Skip to main content
SpringerLink
Log in

Bouffées de chaleur

  • Chapter
Book cover Aider á vivre aprés un cancer

Part of the book series: Oncologie pratique ((ONCOLPRAT))

  • 394 Accesses

Résumé

Dans le cancer du sein, la chirurgie est la pierre angulaire du traitement. Néanmoins, des traitements adjuvants comme la chimiothérapie ou l’hormonothérapie sont nécessaires pour éradiquer les micrométastases. Ces traitements sont á l’origine de plusieurs effets secondaires. Parmi ces effets secondaires, la ménopause précoce est fréquente, de l’ordre de 53 % á 89 % aprés chimiothérapie (1–3). Chez les femmes non ménopausées avec des tumeurs hormonosensibles, le bénéfice de l’hormonothérapie en termes de survie globale en association aux autres traitements a été démontré. L’hormonothérapie correspond soit á des traitements suppresseurs de la fonction ovarienne par castration (chirurgie, radiothérapie ou agonistes de la luteinizing hormone-releasing hormone [LHRH]), soit aux antioestrogénes ou antiaromatases (4). Ces traitements ont donc comme conséquence d’induire des symptômes de la ménopause précoce: bouffées de chaleur, atrophie génito-urinaire, troubles psychologiques (2, 5, 6). Les bouffées de chaleur sont trés fréquentes chez les femmes non ménopausées traitées pour un cancer du sein et elles sont invalidantes. En effet, elles diminuent la qualité de vie et la qualité du sommeil (7, 8), d’oú l’importance d’informer les patientes sur les traitements pharmacologiques et non pharmacologiques que l’on peut leur proposer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. Del Mastro L, Venturini M, Sertoli MR, et al. (1997) Amenorrhea induced by adjuvant chemotherapy in early breast cancer patients: prognostic role and clinical implications. Breast Cancer Res Treat 43(2): 183–90

    Article  PubMed  Google Scholar 

  2. Goodwin PJ, Ennis M, Pritchard KI, et al. (1999) Risk of menopause during the first year after breast cancer diagnosis. J Clin Oncol 17(8): 2365–70

    PubMed  CAS  Google Scholar 

  3. Shapiro CL, Recht A (2001) Side effects of adjuvant treatment of breast cancer. N Engl J Med 344(26): 1997–2008

    Article  PubMed  CAS  Google Scholar 

  4. Boccardo F, Rubagotti A, Perrotta A, et al. (1994) Ovarian ablation versus goserelin with or without tamoxifen in pre-perimenopausal patients with advanced breast cancer: results of a multicentric Italian study. Ann Oncol 5(4): 337–42

    PubMed  CAS  Google Scholar 

  5. Couzi RJ, Helzlsouer KJ, Fetting JH (1995) Prevalence of menopausal symptoms among women with a history of breast cancer and attitudes toward estrogen replacement therapy. J Clin Oncol 13(11): 2737–44

    PubMed  CAS  Google Scholar 

  6. Ganz PA (2001) Impact of tamoxifen adjuvant therapy on symptoms, functioning, and quality of life. J Natl Cancer Inst Monogr (30): 130–4

    Article  PubMed  Google Scholar 

  7. Savard J, Davidson JR, Ivers H, et al. (2004) The association between nocturnal hot flashes and sleep in breast cancer survivors. J Pain Symptom Manage 27(6): 513–22

    Article  PubMed  Google Scholar 

  8. Day R, Ganz PA, Costantino JP, et al. (1999) Health-related quality of life and tamoxifen in breast cancer prevention: a report from the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Clin Oncol 17(9): 2659–69

    PubMed  CAS  Google Scholar 

  9. Finck G, Barton DL, Loprinzi CL, et al. (1998) Defi nitions of hot flashes in breast cancer survivors. J Pain Symptom Manage 16(5): 327–33

    Article  PubMed  CAS  Google Scholar 

  10. Kronenberg F (1994) Hot flashes: phenomenology, quality of life, and search for treatment options. Exp Gerontol 29(3–4): 319–36

    Article  PubMed  CAS  Google Scholar 

  11. Stearns V, Ullmer L, López JF, et al. (2002) Hot flushes. Lancet 360(9348): 1851–61

    Article  PubMed  CAS  Google Scholar 

  12. Shanafelt TD, Barton DL, Adjei AA, et al. (2002) Pathophysiology and treatment of hot flashes. Mayo Clin Proc 77(11): 1207–18

    Article  PubMed  CAS  Google Scholar 

  13. Kronenberg F (1990) Hot flashes: epidemiology and physiology. Ann N Y Acad Sci 592: 52–86; discussion 123-33

    Article  PubMed  CAS  Google Scholar 

  14. Mohyi D, Tabassi K, Simon J (1997) Differential diagnosis of hot flashes. Maturitas 27(3): 203–14

    Article  PubMed  CAS  Google Scholar 

  15. Schnirer II, Yao JC, Ajani JA (2003) Carcinoid—a comprehensive review. Acta Oncol 42(7): 672–92

    Article  PubMed  Google Scholar 

  16. Fallowfield L, Fleissig A, Edwards R, et al. (2001) Tamoxifen for the prevention of breast cancer: psychosocial impact on women participating in two randomized controlled trials. J Clin Oncol 19(7): 1885–92

    PubMed  CAS  Google Scholar 

  17. Fisher B, Costantino J, Redmond C, et al. (1989) A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors. N Engl J Med 320(8): 479–84

    Article  PubMed  CAS  Google Scholar 

  18. Love RR, Cameron L, Connell BL, et al. (1991) Symptoms associated with tamoxifen treatment in postmenopausal women. Arch Intern Med 151(9): 1842–7

    Article  PubMed  CAS  Google Scholar 

  19. Carpenter JS, Andrykowski MA, Cordova M, et al. (1998) Hot flashes in postmenopausal women treated for breast carcinoma: prevalence, severity, correlates, management, and relation to quality of life. Cancer 82(9): 1682–91

    Article  PubMed  CAS  Google Scholar 

  20. Smith IE, Dowsett M, Ebbs SR, et al. (2005) Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial. J Clin Oncol 23(22): 5108–16

    Article  PubMed  CAS  Google Scholar 

  21. Howell A, Cuzick J, Baum M, et al. (2005) Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years’ adjuvant treatment for breast cancer. Lancet 365(9453): 60–2

    Article  PubMed  CAS  Google Scholar 

  22. Stevenson DW, Delprato DJ (1983) Multiple component self-control program for menopausal hot flashes. Behav Ther Exp Psychiatry 14(2): 137–40

    Article  CAS  Google Scholar 

  23. Freedman RR (1998) Biochemical, metabolic, and vascular mechanisms in menopausal hot flashes. Fertil Steril 70(2): 332–7

    Article  PubMed  CAS  Google Scholar 

  24. Goldberg RM, Loprinzi CL, O’Fallon JR, et al. (1994) Transdermal clonidine for ameliorating tamoxifen-induced hot flashes. J Clin Oncol 12(1): 155–8

    PubMed  CAS  Google Scholar 

  25. Loprinzi CL, Michalak JC, Quella SK, et al. (1994) Megestrol acetate for the prevention of hot flashes. N Engl J Med 331(6): 347–52

    Article  PubMed  CAS  Google Scholar 

  26. Loprinzi CL, Pisansky TM, Fonseca R, et al. (1998) Pilot evaluation of venlafaxine hydrochloride for the therapy of hot flashes in cancer survivors. J Clin Oncol 16(7): 2377–81

    PubMed  CAS  Google Scholar 

  27. Loprinzi CL, Kugler JW, Sloan JA, et al. (2000) Venlafaxine in management of hot flashes in survivors of breast cancer: a randomised controlled trial. Lancet 356(9247): 2059–63

    Article  PubMed  CAS  Google Scholar 

  28. Guttuso T Jr, Kurlan R, McDermott MP, et al. (2003) Gabapentin’s effects on hot flashes in postmenopausal women: a randomized controlled trial. Obstet Gynecol 101(2): 337–45

    Article  PubMed  CAS  Google Scholar 

  29. Pandya KJ, Morrow GR, Roscoe JA (2005) Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial. Lancet 366(9488): 818–24

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  30. Sloan JA, Loprinzi CL, Novotny PJ, et al. (2001) Methodologic lessons learned from hot flash studies. J Clin Oncol 19(23): 4280–90

    PubMed  CAS  Google Scholar 

  31. Zierau O, Bodinet C, Kolba S, et al. (2002) Antiestrogenic activities of Cimicifuga racemosa extracts. J Steroid Biochem Mol Biol 80(1): 125–30

    Article  PubMed  CAS  Google Scholar 

  32. Huntley A, Ernst E (2003) A systematic review of the safety of black cohosh. Menopause 10(1): 58–64

    PubMed  Google Scholar 

  33. Bodinet C, Freudenstein J (2004) Influence of marketed herbal menopause preparations on MCF-7 cell proliferation. Menopause 11(3): 281–9

    Article  PubMed  Google Scholar 

  34. Mahady GB (2005) Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms. Treat Endocrinol 4(3): 177–84

    Article  PubMed  Google Scholar 

  35. Einbond LS, Shimizu M, Xiao D, et al. (2004) Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells. Breast Cancer Res Treat 83(3): 221–31

    Article  PubMed  CAS  Google Scholar 

  36. Hostanska K, Nisslein T, Freudenstein J, et al. (2004) Cimicifuga racemosa extract inhibits proliferation of estrogen receptor-positive and negative human breast carcinoma cell lines by induction of apoptosis. Breast Cancer Res Treat 84(2): 151–60

    Article  PubMed  CAS  Google Scholar 

  37. Freudenstein J, Dasenbrock C, Nisslein T (2002) Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extract. Cancer Res 62(12): 3448–52

    PubMed  CAS  Google Scholar 

  38. Lupu R, Mehmi I, Atlas E, et al. (2003) Black cohosh, a menopausal remedy, does not have estrogenic activity and does not promote breast cancer cell growth. Int J Oncol 23(5): 1407–12

    PubMed  CAS  Google Scholar 

  39. Hernández Muñoz G, Pluchino S (2003) Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer. Maturitas 44 Suppl 1: S59–65

    Article  Google Scholar 

  40. Pockaj BA, Loprinzi CL, Sloan JA, et al. (2004) Pilot evaluation of black cohosh for the treatment of hot flashes in women. Cancer Invest 22(4): 515–21

    Article  PubMed  Google Scholar 

  41. Jacobson JS, Troxel AB, Evans J, et al. (2001) Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol 19(10): 2739–45

    PubMed  CAS  Google Scholar 

  42. Borrelli F, Ernst E (2002) Cimicifuga racemosa: a systematic review of its clinical efficacy. Eur J Clin Pharmacol 58(4): 235–41

    Article  PubMed  Google Scholar 

  43. Cohen SM, O’Connor AM, Hart J et al. (2004) Autoimmune hepatitis associated with the use of black cohosh: a case study. Menopause 11(5): 575–7

    Article  PubMed  Google Scholar 

  44. Harris DM, Besselink E, Henning SM, et al. (2005) Phytoestrogens induce differential estrogen receptor alpha-or Beta-mediated responses in transfected breast cancer cells. Exp Biol Med (Maywood) 230(8): 558–68

    CAS  Google Scholar 

  45. Albertazzi P, Pansini F, Bonaccorsi G, et al. (1998) The effect of dietary soy supplementation on hot flushes. Obstet Gynecol 91(1): 6–11

    Article  PubMed  CAS  Google Scholar 

  46. Upmalis DH, Lobo R, Bradley L, et al. (2000) Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study. Menopause 7(4): 236–42

    Article  PubMed  CAS  Google Scholar 

  47. Quella SK, Loprinzi CL, Barton DL, et al. (2000) Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: A North Central Cancer Treatment Group Trial. J Clin Oncol 18(5): 1068–74

    PubMed  CAS  Google Scholar 

  48. Van Patten CL, Olivotto IA, Chambers GK, et al. (2002) Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial. J Clin Oncol 20(6): 1449–55.

    Article  PubMed  Google Scholar 

  49. Tice JA, Ettinger B, Ensrud K, et al. (2003) Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. JAMA 290(2): 207–14

    Article  PubMed  CAS  Google Scholar 

  50. Penotti M, Fabio E, Modena AB, et al. (2003) Effect of soy-derived isoflavones on hot flushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries. Fertil Steril 79(5): 1112–7

    Article  PubMed  Google Scholar 

  51. MacGregor CA, Canney PA, Patterson G, et al. (2005) A randomised double-blind controlled trial of oral soy supplements versus placebo for treatment of menopausal symptoms in patients with early breast cancer. Eur J Cancer 41(5): 708–14

    Article  PubMed  CAS  Google Scholar 

  52. Peeters PH, Keinan-Boker L, van der Schouw YT, et al. (2003) Phytoestrogens and breast cancer risk. Review of the epidemiological evidence. Breast Cancer Res Treat 77(2): 171–83

    Article  PubMed  CAS  Google Scholar 

  53. Jacobs J, Herman P, Heron K, et al. (2005) Homeopathy for menopausal symptoms in breast cancer survivors: a preliminary randomized controlled trial. J Altern Complement Med 11(1): 21–7

    Article  PubMed  Google Scholar 

  54. Thompson EA, Reilly D (2003) The homeopathic approach to the treatment of symptoms of oestrogen withdrawal in breast cancer patients A prospective observational study. Homeopathy 92(3): 131–4

    Article  PubMed  CAS  Google Scholar 

  55. Barton DL, Loprinzi CL, Quella SK, et al. (1998) Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. J Clin Oncol 16(2): 495–500

    PubMed  CAS  Google Scholar 

  56. Wyon Y, Wijma K, Nedstrand E, et al. (2004) A comparison of acupuncture and oral estradiol treatment of vasomotor symptoms in postmenopausal women. Climacteric 7(2): 153–64

    Article  PubMed  CAS  Google Scholar 

  57. Nedstrand E, Wijma K, Wyon Y, et al. (2005) Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study. Climacteric 8(3): 243–50

    Article  PubMed  CAS  Google Scholar 

  58. Ganz PA, Greendale GA, Petersen L, et al. (2000) Managing menopausal symptoms in breast cancer survivors: results of a randomized controlled trial. J Natl Cancer Inst 92(13): 1054–64

    Article  PubMed  CAS  Google Scholar 

  59. Freedman RR, Woodward S (1992) Behavioral treatment of menopausal hot flushes: evaluation by ambulatory monitoring. Am J Obstet Gynecol 167(2): 436–9

    Article  PubMed  CAS  Google Scholar 

  60. Ueda M (2004) A 12-week structured education and exercise program improved climacteric symptoms in middle-aged women. J Physiol Anthropol Appl Human Sci 23(5): 143–8

    Article  PubMed  Google Scholar 

  61. Lindh-Astrand L, Nedstrand E, Wyon Y, et al. (2004) Vasomotor symptoms and quality of life in previously sedentary postmenopausal women randomised to physical activity or estrogen therapy. Maturitas 48(2): 97–105

    Article  PubMed  CAS  Google Scholar 

  62. Irvin JH, Domar AD, Clark C, et al. (1996) The effects of relaxation response training on menopausal symptoms. J Psychosom Obstet Gynaecol 17(4): 202–7

    Article  PubMed  CAS  Google Scholar 

  63. Bertelli G, Venturini M, Del Mastro L, et al. (2002) Intramuscular depot medroxyprogesterone versus oral megestrol for the control of postmenopausal hot flashes in breast cancer patients: a randomized study. Ann Oncol 13(6): 883–8

    Article  PubMed  CAS  Google Scholar 

  64. Bullock JL, Massey FM, Gambrell RD Jr (1975) Use of medroxyprogesterone acetate to prevent menopausal symptoms. Obstet Gynecol 46(2): 165–8

    PubMed  CAS  Google Scholar 

  65. Schiff I, Tulchinsky D, Cramer D, et al. (1980) Oral medroxyprogesterone in the treatment of postmenopausal symptoms. JAMA 244(13): 1443–5

    Article  PubMed  CAS  Google Scholar 

  66. Morrison JC, Martin DC, Blair RA, et al. (1980) The use of medroxyprogesterone acetate for relief of climacteric symptoms. Am J Obstet Gynecol 138(1): 99–104

    PubMed  CAS  Google Scholar 

  67. Quella SK, Loprinzi CL, Sloan JA, et al. (1998) Long term use of megestrol acetate by cancer survivors for the treatment of hot flashes. Cancer 82(9): 1784–8

    Article  PubMed  CAS  Google Scholar 

  68. Leonetti HB, Longo S, Anasti JN (1999) Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss. Obstet Gynecol 94(2): 225–8

    Article  PubMed  CAS  Google Scholar 

  69. Ross RK, Paganini-Hill A, Wan PC, et al. (2000) Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin. J Natl Cancer Inst 92(4): 328–32

    Article  PubMed  CAS  Google Scholar 

  70. von Schoultz E, Rutqvist LE (2005) Menopausal hormone therapy after breast cancer: the Stockholm randomized trial. J Natl Cancer Inst 97(7): 533–5

    Article  Google Scholar 

  71. Nagamani M, Kelver ME, Smith ER (1987) Treatment of menopausal hot flashes with transdermal administration of clonidine. Am J Obstet Gynecol 156(3): 561–5

    Article  PubMed  CAS  Google Scholar 

  72. Pandya KJ, Raubertas RF, Flynn PJ, et al. (2000) Oral clonidine in postmenopausal patients with breast cancer experiencing tamoxifen-induced hot flashes: a University of Rochester Cancer Center Community Clinical Oncology Program study. Ann Intern Med 132(10): 788–93

    Article  PubMed  CAS  Google Scholar 

  73. Clayden JR, Bell JW, Pollard P (1974) Menopausal flushing: double-blind trial of a non-hormonal medication. Br Med J 1(5905): 409–12

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  74. Laufer LR, Erlik Y, Meldrum DR, et al. (1982) Effect of clonidine on hot flashes in postmenopausal women. Obstet Gynecol 60(5): 583–6

    PubMed  CAS  Google Scholar 

  75. Loprinzi L, Barton DL, Sloan JA, et al. (2002) Pilot evaluation of gabapentin for treating hot flashes. Mayo Clin Proc 77(11): 1159–63

    Article  PubMed  CAS  Google Scholar 

  76. Pandya KJ, Thummala AR, Griggs JJ, et al. (2004) Pilot study using gabapentin for tamoxifen-induced hot flashes in women with breast cancer. Breast Cancer Res Treat 83(1): 87–9

    Article  PubMed  CAS  Google Scholar 

  77. Quella SK, Loprinzi CL, Sloan J, et al. (1999) Pilot evaluation of venlafaxine for the treatment of hot flashes in men undergoing androgen ablation therapy for prostate cancer. J Urol 162(1): 98–102

    PubMed  CAS  Google Scholar 

  78. Barton D, La VB, Loprinzi C, et al. (2002) Venlafaxine for the control of hot flashes: results of a longitudinal continuation study. Oncol Nurs Forum 29(1): 33–40

    Article  PubMed  Google Scholar 

  79. Evans ML, Pritts E, Vittinghoff E, et al. (2005) Management of postmenopausal hot flushes with venlafaxine hydrochloride: a randomized, controlled trial. Obstet Gynecol 105(1): 161–6

    Article  PubMed  CAS  Google Scholar 

  80. Gregorian RS, Golden KA, Bahce A, et al. (2002) Antidepressant-induced sexual dysfunction. Ann Pharmacother 36(10): 1577–89

    Article  PubMed  CAS  Google Scholar 

  81. Loprinzi CL, Sloan JA, Perez EA, et al. (2002) Phase III evaluation of fluoxetine for treatment of hot flashes. J Clin Oncol 20(6): 1578–83

    Article  PubMed  CAS  Google Scholar 

  82. Stearns V, Beebe KL, Iyengar M, et al. (2003) Paroxetine controlled release in the treatment of menopausal hot flashes: a randomized controlled trial. JAMA 289(21): 2827–34.

    Article  PubMed  CAS  Google Scholar 

  83. Stearns V, Slack R, Greep N, et al. (2005) Paroxetine is an effective treatment for hot flashes: results from a prospective randomized clinical trial. J Clin Oncol 23(28): 6919–30

    Article  PubMed  CAS  Google Scholar 

  84. Stearns V, Johnson MD, Rae JM, et al. (2003) Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst 95(23): 1758–64

    Article  PubMed  CAS  Google Scholar 

  85. Jin Y, Desta Z, Stearns V et al. (2005) CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst 97(1): 30–9

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Groupe hospitalier Diaconesses, Croix Saint-Simon, 18, rue du Sergent-Bauchat, 75012, Paris

    Anne Plantade

Authors
  1. Anne Plantade
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag France

About this chapter

Cite this chapter

Plantade, A. (2010). Bouffées de chaleur. In: Aider á vivre aprés un cancer. Oncologie pratique. Springer, Paris. https://doi.org/10.1007/978-2-287-79501-5_4

Download citation

  • DOI: https://doi.org/10.1007/978-2-287-79501-5_4

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-287-79500-8

  • Online ISBN: 978-2-287-79501-5

Publish with us

Policies and ethics

Search

Navigation