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Interrelationship Between Bone and Other Tissues: Brain–Bone Axis and Bone-Adipo Axis

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Bone and Development

Part of the book series: Topics in Bone Biology ((TBB,volume 6))

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Abstract

It has been widely assumed that bone metabolism is controlled mostly by the local environment and does not affect the metabolism of other tissues. In other words, bone was thought to constitute an independent domain from the rest of the body. However, the discovery of neuronal control of bone mass by leptin has shed light on a novel pathway that controls bone metabolism [32]. Furthermore, the recent discovery that osteocalcin modified by OST-PTP regulates glucose metabolism opened a new domain linked to skeletal biology [39]. These unexpected relationships are an outgrowth from the wealth of genetically modified mouse models. Most of these pathways are still far from being fully explored, but the identification of a network between bone and other organs has attracted much attention from basic and clinical scientists.

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Authors and Affiliations

  1. Section of Nephrology, Endocrinology and Metabolism Department of Internal Medicine, Keio University, Tokyo, JPN

    Shu Takeda

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  1. Shu Takeda
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Editors and Affiliations

  1. Health Center, University of Connecticut, Farmington Ave. 263, Farmington, 06030-6125, USA

    Felix Bronner

  2. Dept. Biological Sciences, University of Delaware, Newark, 19716, USA

    Mary C. Farach-Carson

  3. IDS Building, MP887, Bone & Joint Research Group, Tremona Road, Southampton, SO16 6YD, United Kingdom

    H.I (Trudy) Roach

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Takeda, S. (2010). Interrelationship Between Bone and Other Tissues: Brain–Bone Axis and Bone-Adipo Axis. In: Bronner, F., Farach-Carson, M., Roach, H. (eds) Bone and Development. Topics in Bone Biology, vol 6. Springer, London. https://doi.org/10.1007/978-1-84882-822-3_16

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  • DOI: https://doi.org/10.1007/978-1-84882-822-3_16

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