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The Epiphyseal Growth Plate

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Bone and Development

Part of the book series: Topics in Bone Biology ((TBB,volume 6))

Abstract

Bones elongate and children grow tall through the activities of a millimeter thin layer of cells wedged between the epiphyseal head and the diaphyseal shaft of the long bones. The form, function, and regulation of the activities of cells in this thin, transient, cartilaginous plate have fascinated scientists for a long time, and this growth plate is the focus of the studies reviewed in this chapter. A priori, it is important to acknowledge that apart from long bone, epiphyseal plate activity provides the mechanism of growth of almost all the osseous tissues of the human body. Moreover, other bone-related activities such as fracture repair share common pathways with those of chondrocytes located within the growth cartilage. Hence, an understanding of endochondral growth is relevant to bone elongation and repair, as well as systems that are central to cartilage formation, maturation and turnover.

This work was supported by NIH grants DE 010875 (IMS) and DE 013319 (I.M.S.), and DE05262 (HCA).

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Notes

  1. 1.

    The complete PG works of Oliver Wendell Holmes, Sr. by Oliver Wendell Holmes, Sr. (The Physician and Poet) (World eBook Library PGCC Collection) (http://www.WorldLibrary.net).

  2. 2.

    Lectures on the Comparative Anatomy and Physiology of the Vertebrate Animals: Delivered at the Royal College of Surgeons of England, in 1844, published by Longman, Brown, Green, and Longmans, 1846.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA

    H. Clarke Anderson

  2. Department of Orthopaedic Surgery, Jefferson Medical College Thomas Jefferson University, Philadelphia, PA, USA

    Irving M. Shapiro

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  1. H. Clarke Anderson
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  2. Irving M. Shapiro
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  1. Health Center, University of Connecticut, Farmington Ave. 263, Farmington, 06030-6125, USA

    Felix Bronner

  2. Dept. Biological Sciences, University of Delaware, Newark, 19716, USA

    Mary C. Farach-Carson

  3. IDS Building, MP887, Bone & Joint Research Group, Tremona Road, Southampton, SO16 6YD, United Kingdom

    H.I (Trudy) Roach

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Anderson, H.C., Shapiro, I.M. (2010). The Epiphyseal Growth Plate. In: Bronner, F., Farach-Carson, M., Roach, H. (eds) Bone and Development. Topics in Bone Biology, vol 6. Springer, London. https://doi.org/10.1007/978-1-84882-822-3_3

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