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Development of the Craniofacial Complex

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Bone and Development

Part of the book series: Topics in Bone Biology ((TBB,volume 6))

Abstract

The craniofacial complex comprises the head, face, and oral cavity and is the most distinguishing of all the structures in the human body, imparting unique identities to individuals. Structures of the craniofacial complex, such as the mandible, palate, temporomandibular joint (TMJ), and dentition, each offer valuable paradigms for studying development, structure, and functions. This chapter will provide a background for the succeeding chapter that will compare, in detail, the differences in bone and tooth development. The chapter’s goals are to review the classical and current knowledge of branchial arch development, mandibular and temporo- mandibular joint (TMJ) formation, palatogenesis, and tooth development. Information on defects or disorders that arise from perturbat­ions in genes, their protein products, and relevant signaling pathways is integrated into each section. The overarching goal is to emphasize how the knowledge of fundamental developmental processes can be translated to regenerative approaches targeted at restoring the integrity and function of craniofacial tissues.

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Acknowledgment

The authors acknowledge the excellent editorial assistance provided by Ms. Jeanne Santa Cruz in the preparation of the original manuscript for this chapter. Data described in this chapter were gathered during the course of the following funded research grants: March of Dimes 6-FY06-321 (KKHS), Cleft Palate Foundation (LBR), NIH/NIDCR U24 DE16472 (LBR, KKHS, RDS), NIH/NIDCR T32 DE108380 (RDS), NIH/NIDCR R01 DE013368 and R01 DE019471(RDS), and NIH/NIDCR R01 DE015401 (RH).

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Authors and Affiliations

  1. Department of Biomedical Sciences Baylor College of Dentistry, Texas A&M University Health Science Center, Dallas, TX, USA

    Rena N. D’Souza, L-Bruno Ruest, Robert J. Hinton & Kathy K. H. Svoboda

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  1. Rena N. D’Souza
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  2. L-Bruno Ruest
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  3. Robert J. Hinton
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  4. Kathy K. H. Svoboda
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  1. Health Center, University of Connecticut, Farmington Ave. 263, Farmington, 06030-6125, USA

    Felix Bronner

  2. Dept. Biological Sciences, University of Delaware, Newark, 19716, USA

    Mary C. Farach-Carson

  3. IDS Building, MP887, Bone & Joint Research Group, Tremona Road, Southampton, SO16 6YD, United Kingdom

    H.I (Trudy) Roach

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D’Souza, R.N., Ruest, LB., Hinton, R.J., Svoboda, K.K.H. (2010). Development of the Craniofacial Complex. In: Bronner, F., Farach-Carson, M., Roach, H. (eds) Bone and Development. Topics in Bone Biology, vol 6. Springer, London. https://doi.org/10.1007/978-1-84882-822-3_10

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