Skip to main content
SpringerLink
Log in

Tumeurs stromales de l’ovaire

  • Chapter
Tumeurs malignes rares

  • 62 Accesses

Résumé

Approximativement 8 % des tumeurs ovariennes dérivent du stroma et/ou des cordons sexuels. Ces tumeurs sont généralement fonctionnelles puisque la plupart peuvent synthétiser des hormones (oestrogènes, androgènes, corticoïdes). Leur pronostic est difficile à établir, certaines étant de comportement presque toujours bénin (tumeurs à cellules de Sertoli, tumeurs à cellules de Leydig), d’autres de comportement malin mais avec des récidives locorégionales plus ou moins tardives. Les critères histologiques d’agressivité sont mal connus de telle sorte qu’il est difficile de proposer une classification anatomopathologique dichotomique bénin/malin et s’il n’y a pas de critères cliniques de «malignité», ces tumeurs sont classées comme étant de pronostic incertain. Dans ce groupe de tumeurs, celles qui auraient plutôt un comportement «malin» sont les suivantes: les tumeurs de la granulosa, les androblastomes (ou tumeurs de Sertoli-Leydig), les tumeurs des cordons sexuels avec tubules annelés, les tumeurs à cellules stéroïdiennes sans autre précision et les fibrosarcomes (1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. Young RH, Dudley AG, Scully RE (1984) Granulosa cell, Sertoli-Leydig cell, and unclassified sex cord-stromal tumors associated with pregnancy: a clinicopathological analysis of thirty-six cases. Gynecol Oncol 18: 181–205

    Article  CAS  PubMed  Google Scholar 

  2. Segal R, Depetrillo AD, Thomas G (1995) Clinical review of adult granulosa cell tumors of the ovary. Gynecol Oncol 56: 338–44

    Article  CAS  PubMed  Google Scholar 

  3. Dempster J, Geirsson RT, Duncan ID (1987) Survival after ovarian granulosa and theca cell tumours. Scott Med J 32: 38–9

    CAS  PubMed  Google Scholar 

  4. Garcia AA, Morrow CP (1999) Stromal tumors of the ovary. In: Raghavan D, Brecher M, Johnson DH, et al.. Textbook of uncommon cancer (2nd ed.), John Wiley & Sons, 661–9

    Google Scholar 

  5. Miller BE, Barron BA, Wan JY, et al. (1997) Prognostic factors in adult granulosa cell tumor of the ovary. Cancer 79: 1951–5

    Article  CAS  PubMed  Google Scholar 

  6. Hitchcock CL, Norris HJ, Khalifa MA, Wargotz ES (1989) Flow cytometric analysis of granulosa tumors. Cancer 64: 2127–32

    Article  CAS  PubMed  Google Scholar 

  7. Suh KS, Silverberg SG, Rhame JG, Wilkinson DS (1990) Granulosa cell tumor of the ovary. Histopathologic and flow cytometric analysis with clinical correlation. Arch Pathol Lab Med 114: 496–501

    CAS  PubMed  Google Scholar 

  8. King LA, Okagaki T, Gallup DG, et al. (1996) Mitotic count, nuclear atypia, and immunohistochemical determination of Ki-67, c-myc, p21-ras, c-erbB2, and p53 expression in granulosa cell tumors of the ovary: mitotic count and Ki-67 are indicators of poor prognosis. Gynecol Oncol 61: 227–32

    Article  CAS  PubMed  Google Scholar 

  9. Suh KS, Silverberg SG, Rhame JG, Wilkinson DS (1990) Granulosa cell tumor of the ovary. Histopathologic and flow cytometric analysis with clinical correlation. Arch Pathol Lab Med 114: 496–501

    CAS  PubMed  Google Scholar 

  10. Kaye SB, Davies E (1986) Cyclophosphamide, adriamycin, and cis-platinum for the treatment of advanced granu losa cell tumor, using serum estradiol as a tumor marker. Gynecol Oncol 24: 261–4

    Article  CAS  PubMed  Google Scholar 

  11. Healy DL, Burger HG, Mamers P, et al. (1993) Elevated serum inhibin concentrations in postmenopausal women with ovarian tumors. N Engl J Med 329: 1539–42

    Article  CAS  PubMed  Google Scholar 

  12. Segal R, Depetrillo AD, Thomas G (1995) Clinical review of adult granulosa cell tumors of the ovary. Gynecol Oncol 56: 338–44

    Article  CAS  PubMed  Google Scholar 

  13. Pankratz E, Boyes DA, White GW, et al. (1978) Granulosa cell tumors. A clinical review of 61 cases. Obstet Gynecol 52: 718–23

    CAS  PubMed  Google Scholar 

  14. Evans AT, Gaffey TA, Malkasian GDJ, Annegers JF (1980) Clinicopathologic review of 118 granulosa and 82 theca cell tumors. Obstet Gynecol 55: 231–8

    PubMed  Google Scholar 

  15. Ohel G, Kaneti H, Schenker JG (1983) Granulosa cell tumors in Israel: a study of 172 cases. Gynecol Oncol 15: 278–86

    Article  CAS  PubMed  Google Scholar 

  16. Jacobs AJ, Harris M, Deppe G, et al. (1982) Treatment of recurrent and persistent germ cell tumors with cisplatin, vinblastine, and bleomycin. Obstet Gynecol 59: 129–32

    CAS  PubMed  Google Scholar 

  17. Evans AT, Gaffey TA, Malkasian GDJ, Annegers JF (1980) Clinicopathologic review of 118 granulosa and 82 theca cell tumors. Obstet Gynecol 55: 231–8

    PubMed  Google Scholar 

  18. Ohel G, Kaneti H, Schenker JG (1983) Granulosa cell tumors in Israel: a study of 172 cases. Gynecol Oncol 15: 278–86

    Article  CAS  PubMed  Google Scholar 

  19. Colombo N, Sessa C, Landoni F, et al. (1986) Cisplatin, vinblastine, and bleomycin combination chemotherapy in metastatic granulosa cell tumor of the ovary. Obstet Gynecol 67: 265–8

    Article  CAS  PubMed  Google Scholar 

  20. Segal R, Depetrillo AD, Thomas G (1995) Clinical review of adult granulosa cell tumors of the ovary. Gynecol Oncol 56: 338–44

    Article  CAS  PubMed  Google Scholar 

  21. Calaminus G, Wessalowski R, Harms D, Gobel U (1997) Juvenile granulosa cell tumors of the ovary in children and adolescents: results from 33 patients registered in a prospective cooperative study. Gynecol Oncol 65: 447–52

    Article  CAS  PubMed  Google Scholar 

  22. Pankratz E, Boyes DA, White GW, et al. (1978) Granulosa cell tumors. A clinical review of 61 cases. Obstet Gynecol 52: 718–23

    CAS  PubMed  Google Scholar 

  23. Kaye SB, Davies E (1986) Cyclophosphamide, adriamycin, and cis-platinum for the treatment of advanced granulosa cell tumor, using serum estradiol as a tumor marker. Gynecol Oncol 24: 261–4

    Article  CAS  PubMed  Google Scholar 

  24. Lappohn RE, Burger HG, Bouma J, et al. (1989) Inhibin as a marker for granulosa-cell tumors [see comments]. N Engl J Med 321: 790–3

    Article  CAS  PubMed  Google Scholar 

  25. Evans AT, Gaffey TA, Malkasian GDJ, Annegers JF (1980) Clinicopathologic review of 118 granulosa and 82 theca cell tumors. Obstet Gynecol 55: 231–8

    PubMed  Google Scholar 

  26. Zaloudek C, Norris HJ (1984) Sertoli-Leydig tumors of the ovary. A clinicopathologic study of 64 intermediate and poorly differentiated neoplasms. Am J Surg Pathol 8: 405–18

    Article  CAS  PubMed  Google Scholar 

  27. Young RH, Scully RE (1985) Ovarian Sertoli-Leydig cell tumors. A clinicopathological analysis of 207 cases. Am J Surg. Pathol 9: 543–69

    Article  CAS  PubMed  Google Scholar 

  28. Young RH, Scully RE (1985) Ovarian Sertoli-Leydig cell tumors. A clinicopathological analysis of 207 cases. Am J Surg Pathol 9: 543–69

    Article  CAS  PubMed  Google Scholar 

  29. Zaloudek C, Norris HJ (1984) Sertoli-Leydig tumors of the ovary. A clinicopathologic study of 64 intermediate and poorly differentiated neoplasms. Am J Surg.Pathol 8: 405–18

    Article  CAS  PubMed  Google Scholar 

  30. Young RH, Scully RE (1985) Ovarian Sertoli-Leydig cell tumors. A clinicopathological analysis of 207 cases. Am J Surg.Pathol 9: 543–69

    Article  CAS  PubMed  Google Scholar 

  31. Young RH, Scully RE (1985) Ovarian Sertoli-Leydig cell tumors. A clinicopathological analysis of 207 cases. Am J Surg Pathol 9: 543–69

    Article  CAS  PubMed  Google Scholar 

  32. Prat J, Young RH, Scully RE (1982) Ovarian Sertoli-Leydig cell tumors with heterologous elements. II. Cartilage and skeletal muscle: a clinicopathologic analysis of twelve cases. Cancer 50: 2465–75

    Article  CAS  PubMed  Google Scholar 

  33. Kietlinska Z, Pietrzak K, Drabik M (1993) The management of granulosa-cell tumors of the ovary based on longterm follow up. Eur J Gynaecol.Oncol 14:118–27

    PubMed  Google Scholar 

  34. Zaloudek C, Norris HJ (1984) Sertoli-Leydig tumors of the ovary. A clinicopathologic study of 64 intermediate and poorly differentiated neoplasms. Am J Surg Pathol 8: 405–18

    Article  CAS  PubMed  Google Scholar 

  35. Chalvardjian A, Derzko C (1982) Gynandroblastoma: its ultrastructure. Cancer 50: 710–21

    Article  CAS  PubMed  Google Scholar 

  36. Novak ER (1967) Gynandroblastoma of the ovary: review of 8 cases from the ovarian tumor registry. Obstet Gynecol 30: 709–15

    CAS  PubMed  Google Scholar 

  37. Novak ER (1967) Gynandroblastoma of the ovary: review of 8 cases from the ovarian tumor registry. Obstet Gynecol 30: 709–15

    CAS  PubMed  Google Scholar 

  38. Hayes MC, Scully RE (1987) Ovarian steroid cell tumors (not otherwise specified). A clinicopathological analysis of 63 cases. Am J Surg Pathol 11: 835–45

    Article  CAS  PubMed  Google Scholar 

  39. Hayes MC, Scully RE (1987) Ovarian steroid cell tumors (not otherwise specified). A clinicopathological analysis of 63 cases. Am J Surg Pathol 11: 835–45

    Article  CAS  PubMed  Google Scholar 

  40. Taylor HB, Norris HJ (1967) Lipid cell tumors of the ovary. Cancer 20: 1953–62

    Article  CAS  PubMed  Google Scholar 

  41. Khoo SK, Buntine D (1980) Malignant stromal tumour of the ovary with virilizing effects in an XXX female with streak ovaries. Clinical and pathological studies. Aust N Z J Obstet Gynaecol 20: 123–8

    Article  CAS  PubMed  Google Scholar 

  42. Pankratz E, Boyes DA, White GW, et al. (1978) Granulosa cell tumors. A clinical review of 61 cases. Obstet Gynecol 52: 718–23

    CAS  PubMed  Google Scholar 

  43. Gershenson DM, Copeland LJ, Kavanagh JJ, et al. (1987) Treatment of metastatic stromal tumors of the ovary with cisplatin, doxorubicin, and cyclophosphamide. Obstet Gynecol 70: 765–9

    CAS  PubMed  Google Scholar 

  44. Gershenson DM, Copeland LJ, Kavanagh JJ, et al. (1987) Treatment of metastatic stromal tumors of the ovary with cisplatin, doxorubicin, and cyclophosphamide. Obstet Gynecol 70: 765–9

    CAS  PubMed  Google Scholar 

  45. Colombo N, Sessa C, Landoni F, et al. (1986) Cisplatin, vinblastine, and bleomycin combination chemotherapy in metastatic granulosa cell tumor of the ovary. Obstet Gynecol 67: 265–8

    Article  CAS  PubMed  Google Scholar 

  46. Zambetti M, Escobedo A, Pilotti S, De Palo G, et al. (1990) cis-platinum/vinblastine/bleomycin combination chemotherapy in advanced or recurrent granulosa cell tumors of the ovary. Gynecol Oncol 36: 317–20

    Article  CAS  PubMed  Google Scholar 

  47. Pectasides D, Alevizakos N, Athanassiou AE (1992) Cisplatin-containing regimen in advanced or recurrent granulosa cell tumours of the ovary. Ann Oncol 3: 316–8

    CAS  PubMed  Google Scholar 

  48. Fishman A, Kudelka AP, Tresukosol D, et al. (1996) Leuprolide acetate for treating refractory or persistent ovarian granulosa cell tumor. J Reprod Med 41: 393–6

    CAS  PubMed  Google Scholar 

  49. Malik ST, Slevin ML (1991) Medroxyprogesterone acetate (MPA) in advanced granulosa cell tumours of the ovary—a new therapeutic approach? [see comments]. Br J Cancer 63: 410–1

    Article  CAS  PubMed  Google Scholar 

  50. Motzer RJ, Geller NL, Tan CC, et al. (1991) Salvage chemotherapy for patients with germ cell tumors. The Memorial Sloan-Kettering Cancer Center experience (1979—1989). Cancer 67: 1305–10

    Article  CAS  PubMed  Google Scholar 

  51. Williams SD (1998) Ovarian germ cell tumors: an update. Semin Oncol 25: 407–13

    CAS  PubMed  Google Scholar 

  52. Mandanas RA, Saez RA, Epstein RB, et al. (1998) Longterm results of autologous marrow transplantation for relapsed or refractory male or female germ cell tumors. Bone Marrow Transplant 21: 569–76

    Article  CAS  PubMed  Google Scholar 

  53. Ray-Coquard I, Cassier P, Treilleux I, et al., and For the GINECO group France (2004) Ovarian Rare tumors. Impact of a French-speaking website on medical practice and inclusions in a clinical trial. Results after 1 year. Eur J Cancer

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Conticanet Network of Excellence FP6-018806, Université Claude-Bernard Lyon-I, 28, rue Laënnec, 69008, Lyon

    Isabelle Ray-Coquard

  2. Département de cancérologie médicale, Centre Léon-Bérard, 28, rue Laënnec, 69008, Lyon

    Isabelle Ray-Coquard

  3. Département d’oncologie médicale, Centre Léon-Bérard, 28, rue Laënnec, 69008, Lyon

    Jean Paul Guastalla

  4. Département d’anatomie pathologique, Centre Léon-Bérard, 28, rue Laenne, 69008, Lyon

    Isabelle Treilleux

Authors
  1. Isabelle Ray-Coquard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jean Paul Guastalla
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Isabelle Treilleux
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag France, Paris

About this chapter

Cite this chapter

Ray-Coquard, I., Guastalla, J.P., Treilleux, I. (2010). Tumeurs stromales de l’ovaire. In: Tumeurs malignes rares. Springer, Paris. https://doi.org/10.1007/978-2-287-72070-3_96

Download citation

  • DOI: https://doi.org/10.1007/978-2-287-72070-3_96

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-287-72069-7

  • Online ISBN: 978-2-287-72070-3

Publish with us

Policies and ethics

Search

Navigation