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BMP Signaling in Skeletogenesis

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Book cover Bone and Development

Part of the book series: Topics in Bone Biology ((TBB,volume 6))

Abstract

Bone is a dynamic tissue that provides skeletal support to the body and is essential in the maintenance of hematopoiesis and calcium homeostasis. Bone development and remodeling are tightly regulated by local paracrine factors and systemic hormones. Bone morphogenic proteins (BMPs) were first identified in the 1960s as proteins with the ability to induce ectopic cartilage and bone formation in vivo [87]. The proteins, however, were not identified until the late 1980s, when several polypeptides with BMP activity were cloned and purified [94]. To date, more than 20 BMP-related proteins have been identified and characterized. These molecules constitute the BMP family of secreted factors and form a subgroup of the transforming growth factor β (TGFβ) superfamily. Extensive studies have shown that BMPs are also essential for nonosteogenic developmental processes. For example, BMPs play roles in dorsal-ventral patterning, specification of the epidermis, development of neuronal phenotypes, tooth development, and regulation of apoptosis [10, 16, 21, 26, 61, 105]. The mechanisms by which BMPs regulate these processes will not be discussed here. This chapter will focus on how BMP signaling and crosstalk between other signaling pathways controls chondrogenic, osteogenic, and adipogenic processes.

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  1. Department of Orthopaedic Surgery Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA

    Kristine D. Estrada & Karen M. Lyons

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  1. Health Center, University of Connecticut, Farmington Ave. 263, Farmington, 06030-6125, USA

    Felix Bronner

  2. Dept. Biological Sciences, University of Delaware, Newark, 19716, USA

    Mary C. Farach-Carson

  3. IDS Building, MP887, Bone & Joint Research Group, Tremona Road, Southampton, SO16 6YD, United Kingdom

    H.I (Trudy) Roach

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© 2010 Springer-Verlag London

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Estrada, K.D., Lyons, K.M. (2010). BMP Signaling in Skeletogenesis. In: Bronner, F., Farach-Carson, M., Roach, H. (eds) Bone and Development. Topics in Bone Biology, vol 6. Springer, London. https://doi.org/10.1007/978-1-84882-822-3_8

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  • DOI: https://doi.org/10.1007/978-1-84882-822-3_8

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-821-6

  • Online ISBN: 978-1-84882-822-3

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