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Métastase des cellules cancéreuses : caractéristiques de l’envahissement osseux

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Métastases vertébrales

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La métastase est définie par la capacité des cellules tumorales à quitter la tumeur primitive, à migrer et à s’implanter dans un organe à distance puis à proliférer, formant ainsi de nouveaux foyers tumoraux. La dissémination métastatique est associée à l’invasivité tissulaire locale des cellules tumorales, caractérisée par la propriété de ces cellules de pénétrer et de migrer dans les tissus normaux voisins du foyer tumoral. La métastase caractérise les tumeurs malignes (28) bien que certaines cellules normales possèdent cette même capacité à quitter leur tissu d’origine. Ces phénomènes de migration cellulaire sont observés par exemple chez l’embryon au cours de la migration des cellules vers le thymus ou chez l’adulte lors bryon d’une réaction immunitaire au cours de la migration et prolifération de cellules lymphomonocytaires dans les ganglions. Cependant, ces événements physiologiques ou physiopathologiques qui aboutissent à la prolifération de cellules tissent normales dans des sites particuliers obéissent à des signaux d’arrêt de prolifération stricts, liés le plus souvent à la différenciation ou à l’apoptose des cellules concernées. Les cellules tumorales échappent à ces contrôles, prolifèrent dans les organes atteints, formant des foyers secondaires, souvent multiples.

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Authors and Affiliations

  1. INSERM - Section de Recherche, Institut Curie, 26, rue d’Ulm, 75248, Paris Cedex 05

    Marie-France Poupon

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  1. Marie-France Poupon
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  1. Service de Chirurgie Orthopédique et Réparatrice, Hôpital Pellegrin-Tripode, Place Amélie-Raba-Léon, 33076, Bordeaux Cedex

    Vincent Pointillart

  2. Service d’oncologie médicale, Hôpital Saint-André - CHU Bordeaux, 1, rue Jean Burguet, 33075, Bordeaux Cedex

    Alain Ravaud

  3. Institut Bergonié, 229, cours de l’Argonne, 33076, Bordeaux Cedex

    Jean Palussière

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Poupon, MF. (2007). Métastase des cellules cancéreuses : caractéristiques de l’envahissement osseux. In: Pointillart, V., Ravaud, A., Palussière, J. (eds) Métastases vertébrales. Springer, Paris. https://doi.org/10.1007/978-2-287-33744-4_3

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  • DOI: https://doi.org/10.1007/978-2-287-33744-4_3

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-287-33743-7

  • Online ISBN: 978-2-287-33744-4

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