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Protection cérébrale: données expérimentales

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La réanimation neurochirurgicale

Part of the book series: Le point sur … ((POINT))

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Abstrait

Le concept de protection cérébrale fait référence à toute mesure pharmacologique ou non pharmacologique, qui, instaurée avant ou concomitamment à une agression hypoxique ou ischémique, entraîne une amélioration significative de la fonction neurologique. La protection cérébrale reste encore aujourd’hui un formidable défit. En effet, en ce début du troisième millénaire, les médecins confrontés aux patients à risque d’hypoxie ou d’ischémie s’interrogent toujours pour savoir dans quelle mesure cet objectif doit être considéré comme un rêve impossible ou une réalité naissante. Deux raisons essentielles sont à l’origine de cette étonnante perplexité. La première réside dans la connaissance de cette pathologie, qui est un préalable indispensable à l’instauration d’une thérapeutique efficace, préventive et curative. Or, l’ischémie cérébrale déclenche une cascade extrêmement complexe de réactions physiopathologiques et entraîne une multitude de réactions biochimiques, inflammatoires et géniques dont la finalité reste imparfaitement comprise. La seconde raison est liée au fait qu’une thérapeutique bénéfique au plan expérimental ne peut être transposée de manière systématique à une situation clinique. En d’autres termes, en dépit des avancées indéniables de la recherche fondamentale et de l’expérimentation animale, les mesures de protection cérébrale qui ont fait leur preuve en clinique humaine restent encore à ce jour très limitées.

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Authors and Affiliations

  1. Service Universitaire d’Anesthésie-Réanimation, CHR de la Citadelle, 4000, Liège, Belgique

    Pol Hans & Vincent Bonhomme

  2. Département d’Anesthésie-Réanimation, CHU de Liège, 4000, Liège, Belgique

    Colette Franssen

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  1. Pol Hans
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  3. Vincent Bonhomme
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Editors and Affiliations

  1. Département d’Anesthésie-Réanimation, CHU Timone, 264, rue Saint-Pierre, 13385, Marseille

    Nicolas Bruder

  2. Département d’Anesthésiologie et Réanimation, Hôpital Régional, Avenue du grand Champsec 80, CH-1951, Sion (Suisse)

    Patrick Ravussin

  3. Department of Anaesthesia, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8

    Bruno Bissonnette

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Hans, P., Franssen, C., Bonhomme, V. (2007). Protection cérébrale: données expérimentales. In: Bruder, N., Ravussin, P., Bissonnette, B. (eds) La réanimation neurochirurgicale. Le point sur …. Springer, Paris. https://doi.org/10.1007/978-2-287-68199-8_3

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