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Chronic Ischemic Mitral Regurgitation

  • Jean-Louis VanoverscheldeEmail author
  • Gébrine El Khoury
  • Agnès Pasquet
Chapter

Abstract

Ischemic mitral regurgitation (MR) is mitral regurgitation due to complications of coronary artery disease, in particular myocardial infarction (MI), and not the fortuitous association of coronary artery disease with intrinsic valve disease such as degenerative, myxomatous, and connective tissue valvular disease, spontaneous ruptured chordae tendinae, and other causes of acute or chronic MR due to infection, inflammation, trauma, congenital abnormalities (including mitral valve (MV) prolapse), annular calcification, or tumor. Accordingly, the term ischemic MR should be restricted to chronic MR, occurring more than 2 weeks after MI and in the absence of structural MV disease. From a pathogenic point of view, it is a manifestation of postinfarction ventricular remodeling. The size, location, and transmurality of the MI sets in motion left ventricle (LV) remodeling that determines the severity, time course, and clinical manifestation of ischemic MR. The presentation develops insidiously over time in association with congestive heart failure.

Keywords

Mitral Regurgitation Cardiac Resynchronization Therapy Posterior Leaflet Ischemic Mitral Regurgitation Regurgitant Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag London Limited 2010

Authors and Affiliations

  • Jean-Louis Vanoverschelde
    • 1
    Email author
  • Gébrine El Khoury
  • Agnès Pasquet
  1. 1.Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et CliniqueUniversité catholique de LouvainBrusselsBelgium

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