Abstract
The available treatments for diabetes all have limitations, either because of side effects (particularly weight gain and hypoglycemia) or due to contraindications; hence there has been an increased emphasis on the development of newer and more effective agents for lowering glucose.
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References
Pfutzner A, Mann AE, Steiner SS. Technosphere/insulin: a new approach for effective delivery of human insulin via the pulmonary route. Diabetes Techol Ther. 2002;509–594.
Rosenstock J, Lorber DL, Gnudi L, et al. Prandial inhaled insulin plus basal insulin glargine versus twice-daily biaspart insulin for type 2 diabetes: a multicentre randomised trial. Lancet. 2010;375:2244–2253.
Kling J. Dreamboat sinks prospects for fast approval of inhaled insulin. Nature Biotech. 2011;29:175–176.
Bailey CJ, Gross LJ, Pieters A, et al. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet. 2010;375:2223–2233.
Nauck MA, Del Prato S, Meier JJ, et al. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care. 2011;34:2015–2022.
Nauck M, Del Prato S, Rohwedder K, Theuerkauf A, Langkilde AM, Parikh S. Long-term efficacy and safety of add-on dapagliflozin vs add-on glipizide in patients with T2DM inadequately controlled with metformin: 2-year results. Poster presented at the 71st Scientific Sessions of the American Diabetes Association, June 24–28, 2011; San Diego, California.
Ferrannini E, Ramos SJ, Salsali A, Tang W, List JF. Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Care. 2010;3322:2217–2224.
Aires I, Calado J. BI-10773, a sodium-glucose cotransporter 2 inhibitor for the potential oral treatment of type 2 diabetes mellitus. Curr Opin Investig Drugs. 2010;11:1182–1190.
Anderson SL, Marrs JC. Dapagliflozin for the treatment of type 2 diabetes. Ann Pharmacother. 2012;46:590–598.
Gregoire FM, Zhang F, Clarke HJ, et al. MBX-102/JNJ39659100, a novel peroxisome proliferatoractivated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009;23:975–988.
INT131-004 Study Group. Selective modulation of PPARγ activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with type 2 diabetes. J Diabetes Complications. 2011;25:151–158.
Higgins LS, DePaoli AM. Selective peroxisome proliferator-activated receptor γ (PPARγ) modulation as a strategy for safer therapeutic PPARg activation. Am J Clin Nutr. 2010;91(suppl):267S–272S.
Balakumar P, Rose M, Subrahmanya S, et al. PPAR dual agonists: Are they opening Pandora’s box? Pharmacological Res. 2007;56:91–98.
Lecka-Czernik B. Aleglitazar, a dual PPARα and PPARγ agonist for the potential oral treatment of type 2 diabetes mellitus. IDrugs. 2010;11:793–807.
Matschinsky FM, Porte D Jr. Glucokinase activators (GKAs) promise a new pharmacotherapy for diabetics. F1000 Med Rep. 2010;2:43–48.
Sorensen H, Brand CL, Neschan S, et al. Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice. Diabetes. 2006;55:2843–2848.
Finkel T, Deng CX, Mostoslavsky R, et al. Recent progress in the biology and physiology of sirtuins. Nature. 2009;460:587–591.
Banks AS, Kon N, Knight C, et al. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 2008;8:333–341.
Haigis MC, Mostoslavsky R, Haigis KM, et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006;126:941–954.
Lim CS. SIRT1: tumor promoter or tumor suppressor? Med Hypotheses. 2006;67:341–344.
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Shankarnarayan, S., Sreemantula, G. (2012). New and Future Therapies. In: Vora, J., Evans, M. (eds) Managing Diabetes. Springer Healthcare, Tarporley. https://doi.org/10.1007/978-1-908517-81-4_5
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DOI: https://doi.org/10.1007/978-1-908517-81-4_5
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