Abstract
Methotrexate is an antimetabolite agent that is very similar in structure to folic acid (folic acid analogue) [1]. Aminopterine, another folic acid analogue and a methotrexate precursor, was used first for the treatment of rheumatoid arthritis (RA) and psoriasis by Gubner and Ginsberg in 1951 [2].
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© 2015 Springer Healthcare
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Sandoval, D., Alarcón, G.S. (2015). Methotrexate. In: Emery, P. (eds) Atlas of Rheumatoid Arthritis. Springer Healthcare, Tarporley. https://doi.org/10.1007/978-1-907673-91-7_9
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DOI: https://doi.org/10.1007/978-1-907673-91-7_9
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