Skip to main content
SpringerLink
Log in

Facteurs de risque des cancers du sein familiaux

  • Chapter
Le cancer du sein

Part of the book series: Oncologie pratique ((ONCOLPRAT))

  • 543 Accesses

Abstrait

Le cancer du sein constitue une préoccupation majeure de santé publique en raison de ľaugmentation de son incidence., Ľhistoire familiale, attribuée à des facteurs génétiques similaires parmi les membres ďune même famille est ľun des facteurs de risque établis pour la maladie. Le risque de développer un cancer du sein est de deux à trois fois supérieur chez les femmes ayant un parent au premier degré (mère, sœur, fille) qui en est atteint. Pour les femmes avec un ou deux membres de la famille au premier degré atteints, le risque cumulé de cancer du sein jusqu’à ľâge de 80 ans s’élève respectivement à 13,3% ou 21,1%(1). Toutefois, les études épidémiologiques récentes montrent que, même si un risque majoré de cancer du sein est retrouvé chez les femmes qui ont des membres de la famille au premier degré atteints de la maladie, sur 9 femmes qui développent un cancer du sein, 8 n’ont pas de membres de la famille atteints du même cancer. Celles qui développeront le cancer du sein seront âgées de plus de 50 ans au moment du diagnostic (1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. Collaborative group on hormonal factors in breast cancer (2001) Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet 258: 1389–99

    Google Scholar 

  2. Wooster R, Weber BL (2003) Breast and ovarian cancer. N Engl J Med 348: 2339–47

    Article  PubMed  CAS  Google Scholar 

  3. de Jong MM, Nolte IM, te Meerman GJ et al. (2002) Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility. J Med Genet 39: 225–42

    Article  PubMed  Google Scholar 

  4. CHEK2 breast cancer case-control consortium (2004) CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies. Am J Hum Genet 74: 1175–82

    Article  Google Scholar 

  5. Antoniou A, Pharoah PD, Narod S et al. (2003) Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72: 1117–30

    Article  PubMed  CAS  Google Scholar 

  6. Garber JE, Goldstein AM, Kantor AF et al. (1991) Follow-up study of twenty-four families with Li-Fraumeni syndrome. Cancer Res 51: 6094–7

    PubMed  CAS  Google Scholar 

  7. Wolpert N, Warner E, Seminsky MF (2000) Prevalence of BRCA1 and BRCA2 mutations in male breast cancer patients in Canada. Clin Breast Cancer 1: 57–63

    Article  PubMed  CAS  Google Scholar 

  8. Kelsey JL, Bernstein L (1996) Epidemiology and prevention of breast cancer. Annu Rev Public Health 17: 47–67

    Article  PubMed  CAS  Google Scholar 

  9. Krainer M, Silva-Arrieta S, FitzGerald MG et al. (1997) Differential contributions of BRCA1 and BRCA2 to early-onset breast cancer. N Engl J Med 336: 1416–1421.

    Article  PubMed  CAS  Google Scholar 

  10. Collaborative group on hormonal factors in breast cancer (1997) Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Collaborative Group on Hormonal Factors in Breast Cancer. Lancet 350: 1047–59

    Article  Google Scholar 

  11. Malone KE, Daling JR, Thompson JD et al. (1998) BRCA1 mutations and breast cancer in the general population: analyses in women before age 35 years and in women before age 45 years with first-degree family history. J Am Med Assoc 279: 922–9

    Article  CAS  Google Scholar 

  12. Verhoog LC, Brekelmans CT, Seynaeve C et al. (2000) Contralateral breast cancer risk is influenced by the age at onset in BRCA1-associated breast cancer. Br J Cancer 83: 384–6

    Article  PubMed  CAS  Google Scholar 

  13. Ford D, Easton DF, Stratton M et al. (1998) Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am J Hum Genet 62: 676–89

    Article  PubMed  CAS  Google Scholar 

  14. Collaborative group on hormonal factors in breast cancer (1996) Breast cancer and hormonal contraceptives: further results. Collaborative Group on Hormonal Factors in Breast Cancer. Contraception 54: 1S–106S

    Article  Google Scholar 

  15. Narod SA, Dube MP, Klijn J et al. (2002) Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst 94: 1773–9

    PubMed  CAS  Google Scholar 

  16. Jernstrom H, Lerman C, Ghadirian P et al. (1999) Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2. Lancet 354: 1846–50

    Article  PubMed  CAS  Google Scholar 

  17. King MC, Wieand S, Hale K et al. (2001) Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial. JAMA 286: 2251–6

    Article  PubMed  CAS  Google Scholar 

  18. Powles TJ (2002) Anti-œstrogenic prevention of breast cancer-the make or break point. Nat Rev Cancer 2: 787–94

    Article  PubMed  CAS  Google Scholar 

  19. Metcalfe K, Lynch HT, Ghadirian P et al. (2004) Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. J Clin Oncol 22: 2328–35

    Article  PubMed  CAS  Google Scholar 

  20. Layde PM, Webster LA, Baughman AL et al. (1989) The independent associations of parity, age at first full term pregnancy, and duration of breastfeeding with the risk of breast cancer. Cancer and Steroid Hormone Study Group. J Clin Epidemiol 42: 963–73

    Article  PubMed  CAS  Google Scholar 

  21. Rebbeck TR, Wang Y, Kantoff PW et al. (2001) Modification of B. Cancer Res 61: 5420–4

    PubMed  CAS  Google Scholar 

  22. Cullinane CA, Lubinski J, Neuhausen SL et al. (2005) Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers. Int J Cancer 11: 988–91

    Article  CAS  Google Scholar 

  23. Gemignani ML, Petrek JA (2000) Pregnancy-Associated Breast Cancer: Diagnosis and Treatment. Breast J 6: 68–73

    Article  PubMed  Google Scholar 

  24. Tryggvadottir L, Olafsdottir EJ, Gudlaugsdottir S et al. (2003) BRCA2 mutation carriers, reproductive factors and breast cancer risk. Breast Cancer Res 5: R121–8

    Article  PubMed  CAS  Google Scholar 

  25. Russo J, Hu YF, Yang X, Russo IH (2000) Developmental, cellular, and molecular basis of human breast cancer. J Natl Cancer Inst Monogr 17–37

    Google Scholar 

  26. Jernstrom H, Lubinski J, Lynch HT et al. (2004) Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst 96: 1094–8

    Article  PubMed  CAS  Google Scholar 

  27. Collaborative group on hormonal factors in breast cancer (2002) Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease. Lancet 360: 187–95

    Article  Google Scholar 

  28. Jernstrom H, Johannsson O, Borg A et al. (1998) BRCA1-positive patients are small for gestational age compared with their unaffected relatives. Eur J Cancer 34: 368–71

    Article  PubMed  CAS  Google Scholar 

  29. Yang CP, Weiss NS, Band PR et al. (1993) History of lactation and breast cancer risk. Am J Epidemiol 138: 1050–6

    PubMed  CAS  Google Scholar 

  30. Boyd NF, Lockwood GA, Martin LJ et al. (1999) Mammographic densities and risk of breast cancer among subjects with a family history of this disease. J Natl Cancer Inst 91: 1404–8

    Article  PubMed  CAS  Google Scholar 

  31. Russo J, Lynch H, Russo IH (2001) Mammary gland architecture as a determining factor in the susceptibility of the human breast to cancer. Breast J 7: 278–91

    Article  PubMed  CAS  Google Scholar 

  32. Mitchell G, Antoniou AC, Warren R et al. (2006) Mammographic density and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Res 66: 1866–72

    Article  PubMed  CAS  Google Scholar 

  33. Rebbeck TR, Levin AM, Eisen A et al. (1999) Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers. J Natl Cancer Inst 91: 1475–9

    Article  PubMed  CAS  Google Scholar 

  34. Rossouw JE, Anderson GL, Prentice RL et al. (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 288: 321–33

    Article  PubMed  CAS  Google Scholar 

  35. Rebbeck TR, Friebel T, Wagner T et al. (2005) Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group. J Clin Oncol 23: 7804–10

    Article  PubMed  CAS  Google Scholar 

  36. World Cancer Research Fund/American Institute for Cancer Research (1997) Expert report. Food, nutrition and the prevention of cancer: a global perspective. Washington, DC: American Institute for Cancer Research

    Google Scholar 

  37. Collaborative group on hormonal factors in breast cancer (2002) Alcohol, tobacco and breast cancer — collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer 87: 1234–45

    Article  Google Scholar 

  38. Nkondjock A, Ghadirian P, Kotsopoulos J et al. (2006) Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. Int J Cancer 118: 103–7

    Article  PubMed  CAS  Google Scholar 

  39. Nagata C, Kabuto M, Shimizu H (1998) Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women. Nutr Cancer 30: 21–4

    Article  PubMed  CAS  Google Scholar 

  40. Huber WW, Scharf G, Rossmanith W et al. (2002) The coffee components kahweol and cafestol induce gamma-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat. Arch Toxicol 7: 685–94

    Article  CAS  Google Scholar 

  41. Clifford MN, Copeland EL, Bloxsidge JP, Mitchell LA (2000) Hippuric acid as a major excretion product associated with black tea consumption. Xenobiotica 30: 317–26

    Article  PubMed  CAS  Google Scholar 

  42. Rodriguez de Sotillo DV, Hadley M (2002) Chlorogenic acid modifies plasma and liver concentrations of: cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats. J Nutr Biochem 3: 717–26

    Article  Google Scholar 

  43. Shearer J, Farah A, de Paulis T et al. (2003) Quinides of roasted coffee enhance insulin action in conscious rats. J Nutr 133: 3529–32

    PubMed  CAS  Google Scholar 

  44. Lee WJ, Zhu BT (2006) Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols. Carcinogenesis 27: 269–77

    Article  PubMed  CAS  Google Scholar 

  45. Nkondjock A, Robidoux A, Paredes Y et al. (2006). Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians. Brest Cancer Res Treat 98: 285–94

    Article  CAS  Google Scholar 

  46. Sarkar NH, Fernandes G, Telang NT et al. (1982) Low-calorie diet prevents the development of mammary tumors in C3H mice and reduces circulating prolactin level, murine mammary tumor virus expression, and proliferation of mammary alveolar cells. Proc Natl Acad Sci USA 79: 7758–62

    Article  PubMed  CAS  Google Scholar 

  47. Hursting SD, Lavigne JA, Berrigan D et al. (2003) Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Annu Rev Med 54: 131–52

    Article  PubMed  CAS  Google Scholar 

  48. Key TJ, Verkasalo PK, Banks E (2001) Epidemiology of breast cancer. Lancet Oncol 2: 133–40

    Article  PubMed  CAS  Google Scholar 

  49. Pujol P, Galtier-Dereure F, Bringer J (1997) Obesity and breast cancer risk. Hum Reprod 12 Suppl 1: 116–25

    PubMed  Google Scholar 

  50. Grabrick DM, Anderson VE, King RA et al. (1999) Inclusion of risk factor covariates in a segregation analysis of a population-based sample of 426 breast cancer families. Genet Epidemiol 16: 150–64

    Article  PubMed  CAS  Google Scholar 

  51. Wenten M, Gilliland FD, Baumgartner K, Samet JM (2002) Associations of weight, weight change, and body mass with breast cancer risk in Hispanic and non-Hispanic white women. Ann Epidemiol 12: 435–4

    Article  PubMed  Google Scholar 

  52. Kotsopoulos J, Olopado OI, Ghadirian P et al. (2005) Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res 7: R833–43

    Article  PubMed  CAS  Google Scholar 

  53. Lagerros YT, Hsieh SF, Hsieh CC (2004) Physical activity in adolescence and young adulthood and breast cancer risk: a quantitative review. Eur J Cancer Prev 13: 5–12

    Article  PubMed  CAS  Google Scholar 

  54. King MC, Marks JH, Mandell JB (2003) Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 302: 643–6

    Article  PubMed  CAS  Google Scholar 

  55. Brunet JS, Ghadirian P, Rebbeck TR et al. (1998) Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes. J Natl Cancer Inst 90: 761–6

    Article  PubMed  CAS  Google Scholar 

  56. Ghadirian P, Lubinski J, Lynch H et al. (2004) Smoking and the risk of breast cancer among carriers of BRCA mutations. Int J Cancer 110: 413–6

    Article  PubMed  CAS  Google Scholar 

  57. Colilla S, Kantoff PW, Neuhausen SL et al. (2006) The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers. Carcinogenesis 27: 599–605

    Article  PubMed  CAS  Google Scholar 

  58. Johnson KC (2005) Accumulating evidence on passive and active smoking and breast cancer risk. Int J Cancer 117: 619–28

    Article  PubMed  CAS  Google Scholar 

  59. Macmahon B, Andersen AP, Brown J et al. (1980) Urine estrogen profiles in European countries with high or low breast cancer rates. Eur J Cancer 16: 1627–32

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ministère de la Défense, Direction de la santé militaire, BP 3226, Yaoundé, Cameroun

    A. Nkondjock

Authors
  1. A. Nkondjock
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer-Verlag France

About this chapter

Cite this chapter

Nkondjock, A. (2007). Facteurs de risque des cancers du sein familiaux. In: Le cancer du sein. Oncologie pratique. Springer, Paris. https://doi.org/10.1007/978-2-287-36073-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-2-287-36073-2_2

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-287-36071-8

  • Online ISBN: 978-2-287-36073-2

Publish with us

Policies and ethics

Search

Navigation