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Umbilical Cord-Derived Mesenchymal Stem Cells

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Regenerative Medicine Using Pregnancy-Specific Biological Substances

Abstract

Hematopoiesis is a time- and site-dependent event ­during ontogeny of vertebrates. The first wave of hematopoietic activity appears in the ventral blood islands of the yolk sac, where primitive nucleated erythrocytes are formed to control the oxygen demand of the growing embryo. A second wave of primitive hematopoiesis (aorta-gonads-mesonephros, AGM region) is continued by a shift to the fetal liver where production of all hematopoietic cells is initiated. From near birth until the end of life, hematopoiesis resides in the bone marrow. Thus, embryonic, fetal, and adult hematopoieses are associated with a common stem cell, which, during each migratory event, reaches the specific milieu that is permissive for the programmed and sequential expression of the different forms of hematopoiesis.1

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Authors and Affiliations

  1. TCA Cellular Therapy, LLC, 101 E. Fairway Dr., Suite 514, Covington, LA, 70433, USA

    Jose J. Minguell (Scientific Director)

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  1. Jose J. Minguell
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Correspondence to Jose J. Minguell .

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Editors and Affiliations

  1. Advanced Medical Research Inst., B.P.Poddar Hospital, Vidyasagar Hospital, Kolkata, India

    Niranjan Bhattacharya

  2. Dept. Obstetrics & Gynaecology, Boston University Medical Centre, E. Concord Street 85, Boston, 02118, Massachusetts, USA

    Phillip Stubblefield

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© 2011 Springer London

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Minguell, J.J. (2011). Umbilical Cord-Derived Mesenchymal Stem Cells. In: Bhattacharya, N., Stubblefield, P. (eds) Regenerative Medicine Using Pregnancy-Specific Biological Substances. Springer, London. https://doi.org/10.1007/978-1-84882-718-9_25

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  • DOI: https://doi.org/10.1007/978-1-84882-718-9_25

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