PubMed  CAS  Google Scholar 

  49. Griesdale DEG, de Souza RJ, van Dam RM. et al. (2009) Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ 180: 821–7

    Article  PubMed  Google Scholar 

  50. Marik PE, Preiser JC (2010) Toward understanding tight glycaemic control in the ICU: a systematic review and metaanalysis. Chest 137: 544–51

    Article  PubMed  CAS  Google Scholar 

  51. Ghandi GY, Nuttall GA, Abel MD et al. (2007) Intensive intraoperative insulin therapy versus conventional glucose management during cardiac surgery. Ann Intern Med 146: 233–43

    Google Scholar 

  52. Krinsley JS, Grover A (2007) Severe hypoglycemia in critically ill patients: risk factors and outcomes. Crit Care Med 35: 2262–7

    Article  PubMed  Google Scholar 

  53. Vriesendorp TM, DeVries JH, van Santen S. et al. (2006) Evaluation of short-term consequences of hypoglycemia in an intensive care unit. Crit Care Med 34: 2714–8

    Article  PubMed  CAS  Google Scholar 

  54. Arabi YM, Tamim HM, Rishu A (2009) Hypoglycemia with intensive insulin therapy in critically ill patients: predisposing factors and association with mortality. Crit Care Med 37: 2536–44

    Article  PubMed  CAS  Google Scholar 

  55. Suh, SW, Gum ET, Hamby AM, Chan PH, Swanson RA (2007) Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase. J Clin Invest 117: 910–8

    Article  PubMed  CAS  Google Scholar 

  56. Kosiborod M, Inzucchi SE, Goyal A. et al. (2009) Relationship between spontaenous and iatrogenic hypoglycemia and mortality in patients hospitalized with acute myocardial infarction. JAMA 301: 1556–64

    Article  PubMed  CAS  Google Scholar 

  57. Egi M, Bellomo R, Stachowski E, French CJ, Hart G (2006) Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology 105: 244–52

    Article  PubMed  CAS  Google Scholar 

  58. Krinsley JS (2008) Glycemic variability: a strong independent predictor of mortality in critically ill patients. Crit Care Med 36: 3008–13

    Article  PubMed  CAS  Google Scholar 

  59. Ali NA, O’Brien JM, Dungan K et al. (2008) Glucose variability and mortality in patients with sepsis. Crit Care Med 36: 2316–21

    Article  PubMed  Google Scholar 

  60. Dossett LA, Cao H, Mowery NT, Dortch MJ, Morris JM, May AK (2008) Blood glucose variability is associated with mortality in the surgical intensive care unit. Ann Surg 74: 679–85

    Google Scholar 

  61. Dungan K, Chapman J, Braithwaithe SS, Buse J (2007) Glucose measurement: confounding issues in setting targets for inpatients management. Diabetes Care 30: 403–9

    Article  PubMed  Google Scholar 

  62. D’Orazio P, Burnett RW, Fogh-Andersen N et al. (2006) Approved IFCC recommendation on reporting results for blood glucose: International Federation of Clinical Chemistry and Laboratory Medicine Scientific Division, Working Group on Selective Electrodes and Point-of-Care testing (IFCC-SD-SEPOCT). Clin Chem Lab Med 44: 1486–90

    Article  PubMed  Google Scholar 

  63. Desachy A, Vuagnat AC, Ghazali AD et al. (2008) Accuracy of bedside glucometry in critically ill patients: influence of clinical characteristics and perfusion index. Mayo Clin Proc 83: 400–5

    Article  PubMed  CAS  Google Scholar 

  64. Critchell CD, Savarese V, Callahan A, Aboud C, Jabbour S, Marik P (2007) Accuracy of bedside capillary blood glucose measurements in critically ill patients. Intensive Care Med 33: 2079–84

    Article  PubMed  CAS  Google Scholar 

  65. Van den Berghe G, Wilmer W, Milans et al. (2006) Intensive insulin therapy in mixed medical/surgical intensive care units: benefit versus harm. Diabetes 55: 3151–9

    Article  PubMed  Google Scholar 

  66. Furnary AP (2009) Clinical benefits of tight glycaemic control: focus on the perioperative setting. Best Pract Clin Anaesth 23: 411–20

    Article  CAS  Google Scholar 

  67. Vespa P, McArthur D, O’Phelan, Glenn Tl. et al. (2003) Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J Cereb Blood Flow Metab 23: 865–77

    Article  PubMed  CAS  Google Scholar 

  68. Vespa P, Boonyaputthikul R, McArthur DL et al. (2006) Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury. Crit Care Med 34: 850–6

    Article  PubMed  CAS  Google Scholar 

  69. Liu-DeRyke X, Collingridge DS, Orme J, Roller D, Zurasky J, Rohney DH (2009) Clinical impact of early hyperglycemia during acute phase of traumatic brain injury. Neurocrit Care 11: 151–7

    Article  PubMed  Google Scholar 

  70. Singer P, Berger MM, Van den Berghe G et al. (2009) ESPEN Guidelines on Parenteral Nutrition: intensive care. Clin Nutr 28: 387–400

    Article  PubMed  Google Scholar 

  71. Moghissi ES, Korythowski MT, DiNardo M et al. (2009) American Association of clinical endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Endocr Pract 15: 1–17

    Article  Google Scholar 

  72. Ichai C, Preiser JC, for the SFAR, SRLF and expert panel (2010) International recommendations for glucose control in adult non diabetic critically ill patients. Crit Care 14: R166

    PubMed  Google Scholar 

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Orban, JC., Lena, D., Preiser, JC., Ichai, C. (2011). Hyperglycémie en réanimation. In: Désordres métaboliques et réanimation. Le point sur .... Springer, Paris. https://doi.org/10.1007/978-2-287-99027-4_19

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  • DOI: https://doi.org/10.1007/978-2-287-99027-4_19

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