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Use of Cord Blood in Regenerative Medicine

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Regenerative Medicine Using Pregnancy-Specific Biological Substances

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Abstract

It is estimated that up to 128 million individuals might benefit from regenerative medicine therapy, or almost one in three individuals in the USA. Multipotent stem cells are easily available in large numbers in umbilical cord blood (CB), and may be the best alternative to embryonic stem (ES) cells. CB stem cells are capable of giving rise to hematopoietic, epithelial, endothelial, and neural tissues both in vitro and in vivo. Thus, CB stem cells are amenable to treat a wide variety of diseases including cardiovascular, ophthalmic, orthopedic, neurological, and endocrine diseases. Examples of these usages currently in clinical trials include applications that affect the nervous and endocrine system, including cerebral palsy and type I diabetes. The numbers of such individuals affected with each of these diseases are estimated to be 10,000 annually. A summary of the initial beneficial results from such clinical trials using autologous CB stem cells will be presented.

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Abbreviations

CB:

Cord blood

CP:

Cerebral palsy

T1D:

Type I diabetes.

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Acknowledgments

The funding by The Jerome Lejeune Foundation is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Immunobiology, The University of Arizona, 1656 E. Mabel, MRB 221, Tucson, AZ, 85724, USA

    David T. Harris

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  1. David T. Harris
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Correspondence to David T. Harris .

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  1. Advanced Medical Research Inst., B.P.Poddar Hospital, Vidyasagar Hospital, Kolkata, India

    Niranjan Bhattacharya

  2. Dept. Obstetrics & Gynaecology, Boston University Medical Centre, E. Concord Street 85, Boston, 02118, Massachusetts, USA

    Phillip Stubblefield

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Harris, D.T. (2011). Use of Cord Blood in Regenerative Medicine. In: Bhattacharya, N., Stubblefield, P. (eds) Regenerative Medicine Using Pregnancy-Specific Biological Substances. Springer, London. https://doi.org/10.1007/978-1-84882-718-9_32

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  • DOI: https://doi.org/10.1007/978-1-84882-718-9_32

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