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Regenerative Medicine Using Pregnancy-Specific Biological Substances pp 57–65Cite as

Autologous Placental Blood Transfusion for the Therapy of Anemic Neonates

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Abstract

The majority of neonates will have a hematological uncomplicated adaptation to the new circumstances directly after birth. However, premature neonates and neonates in need of a surgical intervention directly after birth are prone to suffer from a mild to severe anemia, which needs to be corrected.

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References

  1. Holland BM, Jones JG, Wardrop CA. Lessons from the anemia of prematurity. Hematol Oncol Clin North Am. 1987;1(3):355-366.

    CAS  PubMed  Google Scholar 

  2. Shannon KM. Anaemia of prematurity: progress and prospects. Am J Pediatr Hematol Oncol. 1990;12(1):14-20.

    Article  CAS  PubMed  Google Scholar 

  3. Shannon KM. Anaemia of prematurity: progress and prospects. Am J Pediatr Hematol Oncol. 1990;12(1):14-20.

    Article  CAS  PubMed  Google Scholar 

  4. Strauss RG. Neonatal anaemia: pathophysiology and treatment. Immunol-Invest. 1995;24(1–2):341-351.

    Article  CAS  PubMed  Google Scholar 

  5. Obladen M, Sachsenweger M, Stahnke M. Blood sampling in very low birth weight infants receiving different levels of intensive care. Eur J Pediatr. 1988;147:399-404.

    Article  CAS  PubMed  Google Scholar 

  6. Rhondeau SM, Christensen RD, Ross MP, Rothstein G, Simmons MA. Responsiveness to recombinant human erythropoietin of marrow erythroid progenitors from infants with the “anaemia of prematurity”. J Pediatr. 1988;112:935-940.

    Article  CAS  PubMed  Google Scholar 

  7. Shannon KM, Naylor GS, Torkildson JC, et al. Circulating erythroid progenitors in the anaemia of prematurity. N Engl J Med. 1987;317:728-733.

    CAS  PubMed  Google Scholar 

  8. Stockman JA. Anaemia of prematurity. Semin Hematol. 1975;12(2):163-173.

    CAS  PubMed  Google Scholar 

  9. Dallman PR. Anaemia of prematurity. Ann Rev Med. 1981;32:143-160.

    Article  CAS  PubMed  Google Scholar 

  10. Bifano EM, Curran TR. Minimizing donor blood exposure in the neonatal intensive care unit. Clin Pediatr. 1995;22(3):657-669.

    CAS  Google Scholar 

  11. Dallman PR. Anaemia of prematurity: the prospects for avoiding blood transfusions by treatment with recombinant human erythropoietin. Adv Pediatr. 1993;40:385-403.

    CAS  PubMed  Google Scholar 

  12. Heese HD, Smith S, Watermeyer S, Dempster WS, Jakubiec L. Prevention of iron deficiency in preterm neonates during infancy. S Afr Med J. 1990;77:339-345.

    CAS  PubMed  Google Scholar 

  13. Shannon KM, Mentzer WC, Abels RI, et al. Recombinant human erythropoietin in the anaemia of prematurity: results of a placebo-controlled pilot study. J Pediatr. 1991;118:949-955.

    Article  CAS  PubMed  Google Scholar 

  14. Maier RF, Obladen M, Scigalla P, et al. The effect of epoetin beta (recombinant human erythropoietin) on the need for transfusion in very-low-birth-weight infants. European Multicentre Erythropoietin Study Group. N Engl J Med. 1994;330(17):1173-1178.

    Article  CAS  PubMed  Google Scholar 

  15. Rabe H, Wacker A, Huelskamp G, et al. A randomised controlled trial of delayed cord clamping in very low birth weight preterm infants. Eur J Pediatr. 2000;159(10):775-777.

    Article  CAS  PubMed  Google Scholar 

  16. Kinmond S, Aitchison TC, Holland BM, Jones JG, Turner TL, Wardrop C. Umbilical cord clamping and preterm infants: a randomized trial. BMJ. 1993;306:172-175. Letters: BMJ (1993) 306:578–579.

    Article  CAS  PubMed  Google Scholar 

  17. Ramasethu J, Luban NLC. Red blood cell transfusion in the newborn. Semin Neonatol. 1999;4:5-16.

    Article  Google Scholar 

  18. Brune T, Garritsen H, Witteler R, et al. Autologous placental blood transfusion for the therapy of anaemic neonates. Biol Neonate. 2002;81:236-243.

    Article  PubMed  Google Scholar 

  19. Johnson JD, Malachowski NC, Sunshine P, Hafleigh EB, Grumet FC. New transfusion program for an intensive care nursery. J Pediatr. 1980;97:806-809.

    Article  CAS  PubMed  Google Scholar 

  20. Spanos T, Karageorga M, Ladis V, Peristeri J, Hatziliami A, Kattamis C. Red cell alloantibodies in patients with thalassemia. Vox Sang. 1990;58:50-55.

    Article  CAS  PubMed  Google Scholar 

  21. Jensen LS, Andersen AJ, Christiansen PM, et al. Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery. Br J Surg. 1992;79:513-516.

    Article  CAS  PubMed  Google Scholar 

  22. Linderkamp O, Nelle M, Kraus M, Zilow EP. The effect of early and late cord-clamping on blood viscosity and other hemorheological parameters in full-term neonates. Acta Pediatr. 1992;81:745-750.

    Article  CAS  Google Scholar 

  23. Usher R, Stephard M, Lind J. The blood volume of the newborn infant and placental transfusion. Acta Pediatr Scand. 1963;52:497-512.

    Article  CAS  Google Scholar 

  24. Yao AC, Moinian M, Lind J. Distribution of blood between infant and placenta after birth. Lancet. 1969;2:871-873.

    Article  CAS  PubMed  Google Scholar 

  25. Wardrop CAJ, Holland BM. The role and vital importance of placental blood to the newborn infant. J Perinat Med. 1995;23:139-143.

    Article  CAS  PubMed  Google Scholar 

  26. Anderson S, Fangman J, Wager G, Uden D. Retrieval of placental blood from the umbilical vein to determine volume, sterility, and presence of clot formation. Am J Dis Child. 1992;146:36-39.

    CAS  PubMed  Google Scholar 

  27. Brossard Y, Van Nifterik J, De Lachaux V, et al. Collection of placental blood with a view to hemopoietic reconstitution. Nouv Rev Fr Hématol. 1990;32:427-442.

    CAS  PubMed  Google Scholar 

  28. Rubinstein P, Rosenfield RE, Adamson JW, Stevens CE. Stored placental blood for unrelated bone marrow reconstitution. Blood. 1993;81(7):1679-1690.

    CAS  PubMed  Google Scholar 

  29. Ballin A, Kenet G, Gutman R, Samara Z, Zakut H, Meytes D. Autologous cord blood transfusion. Acta Paediatr. 1994;83:700-703.

    Article  CAS  PubMed  Google Scholar 

  30. Cairo MS, Wagner EL, Fraser J, et al. Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report. Transfusion. 2005;45(6):856-866.

    Article  PubMed  Google Scholar 

  31. Aroviita P, Teramo K, Hiilesmaa V, Kekomäki R. Cord blood hematopoietic progenitor cell concentration and infant sex. Transfusion. 2005;45(4):613-621.

    Article  PubMed  Google Scholar 

  32. Aufderhaar U, Holzgreve W, Danzer E, Tichelli A, Troeger C, Surbek DV. The impact of intrapartum factors on umbilical cord blood stem cell banking. J Perinat Med. 2003;31(4):317-322.

    Article  PubMed  Google Scholar 

  33. Yao AC, Lind J. Placental Transfusion: A Clinical and Physiological Study. Springfield: Charles C. Thomas; 1982.

    Google Scholar 

  34. Surbek DV, Schönfeld B, Tichelli A, Gratwohl A, Holzgreve W. Optimizing cord blood mononuclear cell yield: a randomized comparison of collection before vs after placenta delivery. Bone Marrow Transplant. 1998;22(3):311-312.

    Article  CAS  PubMed  Google Scholar 

  35. Surbek DV, Aufderhaar U, Holzgreve W. Umbilical cord blood collection for transplantation: which technique should be preferred? Am J Obstet Gynecol. 2000;183(6):1587-1588.

    Article  CAS  PubMed  Google Scholar 

  36. Manegold G, Meyer-Monard S, Tichelli A, Pauli D, Holzgreve W, Troeger C. Cesarean section due to fetal distress increases the number of stem cells in umbilical cord blood. Transfusion. 2008;48(5):871-876.

    Article  PubMed  Google Scholar 

  37. Shlebak AA, Roberts IA, Stevens TA, Syzdlo RM, Goldman JM, Gordon MY. The impact of antenatal and perinatal variables on cord blood haemopoietic stem/progenitor cell yield available for transplantation. Br J Haematol. 1998;103(4):1167-1171.

    Article  CAS  PubMed  Google Scholar 

  38. Paxson CL. Collection and use of autologous foetal blood. Am J Obstet Gynecol. 1979;134:708-710.

    PubMed  Google Scholar 

  39. Brandes JM, Roth EF, Berk PD, et al. Collection and preservation of human placental blood. Transfusion. 1983;23:325-327.

    Article  CAS  PubMed  Google Scholar 

  40. Bifano EM, Dracker RA, Lorah K, Palit A. Collection and 28-day storage of human placental blood. Pediatr Res. 1994;36:90-94.

    Article  CAS  PubMed  Google Scholar 

  41. Abel M, Elsinger W, Sutor AH, Gregorio G, Peukert W. Untersuchungen zur transfusionsmedizinischen Validität von autologem Plazentablut. Infusionstherapie. 1985;12(4):197-200.

    CAS  Google Scholar 

  42. Bifano EM, Palit A, Lorah K, Dracker R. Neonatal autologous transfusion: a potential form of hemotherapy. Pediatr Res. 1990/1991;29:273A.

    Google Scholar 

  43. Garritsen HSP, Brune T, Louwen F, et al. Transfusion of stored autologous red cells from cord blood: collection and preparation with extended storage medium (SAG-M). Transfusion Med. 2003;13:303-310.

    Article  CAS  Google Scholar 

  44. Horn S, Mazor D, Zmora E, Meyerstein N. Storage-induced changes in human newborn red cells. Transfusion. 1987;27:411-414.

    Article  CAS  PubMed  Google Scholar 

  45. Golden SM, Petit N, Mapes T, Davis SE, Monaghan WP. Bacteriologic assessment of autologous cord blood for ­neonatal transfusion. Am J Obstet Gynecol. 1984;149:907-908.

    CAS  PubMed  Google Scholar 

  46. Peltonen T. Placental transfusion – advantage and disadvantage. Eur J Pediatr. 198 1;13(7):141-146.

    Google Scholar 

  47. Eichler E, Schaible T, Richter E, et al. Cord blood as a source of autologous RBCs for transfusion to preterm infants. Transfusion. 2000;40:1111-1117.

    Article  CAS  PubMed  Google Scholar 

  48. Strauss RG. Autologous transfusions for neonates using placental blood. A cautionary note. Am J Dis Child. 1992;146:21-22.

    CAS  PubMed  Google Scholar 

  49. Jimenez L, Smalls S, Ignar R. Use of PCR analysis for detecting low levels of bacteria and mold contamination in pharmaceutical samples. J Microbial Methods. 2000;41(3):259-265.

    Article  CAS  Google Scholar 

  50. Petit T, Gluckman E, Carosella E, Brossard Y, Brison O, Socie G. A highly sensitive polymerase chain reaction method reveals the ubiquitous presence of matemal cells in human umbilical cord blood. Exp Hematol. 1995;23:1601-1605.

    CAS  PubMed  Google Scholar 

  51. Lo YMD, Lo ESF, Watson N, et al. Two-way cell traffic between mother and foetus: biologic and clinical implications. Blood. 1996;88(11):4390-4395.

    CAS  PubMed  Google Scholar 

  52. Brune T, Koch HG, Pluempe U, Coenen-Worch V, Harms E, Louwen F. Effect of pathological perinatal conditions on the maternofetal transfer of mononuclear cells. Fetal Diagn Ther. 2002;17:110-114.

    Article  PubMed  Google Scholar 

  53. Pollack M, Kapoor N, Sorell M, et al. DR-positive matemal engrafted T cells in a severe combined immunodeficiency patient without graft-versus-host disease. Transplantation. 1980;30(5):331-334.

    Article  CAS  PubMed  Google Scholar 

  54. Appleton AL, Curtis A, Wilkes J, Cant AJ. Differentiation of materno-foetal GvHD from Omenn’s syndrome in pre-BMT patients with severe combined immunodeficiency: case report. Bone Marrow Transplant. 1994;14:157-159.

    CAS  PubMed  Google Scholar 

  55. Olding LB, Benirschke K, Oldstone MBA. Inhibition of lymphocytes from human adults by lymphocytes from human newborns. Clin Immunol Immunopathol. 1974;3(1):79-89.

    Article  CAS  PubMed  Google Scholar 

  56. Adinoifi M. Inhibition of mitosis of maternal lymphocytes by foetal cells. Lancet. 1976;10:97.

    Article  Google Scholar 

  57. Jamaer D. The use of the double cell population phenomena of the Gel test in posttransfusion complications and after bone marrow transplantation. Present and the Future of The Gel Test, Presentations and Posters from the First International Symposium, Montreux 17–18 March 1993, 1994 by DiaMed AG, 1785 Cressiers/Morat Switzerland, 88–91.

    Google Scholar 

  58. Brune T, Garritsen H, Hentschel R, Louwen F, Harms E, Jorch G. Efficacy, recovery, and safety of RBCs from autologous placental blood: clinical experience in 52 newborns. Transfusion. 2003;43(9):1210-1216.

    Article  PubMed  Google Scholar 

  59. Brandes JM, Timov-Tritsch I, Suchov P. Autologous heparinized placental blood transfusion for the treatment of the anemic monozygotic twin. Presented to the Haifa Obstetrical Society; 1977; Haifa, Israel.

    Google Scholar 

  60. Taguchi T, Suita S, Nakamura M, et al. The efficacy of autologous cord-blood transfusions in neonatal surgical patients. J Pediatr Surg. 2003;38(4):604-607.

    Article  PubMed  Google Scholar 

  61. Khodabux CM, von Lindern JS, van Hilten JA, Scherjon S, Walther FJ, Brand A. A clinical study on the feasibility of autologous cord blood transfusion for anemia of prematurity. Transfusion. 2008;48(8):1634-1643.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Zentrum für Kinderheilkunde, Perinatologie, University Children’s Hospital, Universitätsklinikum Magdeburg, Gerhard-Hauptmannstr. 35, D-39108, Magdeburg, Germany

    Thomas Brune

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  1. Thomas Brune
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  2. F. Louwen
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  3. C. Troeger
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  4. W. Holzgreve
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  5. H. S. P. Garritsen
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Correspondence to Thomas Brune .

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Editors and Affiliations

  1. Advanced Medical Research Inst., B.P.Poddar Hospital, Vidyasagar Hospital, Kolkata, India

    Niranjan Bhattacharya

  2. Dept. Obstetrics & Gynaecology, Boston University Medical Centre, E. Concord Street 85, Boston, 02118, Massachusetts, USA

    Phillip Stubblefield

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Brune, T., Louwen, F., Troeger, C., Holzgreve, W., Garritsen, H.S.P. (2011). Autologous Placental Blood Transfusion for the Therapy of Anemic Neonates. In: Bhattacharya, N., Stubblefield, P. (eds) Regenerative Medicine Using Pregnancy-Specific Biological Substances. Springer, London. https://doi.org/10.1007/978-1-84882-718-9_6

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  • DOI: https://doi.org/10.1007/978-1-84882-718-9_6

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