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Bone and Development pp 137–152Cite as

Wnt Signaling in Bone Development

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Part of the book series: Topics in Bone Biology ((TBB,volume 6))

Abstract

This chapter will focus on the role of Wnt signaling in postnatal bone formation and development. Wnts are a large family of 19 secreted carbohydrate- and lipid-modified polypeptides that mediate important biological processes like embryogenesis, organogenesis, and morphogenesis [61, 70, 71, 99]. The proteins bind to a membrane receptor complex composed of a Frizzled (FZD) G-protein coupled receptor and a low-density lipoprotein (LDL) receptor-related protein (LRP) [61, 70, 71]. There are ten different FZDs (1-10) as well as two LRPs (5 and 6), and the binding of Wnt to these receptors activates one of the several intracellular signaling pathways depending on the Wnt, FZD receptor, and the cell type involved [61, 70, 71, 99].

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Authors and Affiliations

  1. Department of Women’s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, PA, USA

    Peter V. N. Bodine

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  1. Peter V. N. Bodine
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Editors and Affiliations

  1. Health Center, University of Connecticut, Farmington Ave. 263, Farmington, 06030-6125, USA

    Felix Bronner

  2. Dept. Biological Sciences, University of Delaware, Newark, 19716, USA

    Mary C. Farach-Carson

  3. IDS Building, MP887, Bone & Joint Research Group, Tremona Road, Southampton, SO16 6YD, United Kingdom

    H.I (Trudy) Roach

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Bodine, P.V.N. (2010). Wnt Signaling in Bone Development. In: Bronner, F., Farach-Carson, M., Roach, H. (eds) Bone and Development. Topics in Bone Biology, vol 6. Springer, London. https://doi.org/10.1007/978-1-84882-822-3_9

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  • DOI: https://doi.org/10.1007/978-1-84882-822-3_9

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  • Online ISBN: 978-1-84882-822-3

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