Skip to main content
  • 1132 Accesses

Abstract

Parkinson’s disease (PD) patients commonly present with severe or intractable pain, which some patients find more distressing than the motor disability [1]. Furthermore, PD-related pain can present in a variety of types (Fig. 11.1) and, in up to a quarter of patients, chronic pain precedes the onset of motor symptoms or the start of anti-parkinsonian treatment. However, despite being almost ubiquitous, pain in PD patients often remains poorly managed. In one study, 83 % of PD patients reported pain, but only 34 % received analgesics [2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hanagasi HA, Akat S, Gurvit H, et al. Pain is common in Parkinson’s disease. Clin Neurol Neurosurg 2010;113:11-13

    Google Scholar 

  2. Beiske AG, Loge JH, Ronningen A, Svensson E. Pain in Parkinson’s disease: Prevalence and characteristics. Pain 2009;141;173-177.

    Google Scholar 

  3. Chaudhuri K, Schapira A. Non-motor symptoms of Parkinson’s disease: dopaminergic pathophysiology and treatment. Lancet Neurol 2009;8:464-474.

    Google Scholar 

  4. Brefel-Courbon C, Payoux P, Thalamas C, et al. Effect of levodopa on pain threshold in Parkinson’s disease: a clinical and positron emission tomography study. Mov Disord 2005;20:1557-1563.

    Google Scholar 

  5. Schestatsky P, Kumru H, Valls-Sole J, et al. Neurophysiologic study of central pain in patients with Parkinson disease. Neurology 2007;69:2162-2169.

    Google Scholar 

  6. Trenkwalder C, Kies B, Rudzinska M, et al; and the RECOVER study group. Rotigotine effects on early morning motor function and sleep in Parkinson’s disease: A double-blind, randomised, placebo-controlled study (RECOVER). Mov Disord 2011;26:90-99.

    Google Scholar 

  7. Kassubek J, Ghys L, Chaudhuri KR, et al; on behalf of the RECOVER study investigators. Transdermal rotigotine improves pain in patients with Parkinson’s disease: a post hoc analysis of the RECOVER Study. Poster presented at: Deutschen Gesellschaft für Neurologie (DGN), 84th Annual Congress; September 28-October 1, 2011; Wiesbaden, Germany.

    Google Scholar 

  8. Park A, Stacy M. Non-motor symptoms in Parkinson’s disease. J Neurol 2009;256:293-298.

    Google Scholar 

  9. Lou JS. Physical and mental fatigue in Parkinson’s disease: epidemiology, pathophysiology and treatment. Drugs Aging 2009;26:195-208.

    Google Scholar 

  10. Larsen JP, Karlsen K, Tandberg E. Clinical problems in non-fluctuating patients with Parkinson’s disease: A community based study. Mov Disord 2000;15:826-829.

    Google Scholar 

  11. Herlofson K and Larsen JP. The influence of fatigue on health-related quality of life in patients with Parkinson’s disease. Acta Neurol Scand 2003;107:1-6.

    Google Scholar 

  12. Beiske AG, Svensson E. Fatigue in Parkinson’s disease: a short update. Acta Neurol Scand Suppl 2010;190:78-81.

    Google Scholar 

  13. Havlikova E, Rosenberger J, Nagyova I, et al. Clinical and psychosocial factors associated with fatigue in patients with Parkinson’s disease. Parkinsonism Relat Disord 2008;14:187-192.

    Google Scholar 

  14. Pavese N, Metta V, Bose SK, et al. Fatigue in Parkinson’s disease is linked to striatal and limbic serotonergic dysfunction. Brain 2010;133:3434-3443.

    Google Scholar 

  15. Chaudhuri KR, Friedman JH, Surmann E, et al; on behalf of the RECOVER study investigators. The effects of transdermal rotigotine on mood/cognition: interpretations from a post hoc analysis of the RECOVER Study using the Parkinson’s disease Non-Motor Symptom Scale. Poster presented at: 15th International Congress of Parkinson’s Disease and Movement Disorders; June 5-9, 2011; Toronto, Canada.

    Google Scholar 

  16. Korczyn AD, Gurevich T. Parkinson’s disease: before the motor symptoms and beyond. J Neurol Sci 2010;289:2-6.

    Google Scholar 

  17. Barichella M, Cereda E, Pezzoli G. Major nutritional issues in the management of Parkinson’s disease. Mov Disord 2009;24:1881-1892.

    Google Scholar 

  18. Kashihara K. Weight loss in Parkinson’s disease. J Neurol 2006;253(suppl 7):VII38-VII41.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Healthcare, a part of Springer Science+Business Media

About this chapter

Cite this chapter

Chaudhuri, K.R. (2011). Other Symptoms. In: Handbook of Non-Motor Symptoms in Parkinson's Disease. Springer Healthcare, Heidelberg. https://doi.org/10.1007/978-1-908517-60-9_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-908517-60-9_11

  • Published:

  • Publisher Name: Springer Healthcare, Heidelberg

  • Print ISBN: 978-1-907673-23-8

  • Online ISBN: 978-1-908517-60-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics