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Morbus Behçet

  • Rüdiger Müller
  • Johannes von Kempis
Chapter

Corticosteroids

Trial

A double-blind trial of depot corticosteroids in Behçet’s syndrome

 

Substance

40 mg methylprednisolone acetate (n = 42)

Placebo (n = 44)

Every 3 weeks for 27 weeks

Concomitant medication:

NSAIDs n = 1 (steroid), n = 4 (placebo)

Low dose aspirine n = 3 (steroid), n = 3 (placebo)

Amitriptyline n = 2 (steroid), n = 4 (placebo)

Colchicine n = 18 (steroid), n = 24 (placebo)

Previous medication:

Corticosteroids <5 mg/day were permitted

 

Result

Low-dose depot corticosteroids treatment of genital ulcers of patients suffering from Behçet’s syndrome did not have any beneficial effect on genital ulcers. Erythema nodosum lesions improved

 

Patients

86 Behçet’s syndrome patients

Who had active disease with ≥1 genital ulcers occurring ≤6 months

No severe organ involvement

 

Authors

Mat C, Yurdakul S, Uysal S, Gogus F, Ozyazgan Y, Uysal O, Fresko I, Yazici H

 

Publication

Rheumatology (Oxford). 2006;45(3):348–52. Epub 2005 Nov 1

 

Follow up

27 weeks

 

Note

Treatment period:

Gen...

Keywords

Public Health Internal Medicine Mycophenolate Mofetil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer London 2010

Authors and Affiliations

  • Rüdiger Müller
    • 1
  • Johannes von Kempis
    • 1
  1. 1.Division of Rheumatology and Rehabilitation Department of Internal MedicineKantonsspital St. GallenSt. GallenSwitzerland

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