Abstract
Primary liver cancer or hepatocellular carcinoma (HCC) is a tumor of the hepatocyte, the specialized liver epithelial cell that is responsible for most liver function. It is the most common cancer that originates in the liver (primary cancer). By contrast, liver metastases have spread to the liver from cancers arising in other organs and are not further considered here.
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Hosaka T, Suzuki F, Kobayashi M, et al. Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection. Hepatology. 2013;58:98-107.
Hsu YC, Ho HJ, Wu MS, Lin JT, Wu CY. Postoperative peg-interferon plus ribavirin is associated with reduced recurrence of hepatitis C virus-related hepatocellular carcinoma. Hepatology. 2013;58:150-157.
Wu SD, Ma YS, Fang Y, Liu LL, Fu D, Shen XZ. Role of the microenvironment in hepatocellular carcinoma development and progression. Cancer Treat Rev. 2012;38:218-225.
Yang JD, Nakamura I, Roberts LR. The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets. Semin Cancer Biol. 2011;21:35-43.
Hernandez-Gea V, Toffanin S, Friedman SL, Llovet JM. Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma. Gastroenterology. 2013;144:512-527.
Carr BI, Guerra V. HCC and its microenvironment. Hepatogastroenterology. 2013;60:1433-1437.
Paget S. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev. 1989;8:98-101.
Kinoshita A, Onoda H, Imai N, et al. The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma. BMC Cancer. 2013;13:52.
Carr BI, Laishes BA. Carcinogen-induced drug resistance in rat hepatocytes. Cancer Res. 1981;41:1715-1719.
Haddow A. Cellular inhibition and the origin of cancer. Acta Unio Int Concra Cancer. 1938;3:342-352.
Carr BI, Guerra V, Giannini EG, et al; Italian Liver Cancer (ITA.LI.CA) Group. Association of abnormal plasma bilirubin with aggressive hepatocellular carcinoma phenotype. Semin Oncol. 2014;41:252-258.
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Carr, B.I. (2014). Introduction to hepatocellular carcinoma: A tale of two diseases. In: Understanding Liver Cancer. Springer Healthcare, Tarporley. https://doi.org/10.1007/978-1-910315-02-6_1
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DOI: https://doi.org/10.1007/978-1-910315-02-6_1
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