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Systemic Lupus Erythematosus

  • Rüdiger Müller
  • Johannes von Kempis
Chapter

Corticosteroids

Trial

A double-blind controlled trial of methylprednisolone infusions in systemic lupus erythematosus using individualized outcome assessment

 

Substance

Three daily infusions of methylprednisolone 100 mg (n = 10)

Methylprednisolone 1 g (n = 11)

Alternative dose:

Nine patients who not responded satisfactorily to the first set of infusions were treated with a second set of infusions at the alternative dose

Concomitant medication:

No limitations about any other drug

Oral corticosteroids were withdrawn on the day of infusion

 

Result

Half of patients with severe episodes of systemic lupus erythematosus treated with infusions of methylprednisolone displayed improvement at 3 months, three doses of 1 g did not appear to have any advantage over three of 100 mg

 

Patients

21 SLE patients with active disease

Failed to chloroquine (no precise number of patients)

Failed to oral prednisolone (≤15 mg/day, n = 21)

Various features:

Febrile without evidence of infection

Cerebral or...

Keywords

Public Health Internal Medicine Systemic Lupus Erythematosus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer London 2010

Authors and Affiliations

  • Rüdiger Müller
    • 1
  • Johannes von Kempis
    • 1
  1. 1.Division of Rheumatology and Rehabilitation Department of Internal MedicineKantonsspital St. GallenSt. GallenSwitzerland

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