Skip to main content

What is the Cause of Renal Anemia?

  • Chapter
  • First Online:
Pocket Reference to Renal Anemia
  • 906 Accesses

Abstract

The pathogenesis of renal anemia is multifactorial, with a number of contributory processes involved, to a greater or lesser extent.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 49.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Caro J, Brown S, Miller O, et al. Erythropoietin levels in uremic nephric and anephric patients. J Lab Clin Med. 1979;93:449-458.

    Google Scholar 

  2. Fisher JW. Erythropoietin: physiology and pharmacology update. Exp Biol Med. 2003;228:1-14.

    Google Scholar 

  3. Lai PH, Everett R, Wang FF, et al. Structural characterization of human erythropoietin. J Biol Chem. 1986;261:3116-3121.

    Google Scholar 

  4. Browne JK, Cohen AM, Egrie JC. Erythropoietin: gene cloning protein structure and biological properties. Cold Spring Harbor Symp Quant Biol. 1986;51:693-702.

    Google Scholar 

  5. Bernhardt WM, Wiesener MS, Scigalla P, et al. Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD. J Am Soc Nephrol. 2010;21:2151-2156.

    Google Scholar 

  6. Allen DA, Breen C, Yaqoob MM, Macdougall IC. Inhibition of CFU-E colony formation in uremic patients with inflammatory disease: role of IFN-γ and TNF-α. J Investig Med. 1999;47:204-211.

    Google Scholar 

  7. Macdougall IC. Role of uremic toxins in exacerbating anemia in renal failure. Kidney Int Suppl. 2001;78: S67-S72.

    Google Scholar 

  8. Ifudu O, Feldman J, Friedman EA. The intensity of hemodialysis and the response to erythropoietin in patients with end-stage renal disease. N Engl J Med. 1996;334:420-425.

    Google Scholar 

  9. Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271-1276.

    Google Scholar 

  10. Babitt JL, Lin HY. Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD. Am J Kidney Dis. 2010;55:726-741.

    Google Scholar 

  11. Macdougall IC, Malyszko J, Hider RC, Bansal SS. Current status of the measurement of blood hepcidin levels in chronic kidney disease. Clin J Am Soc Nephrol. 2010;5:1681-1689.

    Google Scholar 

  12. Macdougall IC. Iron supplementation in nephrology and oncology: what do we have in common? Oncologist. 2011;16(suppl 3):25-34.

    Google Scholar 

  13. Eschbach JW, Cook JD, Scribner BH, Finch CA. Iron balance in hemodialysis patients. Ann Intern Med. 1977;87:710-713.

    Google Scholar 

  14. Urena P, Eckardt KU, Sarfati E, et al. Serum erythropoietin and erythropoiesis in primary and secondary hyperparathyroidism: effect of parathyroidectomy. Nephron. 1991;59:384-393.

    Google Scholar 

  15. McCarthy JT, Milliner DS, Johnson WJ. Clinical experience with desferrioxamine in dialysis patients with aluminium toxicity. Q J Med. 1990;74:257-276.

    Google Scholar 

  16. Wu SG, Jeng FR, Wei SY, et al. Red blood cell osmotic fragility in chronically hemodialyzed patients. Nephron. 1998;78:28-32.

    Google Scholar 

  17. Vos FE, Schollum JB, Coulter CV, Doyle TC, Duffull SB, Walker RJ. Red blood cell survival in long-term dialysis patients. Am J Kidney Dis. 2011;58:591-598.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Healthcare

About this chapter

Cite this chapter

Macdougall, I.C. (2013). What is the Cause of Renal Anemia?. In: Pocket Reference to Renal Anemia. Springer Healthcare, Tarporley. https://doi.org/10.1007/978-1-907673-48-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-907673-48-1_2

  • Published:

  • Publisher Name: Springer Healthcare, Tarporley

  • Print ISBN: 978-1-908517-74-6

  • Online ISBN: 978-1-907673-48-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics