Clinical Consequences of the Role of Glutamate and Neuroplasticity in Depressive Disorder

  • Philip Gorwood


Convergent and compelling data exist showing that glutamatergic modulation forms the basis of the effect of antidepressants in major depressive disorder, through its impact on neuroplasticity. However, a significant part of available information is based on animal studies, preclinical works and clinical research, and therefore this hypothesis has to be challenged at a broader clinical level.


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  • Philip Gorwood

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