• Anthony A Bavry
  • Deepak L Bhatt


This chapter reviews the key elements in the pathophysiology and natural history of atherosclerosis. The interaction between the coagulation cascade and platelet physiology will also be discussed. Our understanding of the complex pathophysiology of atherosclerosis, the coagulation cascade, and platelet physiology is important in order to optimize pharmaceutical and device therapy.


Acute Coronary Syndrome Plaque Rupture Coagulation Cascade Necrotic Core Vulnerable Plaque 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Libby P. Molecular bases of the acute coronary syndromes. Circulation 1995; 91:2844–2850.CrossRefGoogle Scholar
  2. 2.
    Kolodgie FD, Burke AP, Farb A, et al. The thin-cap fibroatheroma: a type of vulnerable plaque: the major precursor lesion to acute coronary syndromes. Curr Opin Cardiol 2001; 16:285–292.CrossRefGoogle Scholar
  3. 3.
    Virmani R, Kolodgie FD, Burke AP, et al. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2000; 20:1262–1275.CrossRefGoogle Scholar
  4. 4.
    Libby P, Theroux P. Pathophysiology of Coronary Artery Disease. Circulation 2005; 111:3481–3488.CrossRefGoogle Scholar
  5. 5.
    Burke AP, Kolodgie FD, Farb A, et al. Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression. Circulation 2001; 103:934–940.CrossRefGoogle Scholar
  6. 6.
    Ambrose JA, Tannenbaum MA, Alexopoulos D, et al. Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol 1988; 12:56–62.CrossRefGoogle Scholar

Copyright information

© Current Medicine Group, a part of Springer Science+Business Media 2008

Authors and Affiliations

  • Anthony A Bavry
    • 1
  • Deepak L Bhatt
    • 1
  1. 1.Department of Cardiovascular MedicineCleveland ClinicUSA

Personalised recommendations