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Cardiopulmonary Bypass Circuit and the Brain

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Brain Protection in Cardiac Surgery

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Abstract

Credit for the development of modern day cardiopulmonary bypass (CPB) is usually given to John Gibbons, who produced a functional heart–lung machine at the Mayo Clinic in the early 1950s.1 The development of the CPB circuit and the field of perfusion in general have been instrumental in the advancement of cardiac surgery over the last 5 decades. However, important neurologic complications were described shortly after the widespread adoption of CPB.2,3 Such central nervous system complications range from subclinical cognitive dysfunction to delirium, to focal stroke, to coma and/or death. An ever-increasing number of clinical and basic research investigations have focused on the impact of CPB on neurologic complications since the 1980s.4–12

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Authors and Affiliations

  1. Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Saxony, Germany

    Michael A. Borger

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  1. Michael A. Borger
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  2. George Djaiani
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  3. Robert A. Baker
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Correspondence to Michael A. Borger .

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Editors and Affiliations

  1. Dept. Cardiothoracic Surgeon, Queen Elizabeth Hospital, Birmingham, B15 2TH, United Kingdom

    Robert S. Bonser

  2. Cardiothoracic Surgery, Beaumont Road 208, Birmingham, B30 1NX, United Kingdom

    Domenico Pagano

  3. Klinik für Herz-, Thorax-,, Transplantations- und Gefäßchirurgie, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Str. 1, Hannover, 30625, Germany

    Axel Haverich

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Borger, M.A., Djaiani, G., Baker, R.A. (2011). Cardiopulmonary Bypass Circuit and the Brain. In: Bonser, R., Pagano, D., Haverich, A. (eds) Brain Protection in Cardiac Surgery. Springer, London. https://doi.org/10.1007/978-1-84996-293-3_2

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