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Endothelial Protection During Heart Surgery and Lung Transplantation

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Principles of Pulmonary Protection in Heart Surgery

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Abstract

The edndothelium in the cardiovascular system is crucial in the regulation of systemic and pulmonary blood circulation. During heart and lung surgery, endothelial dysfunction occurs due to multiple factors, including ischemia-reperfusion injury and direct action of the cardioplegic and organ preservation solutions, as well as adjuncts to cardioplegic procedure. Maximally limiting ischemia-reperfusion injury and optimizing the formula of cardioplegic and preservation solutions are the future directions in surgery-related coronary and pulmonary endothelial protection.

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Acknowledgment

This work was supported by Hong Kong GRF grant (CUHK4651/07M and CUHK 4789/09M), CUHK direct grants 2041561 2041457 Providence St. Vincent Medical Foundation, Portland, Oregon, USA, and China National Ministry of Science and Technology Grands 2009 DFB 30560 and 2010 CB 529502 (973), Tianjin Municipal Science and Technology Commission great 09ZCZDSF04200.

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  1. Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China

    Qin Yang

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  1. Qin Yang
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  1. Federal University of Sao Paulo, Sao Paulo, 04023900, Brazil

    Edmo Atique Gabriel

  2. University of Miami, 1611 N.W. 12th Avenue, Miami, 33136, Florida, USA

    Tomas Salerno

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Yang, Q., He, GW. (2010). Endothelial Protection During Heart Surgery and Lung Transplantation. In: Gabriel, E., Salerno, T. (eds) Principles of Pulmonary Protection in Heart Surgery. Springer, London. https://doi.org/10.1007/978-1-84996-308-4_6

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