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Rheumatoid Arthritis

  • Rüdiger Müller
  • Johannes von Kempis
Chapter

Corticosteroids

Trial

Pulsed methylprednisolone in active early rheumatoid disease: a dose-ranging study

 

Substance

1 ´ methylprednisolone 40 mg (n = 24)

1 ´ methylprednisolone 500 mg (n = 22)

1 ´ methylprednisolone 1g were (n = 23)

Concomitant medication:

No information provided

Previous medication:

No DMARD ≤ 6 months

No oral corticosteroidsw ≤ 6 months

 

Result

Single doses of methylprednisolone below 1g were not helpful in the management of acute RA

 

Patients

71 patients with active classical or definite RA

Deemed by the clinician to warrant second line treatment

Disease duration < 5 years

 

Authors

Shipley ME, Bacon PA, Berry H, Hazleman BL, Sturrock RD, Swinson DR, Williams IA

 

Publication

Br J Rheumatol. 1988 Jun;27(3):211–214

 

Follow up

9 weeks

 

Note

Patient did benefit from treatment n = 10 (40 mg), n = 13 (500 mg), n = 20 (1g)

Complete trial n = 9 (40 mg), n = 7 (500 mg), n = 16 (1g)

 

Adverse events

Total number of adverse events n = 15 (40 mg), n = 20 (500 mg), n = 32...

Copyright information

© Springer London 2010

Authors and Affiliations

  • Rüdiger Müller
    • 1
  • Johannes von Kempis
    • 1
  1. 1.Division of Rheumatology and Rehabilitation Department of Internal MedicineKantonsspital St. GallenSt. GallenSwitzerland

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