Résumé
Les traitements modernes du cancer du sein ont permis une amélioration de la survie á long terme. La chimiothérapie adjuvante et/ou les nouvelles molécules de traitements ciblés ont permis de prolonger la survie sans récidive et la survie globale (1). La radiothérapie adjuvante joue un rôle essentiel dans la prévention des récidives locorégionales du cancer du sein et son effi cacité a été démontrée dans plusieurs essais randomisés, ainsi que dans la méta-analyse (2–9). Dans les formes á haut risque de récidive, cette action locorégionale de la radiothérapie se traduit par un bénéfi ce de survie á long terme (9). Plusieurs techniques d’irradiation de plus en plus améliorées ont été développées (10–13) pour diminuer la toxicité á court et á long terme (14–18). L’hormonothérapie joue également un rôle important dans le traitement de patients présentant des récepteurs á oestrogéne et progestérone positifs (19). L’ensemble de ces traitements est indispensable pour la prise en charge de patientes avec un cancer du sein, mais il peut être responsable de complications á long terme de type tumeurs secondaires. La cancérogenése est multifactorielle: la prédisposition génétique, la chimiothérapie, la radiothérapie, l’hormonothérapie sont connues pour être des facteurs de risque de cancer (14).
This is a preview of subscription content, log in via an institution.
Preview
Unable to display preview. Download preview PDF.
’Références
Smith I, Procter M, Gelber RD, et al. (2007) 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 369: 29–36
Fisher B, Anderson S, Bryant J, et al. (2002) Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347: 1233–41
Clark R, McCullock P, Levine M, et al. (1992) Randomized clinical trial to assess the effectiveness of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer. J Natl Cancer Inst 84: 683–9
VanDongen JA, Voogd AC, Fentiman IS, et al. (2000) Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: EORTC 10801 trial. J Natl Cancer Inst 92: 1143–50
Veronesi U, Cascinelli N, Mariani L, et al. (2002) Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 347: 1227–32
Jacobson JA, Danforth DN, Cowan KH, et al. (1995) Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med 332: 907–11
Blichert-Toft M, Roce C, Anderson JA, et al. (1992) Danish randomized trial comparing breast conservation therapy with mastectomy: Six years of life table analysis. Danish Breast Cancer Cooperative group. J Natl Cancer Inst Monograms 11: 19–25
Arriagada R, Le MG, Guinebretiére JM, et al. (2003) Late local recurrences in a randomised trial comparing conservative treatment with total mastectomy in early breast cancer patients. Ann Oncol 14: 1617–22
Early Breast Cancer Trialists’ Collaborative Group (2000) Favorable and unfavorable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomized trials. Lancet 355: 1757–70
Campana F, Kirova YM, Rosenwald JC, et al. (2005) Breast radiotherapy in the lateral decubitus position — a technique to prevent lung and heart irradiation. Int J Radiat Oncol Biol Phys 61(5): 1348–54
Kirova Y, Servois V, Campana F, et al. (2006) CT-scan based localization of the internal mammary chain and supra clavicular nodes for breast cancer radiation therapy planning. Radiother Oncol 79: 310–5
Grann A, McCormic B, Chabner ES, et al. (2000) Prone breast radiotherapy in earlystage breast cancer: a preliminary analysis. Int J Radiat Oncol Biol Phys 47: 319–25
Kirova YM, Campana F, Fournier-Bidoz N, et al. (2007) Postmastectomy electron beam chest wall irradiation in women with breast cancer: a clinical step towards conformal electron therapy. Int J Radiat Oncol Biol Phys 69: 1137–44
Kirova YM, De Rycke Y, Gambotti L, et al. (2008) Second malignancies after breast cancer: the impact of different treatment modalities. Br J Cancer 98: 870–4
Campana F, Kirova YM, Zervoudis S, et al. (2007) Postmastectomy electron-beam chest wall irradiation in women with breast cancer: early and late complications. Gyneco Ro 3: 170–3
Kirova YM, Gambotti L, De Rycke Y, et al. (2007) Risk of second malignancies (SM) following adjuvant radiotherapy (RT) for breast cancer (BC): a large scale single institution review. Int J Radiat Oncol Biol Phys 68: 359–63
Kirova Y, Vilcoq JR, Asselain B, et al. (2005) Radiation-induced sarcomas (RIS) following radiotherapy for breast cancer: a large-scale single institution review. Cancer 104: 856–63
Kirova YM, Feuilhade F, Calitchi E, et al. (1998) Radiation-induced sarcomas following radiotherapy for breast cancer: six case reports and a review of the literature. Breast 7: 277–82
Arimidex, Tamoxifen, Alone or in Combination (ATAC) Trialist’ Group et al. (2008) Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol 9: 45–53
Campone M, Roché H, Kerbrat P, et al. (2005) Secondary leukemia after epirubicin-based adjuvant chemotherapy in operable breast cancer patients: 16 years experience of the French Adjuvant Study Group. Ann Oncol 16: 1343–51
Beck A (1922) Zur Frage des Rontgenosarcomas Zugleich ein Beitrag zur Pathogenese des Sarcomas. Munch Med Wochenschr 69: 623–5
Brenin CM, Small W, Talamonti MS, Gradishar WJ (2002) Radiation-induced sarcoma following treatment of breast cancer. Cancer control 5: 425–32
De Vathaire F, Shamsaldin A, Grimaud E, Campbell S, et al. (1995) Solid malignant neoplasms after childhood irradiation: decrease of the relative risk with time after irradiation. C R Acad Paris 318: 483–90
Kirova Y, Rafi H, Voisin MC, et al. (2000) Radiation-induced bone sarcoma following total body irradiation: role of additional radiation on localized areas. Bone Marrow Transplantation 25: 1011–3
Warren S, Sommer GN (1936) Fibrosarcoma of the soft parts with special reference to recurrence and metastasis. Arch Surg 33: 425–50
Cahan WG, Woodward HQ, Higinbothan NL, et al. (1948) Sarcoma arising in irradiated bone: report of eleven cases. Cancer 1: 3–29
Taghian A, de Vathaire F, Terrier P, et al. (1991) Long-term risk of sarcoma following radiation treatment for breast cancer. Int J Radiat Oncol Biol Phys 21: 361–7
Yap J, Chuba PJ, Thomas R, et al. (2002) Sarcoma as a second malignancy after treatment for breast cancer. Int J Radiat Oncol Biol Phys 52: 1231–7
Huang J, Mackillop WJ (2001) Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma. Cancer 82: 172–80
Karlsson P, Holmberg E, Samuelsson A, et al. (1998) Soft tissue sarcoma after treatment for breast cancer-a Swedish population — based study. Eur J Cancer 34: 2068–75
Cozen W, Bernstein L, Wang F, et al. (1999) The risk of angiosarcoma following primary breast cancer. BJC 81: 532–6
Marchal C, Weber B, de Lafontan B, et al. (1999) Nine breast angiosarcomas after conservative treatment for breast carcinoma: a survey from French Comprehensive Cancer Centers. Int J Radiat Oncol Biol Phys 44: 113–9
Zukali R, Merson M, Placuci M, et al. (1994) Soft tissue sarcoma of the breast after conservative surgery and irradiation for early mammary cancer. Radiother Oncol 30: 271–3
Doherty MA, Rodger A, Langlands AO (1986) Sarcoma of bone following therapeutic irradiation for breast carcinoma. Int J Radiat Oncol Biol Phys 12: 103–6
Pierce SM, Recht A, Lingos T (1992) Long term radiation complications following conservative surgery and radiation therapy in patients with early stage breast cancer. Int J Radiat Oncol Biol Phys 23: 915–23
Rao J, DeKoven JG, David Beatty J, Jones G (2003) Cutaneous angiosarcoma as a delayed complication of radiation therapy for carcinoma of the breast. J Am Acad Dermatol 49: 532–8
Karlsson P, Holmberg E, Johansson KA, et al. (1996) Soft tissue sarcoma after treatment for breast cancer. Radiother Oncol 38: 25–31
Stokkel MPM, Peterse HL (1995) Angiosarcoma of the breast after lumpectomy and radiation therapy for adenocarcinoma. Cancer 6: 2965–8
Mills TD, Vinnicombe SJ, Wells CA, et al. (2001) Angiosarcoma of the breast after wide local excision and radiotherapy for breast carcinoma. Clin Radiol 57: 63–74
Wijnmaalen A, van Ooijen B, van Geel BN, et al. (1993) Angiosarcoma of the breast following lumpectomy, axillary lymph node dissection, and radiotherapy for primary breast cancer: 3 case reports and a review of the literature. Int J Radiat Oncol Biol Phys 2: 135–9
ICRU Report 50 et ICRU Report 62 (Supplement to ICRU Report 50): Prescribing, Recording and Reporting Photon Beam Therapy, Issued 1999, Bethesda, Maryland, USA
Kaplan EL, Meier P (1958) Non-parametric estimation from incomplete observations. J Am Stat Assoc 53: 457–81
Breslow NE, Day NE (1980) Statistical methods in cancer research. Volume I: The analysis of case control studies. IARC Scientific Publications no32, Lyon
Remontet L, Buemi A, Velten M, et al. (2003) Évolution de l’incidence et de la mortalité par cancer en France de 1978 á 2000. Rev Épidémiol Santé Publique 51 (1 pt 1): 3–30
Stout AP, Lattres R (1967) Tumors of the soft tissues. Atlas of tumor Pathology, 2nd series. Armed Forces institute of Pathology, Washington DC
Sheppard DG, Libshitz HI (2001) Post-radiation sarcomas: a review of the clinical and imaging feature in 63 cases. Clin Radiol 56: 22–29
Valagussa P, Tancini G, Bonadonna G (1987) Second malignancies after CMF for respectable breast cancer. J Clin Oncol 5: 1138–42
Dowd SB (1994) The practice of radiologic sciences. Radiol Technol 66: 32–3
Tubiana M (1983) Cancers par nuisance thérapeutiques: cancers et radiothérapie. Bull Cancer 70: 47–54
Maruyama T, Kumamoto Y, Noda Y (1988) Reassessment of gamma doses from atomic bombs in Hiroshima and Nagasaki. Radiat Res 113: 1–14
Ishimaru M, Ishimaru T (1975) A review of 30 years study of Hiroshima and Nagasaki atomic bomb survivors. Biological effects. Leukemia and Related Disorders. J Radiat Res 16: S89–96
Hardy TJ, An T, Brown P, Terz JJ (1978) Postirradiation sarcoma (malignant fibrous histiocytoma) of axilla. Cancer 4: 118–24
Rosen PP, Kimmel M, Ernsberger D (1988) Mammary angiosarcoma-the prognostic significance of tumor differentiation. Cancer 62: 2145–51
Wiklund TA, Blomqvist CP, Raty J, et al. (1991) Postirradiation sarcoma: analysis of a nation wide cancer registry material. Cancer 68: 524–31
Laskin WB, Silverman TA, Enzinger FM (1988) Postirradiation soft tissue sarcomas: an analysis of 53 cases. Cancer 62: 2330–40
Kim JH, Chu FCH, Woodward HQ, Huvos A (1983) Radiation induced sarcomas of bone following therapeutic radiation. Int J Radiat Oncol Biol Phys 9:107–10
Kuten A, Sapir D, Cohen Y, et al. (1985) Postirradiation soft tissue sarcoma occurring in breast cancer patients: report of seven cases and results of combination chemotherapy. J Surg Oncol 28: 168–71
Robinson E, Neugut A, Wylie P (1988) Review: clinical aspects of postirradiation sarcomas. J Nat Cancer Inst 80: 233–41
Références
Madelaine I (2008) Seconds Cancers. In: Dossier du CNIMH XXIX: 146
Hershman D, Neugut AI, Jacobson JS, et al. (2007) Acute myeloid leukaemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy. J Natl Cancer Inst 99: 196–205
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag France
About this chapter
Cite this chapter
Kirova, Y.M. (2010). Tumeurs secondaires: l’expérience du cancer du sein. In: Aider á vivre aprés un cancer. Oncologie pratique. Springer, Paris. https://doi.org/10.1007/978-2-287-79501-5_15
Download citation
DOI: https://doi.org/10.1007/978-2-287-79501-5_15
Publisher Name: Springer, Paris
Print ISBN: 978-2-287-79500-8
Online ISBN: 978-2-287-79501-5