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Prise en charge des patientes exposées in utero au DES, l’expérience de Port-Royal

  • J. -C. Pons
  • A. Billon
  • M. Hessabi
  • M. Duyme
  • E. Papiernik-Berkhauer

Abstrait

Les travaux réalisés à la maternité de Port-Royal à Paris portent sur deux aspects du DES-syndrome:
  • la prévention de la prématurité en deuxième génération;

  • la fréquence de l’hypospadias en troisième génération.

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Références

  1. 1.
    Mangan CE, Burnett-Rubin MM, Egan V et al. (1982) Pregnancy outcome in 98 women exposed to diethylstilbestrol in utero, their mothers, and unexposed sibling. Obstet Gynecol 59: 315–9PubMedGoogle Scholar
  2. 2.
    Klip H, Verloop J, D van Gool J et al. (2002) Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study. Lancet 359: 1102–7PubMedCrossRefGoogle Scholar
  3. 3.
    Epelboin S. Communication personnelleGoogle Scholar
  4. 4.
    Brouwers MM, Feitz WF, Roelofs LA et al. (2006) Hypospadias: a transgenerational effect of diethylstilbestrol? Hum Reprod 21: 666–9PubMedCrossRefGoogle Scholar
  5. 5.
    Palmer JR, Wise LA, Robboy SJ et al. (2005) Hypospadias in sons of women exposed to diethyistilbestrol in utero. Epidemiology 16: 583–6PubMedCrossRefGoogle Scholar
  6. 6.
    Newbold RR, Hanson RB, Jefferson WN et al. (1998) Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis 19: 1655–63PubMedCrossRefGoogle Scholar
  7. 7.
    Newbold RR, Hanson RB, Jefferson WN et al. (2000) Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis 21: 1355–63PubMedCrossRefGoogle Scholar
  8. 8.
    Kaufman RH, Adam E (2002) Findings in female offspring of women exposed in utero to diethylstilbestrol. Obstet Gynecol 99: 197–200PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag France, Paris 2007

Authors and Affiliations

  • J. -C. Pons
    • 1
  • A. Billon
    • 2
  • M. Hessabi
    • 3
  • M. Duyme
    • 4
  • E. Papiernik-Berkhauer
    • 3
  1. 1.Service de gynécologie-obstétriqueCHU MichallonGrenoble Cedex 09
  2. 2.Département d’obstétrique, gynécologie et médecine de la reproductionUniversité Joseph Fourier CHU de GrenobleGrenoble
  3. 3.Service de gynécologie-obstétriqueUniversité René Descartes Maternité de Port-RoyalParis
  4. 4.Directeur de rechercheCNRS, Sciences de la vieMontpellier

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