Abstrait
La caractéristique particulière de ľadaptation au jeûne prolongé observée chez ľHomme, mais également chez certains oiseaux (migrateurs, pingouins), est principalement liée à la capacité ďépargne des protéines corporelles. Cette épargne azotée est rendue possible par différents mécanismes physiologiques responsables ďune modification des priorités de ľorganisme et de ľutilisation des substrats. Cette facilité à résister à ľabsence ďapports alimentaires exogènes est très liée à ľévolution même de ľHomme, du fait des caractéristiques métaboliques et physiologiques imposées par le développement de son cerveau. Il est intéressant de noter que la faculté de stocker des réserves avec un maximum ďefficacité, conjuguée à ľutilisation très efficiente de ces substrats, a permis à ľHomme de survivre et même de se développer dans des conditions très peu favorables du point de vue alimentaire, ceci jusqu’à une période très récente de ľHistoire en Europe mais également actuellement dans de nombreux, pays en voie de développement, la disponibilité alimentaire restant au premier rang des défis auxquels ľespèce humaine doit faire face.
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Références générales
Cahill G (1970) Starvation in man. N Engl J Med 282: 668–75
Hoffer L (1994) Sarvation. In: Shils M, Olson J, Shike M, eds. Modern nutrition in health and disease. Malvern (PA), Lea and Febiger, 927–49
Elia M (1991) Effect of starvation and very low calorie diets on protein-energy interrelationships in lean and obese subjects. In: Nestlé, ed. Protein-energy Interactions. Lausanne: IDEGC 249–84
Bogardus C, Lillioja S, Ravussin E (1990) The pathogenesis of obesity in man: results of studies on Pima Indians. Int J Obes 14(suppl 1): 5–13; discussion 13–5
Le Maho Y, Robin J, Cherel Y (1988) Starvation as a treatment for obesity: the need to conserve body protein. News Physiol Sci 3: 21–4
Références
Aoki TT (1981) Metabolic adaptations to starvation, semistarvation, and carbohydrate restriction. Prog Clin Biol Res 67: 161–77
Barnard D, Ford J, Garnett F et al. (1969) Changes in body composition produced by prolonged total starvation and refeeding. Metabolism 18: 564–9.
Beaufrère B, Chassard D, Brousolle C et al. (1992) Effects of D-ß-hydroxybutyrate, long and medium chain triglycerides on leucine metabolism in man. Am J Physiol 262: E268–74.
Belkhou R, Béchet D, Cherel Y (1994) Effect of fasting and thyroïdectomy on cysteine proteinase activities in liver and muscle. Biochim Biophys Acta 119: 195–201
Belkhou R, Cherel Y, Heitz A et al. (1991) Energy contributions of proteins and lipids during prolonged fasting in the rat. Nutr Res 11: 365–74
Beyerley L, Heber D (1996) Metabolic effects of triiodothyronine replacement during fasting in obese subjects. J Clin Endocrinol Metab 81: 968–76
Bogardus C, Lillioja S, Ravussin E (1990) The pathogenesis of obesity in man: results of studies on Pima Indians. Int J Obes 14 (suppl 1): 5–13; discussion 13–5
Boirie Y, Beaufrère B (1995) Control of amino acid metabolism by lipid, ketone bodies and glucose substrates. In: Cynober L, ed. Amino acid metabolism and therapy in health and nutritional disease. New York, CRC Press 157–65
Botbol V, Scornik OA (1991) Measurement of instant rates of protein degradation in the livers of intact mice by the accumulation of bestatin-induced peptides. J Biol Chem 266(4): 2151–7
Botbol V, Scornik OA (1997) Measurement of muscle protein degradation in live mice by accumulation of bestatin-induced peptides. Am J Physiol 273(6 Pt 1): E1149–57
Botbol V, Scornik OA (1989) Role of bestatin-sensitive exopeptidases in the intracellular degradation of hepatic proteins. J Biol Chem 264(23): 13504–9
Cahill G (1970) Starvation in man. N Engl J Med 282: 668–75
Cahill G, Herrera M, Morgan A (1966) Hormone-fuel interrelationships during fasting. J Clin Invest 45: 1751–69
Cahill GF Jr, Aoki TT (1970) Starvation and body nitrogen. Trans Am Clin Climatol Assoc 82: 43–51
Carpentier Y, Thonnart N (1987) Lipids in clinical nutrition. In: Horisberger M, Bracco U, eds. Lipids in modern nutrition. New York, Raven Press 147–55
Cherel Y, Attaix D, Rosolowska-Huszcz D et al. (1991) Wholebody and tissue protein synthesis during brief and prolonged fasting in the rat. Clin Sci 81: 611–9
Cherel Y, Burnol A, Leturque A, Le Maho Y (1988) In vivo glucose utilization in rat tissues during the three phases of starvation. Metabolism 37: 1033–9
Cherel Y, Le Maho Y (1985) Five months of fasting in king penguin chicks: body mass and fuel metabolism. Am J Physiol 249: R387–92
Cherel Y, Leloup J, Le Maho Y (1988) Fasting in king penguin. II. Hormonal and metabolic changes during molt. Am J Physiol 254(2 Pt 2): R178–84
Cherel Y, Robin J, Heitz A et al. (1992) Relationships between lipid availability and protein utilization during prolonged fasting. J Comp Physiol B 162: 305–13
Cherel Y, Robin J, Le Maho Y (1988) Physiology and biochemistry of long term fasting in birds. Can J Zool 66: 159–66
Cohen CY (1987) Energy metabolism in the brain, adaptation towards starvation. Med Hypotheses 24(2): 177–8
Collins S (1995) The limit of human adaptation to starvation. Nature Medicine 1: 810
Davis T, Fiorotto M, Nguyen H et al. (1991) Response of muscle protein synthesis of fasting in suckling and weaned rats. Am J Physiol 261: 1373–80
Elia M (1991) Effect of starvation and very low calorie diets on protein-energy interrelationships in lean and obese subjects. In: Nestlé, ed. Protein-energy Interactions. Lausanne: IDEGC 249–84
Felig P (1973) The glucose-alanine cycle. Metabolism 22: 179–207
Fery F, Balasse E (1980) Differential effects of sodium acetoacetate and acetoacetic acid infusion on alanine metabolism in man. J Clin Invest 66: 323–31
Goodman M, Larsen P, Kaplan M (1980) Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism. Am J Physiol 239: E277–86
Hasselbalch SG, Knudsen GM, Jakobsen J (1995) Blood-brain barrier permeability of glucose and ketone bodies during shorterm starvation in humans. Am J Physiol 268(6 Pt 1): E1161–6
Hasselbalch SG, Knudsen GM, Jakobsen J et al. (1994) Brain metabolism during short-term starvation in humans. J Cereb Blood Flow Metab 14(1): 125–31
Hasselbalch SG, Madsen PL, Hageman LP et al. (1996) Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am J Physiol 270(5 Pt 1): E746–51
Henry C (1990) Body mass index and the limits of human survial. Eur J Clin Nutr 44: 324–35
Hoffer L (1994) Starvation. In: Shils M, Olson J, Shike M, eds. Modern nutrition in health and disease. Malvern (PA), Lea and Febiger 927–49
Hoffer L, Bistrian B, Young V et al. (1984) Metabolic effects of very low calorie weight reduction diets. J Clin Invest 3: 750–8
Hoffer L, Forse R (1990) Protein metabolic effects of a prolonged fast and hypocaloric refeeding. Am J Physiol 258: E832–40
Howard BV, Bogardus C, Ravussin E et al. (1991) Studies of the etiology of obesity in Pima Indians. Am J Clin Nutr 53(suppl 6): S1577–85
Koubi H, Robin J, Dewasmes G (1991) Fasting induced rise in locomotor activity in rats coincides with increased protein utilization. Physiol Behav 50: 337–42
le Maho Y, Robin J, Cherel Y (1988) Starvation as a treatment for obesity: the need to conserve body protein. News Physiol Sci 3: 21–4
Le Maho Y, Vu Van Kha H, Koubi H et al. (1981) Body composition, energy expenditure, and plasma metabolites in long term fasting geese. Am J Physiol 241: E342–54
Le Ninan F, Cherel Y, Robin JP et al. (1988) Early changes in plasma hormones and metabolites during fasting in king penguin chicks. J Comp Physiol [B] 158(4): 395–401
Leturque A, Hauguel S, Revelli JP et al. (1989) Fetal glucose utilization in response to maternal starvation and acute hyperketonemin Am J Physiol 256 (6 Pt 1): E699–703
Leverve X (1995) Amino acid metabolism and gluconeogenesis. In: Cynober L, ed. Amino acid metabolism and therapy in health and nutritional disease. New York, CRC Press 45–56
Leverve X (1994) Dénutrition. In: Hillon P, Le Jeune C, Aubert P, eds. Thérapeutique. De la physiologie au traitement. Paris, Frison-Roche 107–24
Leverve X (1996) Perturbations métaboliques au cours de ľagression: bases physiopathologiques et concepts thérapeutiques. Nutrition artificielle en réanimation. Paris, Arnette 3–16
Leverve X, Mustafa I, Péronnet F (1998) Pivotal role of lactate in aerobic metabolism. In: Vincent J, ed. Yearbook of intensive care and emergency medicine. Berlin, Springer Verlag 588–96
Marcilloux JC, Simon J, Auffray P (1985) Effects of V.M.H. lesions on plasma insulin in the goose. Physiol Behav 35(5): 725–8
Medina JM, Tabernero A, Tovar JA, Martin-Barrientos J (1996) Metabolic fuel utilization and pyruvate oxidation during the postnatal period. J Inherit Metab Dis 19(4): 432–42
Medina R, Wing S, Goldberg A (1995) Increase in levels of polyubiquitin and proteasome mRNA, in skeletal muscle during starvation and denervation atrophy. Biochem J 307: 631–7
Nair K, Halliday D, Ford G, Garrow J (1989) Effects of triiodothyronine on leucine kinetics, metabolic rate, glucose concentration and insulin secretion rate during two weeks of fasting in obese women. Int J Obes 13: 487–96
Nair K, Wololf P, Welle S, Matthews DE (1987) Leucine, glucose and energy metabolism after 3 days of fasting in healthy human subjects. Am J Clin Nutr 46: 557–62
Owen OE, Reichard GA Jr (1971) Human forearm metabolism during progressive starvation. J Clin Invest 50(7): 1536–45
Ravussin E (1993) Energy metabolism in obesity. Studies in the Pima Indians. Diabetes Care 16(1): 232–8
Robin J, Frain M, Sardet C et al. (1988) Protein and lipid utilization durin long term fasting in emperor penguins. Am J Physiol 254: R61–8
Scornik OA (1984) Role of protein degradation in the regulation of cellular protein content and amino acid pools. Fed Proc 43(5): 1283–8
Scornik OA, Howell SK, Botbol V (1997) Protein depletion and replenishment in mice: different roles of muscle and liver. Am J Physiol 273 (6 Pt 1): E1158–67
Shambaugh GE (1985) Ketone body metabolism in the mother and fetus. Fed Proc 44 (7): 2347–51
Sherwin R, Hendler R, Felig P (1975) Effect of ketone infusions on aminoacid and nitrogen metabolism in man. J Clin Invest 55: 1382–90
Sitbon G, Mialhe P (1980) The endocrine pancreas of birds. J Physiol (Paris) 76 (1): 5–24
Sokoloff L (1973) Metabolism of ketone bodies by the brain. Annu Rev Med 24: 271–80
Streja D, Steiner G, Marliss E, Vranic M (1977) Turn over and recycling of glucose in man during prolongated starvation. Metabolism 26: 1089–98
Umpleby A, Scobie I, Sönksen P (1991) The effrect of starvation on leucine, alanine and glucose metabolism in obese subjects. Eur J Clin Invest 25: 619–25
Vasquez J, Morse E, Adibi S (1985) Effect of dietary fact, carbohydrate and protein on branched-amino acid catabolism in obese subjects. J Clin Invest 76: 737–43
Wing S, Haas A, Goldberg A (1995) Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat squeletal muscle during starvation and atrophy denervation. Biochem J 307: 639–45
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Beaufrère, B., Leverve, X. (2007). Physiologie du jeûne. In: Traité de nutrition artificielle de l’adulte. Springer, Paris. https://doi.org/10.1007/978-2-287-33475-7_31
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DOI: https://doi.org/10.1007/978-2-287-33475-7_31
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