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Le rétinoblastome: Le modèle de la prédisposition génétique

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Épidémiologie des cancers de l’enfant
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Abstrait

Le rêtinoblastome est une tumeur maligne embryonnaire de l’enfant développée aux dépens des cônes rétiniens; son incidence est de 1 pour 15 000 à 20 000 naissances. Dans 90 % des cas, le diagnostic est effectué avant l’âge de 3 ans.

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Références

  1. Knudson AG (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Nat Acad Sci 68: 820–3

    Article  PubMed  Google Scholar 

  2. Comings DE (1973) A general theory of carcinogenesis. Proc Natl Acad Sci USA 70: 3324–8

    Article  PubMed  CAS  Google Scholar 

  3. Baud O, Cormier-Daire V, Lyonnet S et al. (1999) Dysmorphic phenotype and neurological impairment in 22 retinoblastoma patients with constitutional cytogenetic 13q deletion. Clin Genet 55: 478–82

    Article  PubMed  CAS  Google Scholar 

  4. Friend SH, Bernards R, Rogelj S et al. (1986) A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323: 643–6

    Article  PubMed  CAS  Google Scholar 

  5. Houdayer C, Gauthier-Villars M, Laugé A et al. (2004) Comprehensive screening for constitutional RBI mutations by DHPLC and QMPSE Hum Mutat 23: 193–202

    Article  PubMed  CAS  Google Scholar 

  6. Taylor M, Dehainault C, Desjardins L et al. (2007) Genotype-phenotype correlations in hereditary familial retinoblastoma. Hum Mutat 28: 284–93

    Article  PubMed  Google Scholar 

  7. Draper GJ, Sanders BM, Kingston JE (1986) Second primary neoplasms in patients with retinoblastoma. Br J Cancer 53: 661–71

    PubMed  CAS  Google Scholar 

  8. Fletcher O, Easton D, Anderson K et al. (2004) Lifetime risks of common cancers among retinoblastoma survivors. J Natl Cancer Inst 96: 357–63

    Article  PubMed  Google Scholar 

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© 2009 Springer-Verlag France

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Gauthier-Villars, M. (2009). Le rétinoblastome: Le modèle de la prédisposition génétique. In: Épidémiologie des cancers de l’enfant. Springer, Paris. https://doi.org/10.1007/978-2-287-78337-1_14

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  • DOI: https://doi.org/10.1007/978-2-287-78337-1_14

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-287-78336-4

  • Online ISBN: 978-2-287-78337-1

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