Skip to main content
SpringerLink
Log in
Book cover

Regenerative Medicine Using Pregnancy-Specific Biological Substances pp 169–174Cite as

Placental Umbilical Cord Blood Transfusion for Stem Cell Therapy in Neurological Diseases

  • Chapter
  • First Online:

  • 973 Accesses

Abstract

Human nervous system is a highly differentiated and specialized tissue that minimizes its potential for regeneration and self-renewal in response to injury. Conventional attempt at the repair of adult brain and spinal cord by pharmacological therapy has been largely unsuccessful and had very limited clinical impact. Yet developmental and acquired neurological disabilities contribute to significant socio-economic burden in any community.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Olesen J, Leonardi M. The burden of brain disease in Europe. Eur J Neurol. 2003;10:471-477.

    Article  CAS  PubMed  Google Scholar 

  2. Mezey E, Chandross KJ. Bone marrow: a possible alternative source of cells in the adult nervous system. Eur J Pharmacol. 2000;405:297-302.

    Article  CAS  PubMed  Google Scholar 

  3. Priller J, Persons DA, Kleitt FF, et al. Neurogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo. J Cell Biol. 2001;155:733-738.

    Article  CAS  PubMed  Google Scholar 

  4. Roy NS, Nakano T, Keyoung HM, et al. Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord. Nat Biotechnol. 2004;22:297-305.

    Article  CAS  PubMed  Google Scholar 

  5. Sanai N, Tramontin AD, Quinones-Hinojosa A, et al. Unique astrocyte ribbon in adult human brain contains neural stem cells but lack chain migration. Nature. 2004;427:479-494.

    Article  Google Scholar 

  6. Cairo MS, Wagner JE. Placental and/or umbilical cord blood: an alternative source of haematopoietic stem cells for transplantation. Blood. 1997;90:4665-4678.

    CAS  PubMed  Google Scholar 

  7. Bicknese AR, Goodwin HS, Quinn CO, et al. Human umbilical cord blood cells can be induced to express markers for neurons and glia. Cell Transplant. 2002;11:261-264.

    PubMed  Google Scholar 

  8. Zhao ZM, Lu SH, Zhang QJ, et al. The preliminary study on in vitro differentiation of human umbilical cord blood cells into neural cells. Zhonghua Xue Ye Xue Za Zhi. 2003;24:484-487.

    PubMed  Google Scholar 

  9. Fu YS, Shih YT, Cheng YC, Min MY. Transformation of human umbilical mesenchymal cells into neurons in vitro. J Biomed Sci. 2004;11:652-660.

    Article  CAS  PubMed  Google Scholar 

  10. Lee OK, Kuo TK, Wei-Ming Chen, et al. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood. 2004;103:1669-1675.

    Article  CAS  PubMed  Google Scholar 

  11. Jang YK, Park JJ, Lee MC, et al. Retinoic acid-mediated induction of neurons and glia from human umbilical cord-derived haematopoietic stem cells. J Neurosci Res. 2004;75:573-584.

    Article  CAS  PubMed  Google Scholar 

  12. Bhattacharya N, Mukherjee K, Chettri MK, et al. A study report of 174 units of placental umbilical whole cord blood transfusion in 62 patients as a rich source of fetal haemoglobin therapy in different indications of blood transfusion. Clin Exp Obstet Gynaecol. 2001;28:47-52.

    CAS  Google Scholar 

  13. Bhattacharya N. Placental umbilical cord blood transfusion: a new method for treatment of patients with diabetes and microalbuminuria in the background of anemia. Clin Exp Obstet Gynaecol. 2006;33:164-168.

    CAS  Google Scholar 

  14. Chaudhuri A, Hollands P, Bhattacharya N. Placental umbilical cord blood transfusion in acute ischaemic stroke. Med Hypotheses. 2007;69:1267-1271.

    Article  PubMed  Google Scholar 

  15. Fukuda H, Masuzaki H, Ishimaru T. Interleukin-6 and interleukin-1 receptor antagonist in amniotic fluid and cord blood in patients with pre-term, premature rupture of the membranes. Int J Gynaecol Obstet. 2002;77:123-129.

    Article  CAS  PubMed  Google Scholar 

  16. Vendrame M, Gemma C, de Mesquita D, et al. Anti-inflammatory effects of human cord blood cells in a rat model of stroke. Stem Cells Dev. 2005;14:595-604.

    Article  CAS  PubMed  Google Scholar 

  17. Naruse K, Hamada Y, Nakashima E, et al. Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy. Diabetes. 2005;54:1823-1828.

    Article  CAS  PubMed  Google Scholar 

  18. Chen SH, Chang FM, Tsai YC, et al. Infusion of human umbilical cord blood protects against cerebral ischaemia and damage during heatstroke in the rat. Exp Neurol. 2006;199:67-76.

    Article  CAS  PubMed  Google Scholar 

  19. Burt RK, Loh Y, Cohen B, et al. Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing remitting multiple sclerosis: a phase I/II study. Lancet Neurol. 2009;8:244-253.

    Article  CAS  PubMed  Google Scholar 

  20. Okamoto S, Kang Y-J, Brechtel CW, et al. HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell cycle withdrawal and G1 arrest. Cell Stem Cell. 2007;1:230-236.

    Article  CAS  PubMed  Google Scholar 

  21. Britten N. Stem cell doctors bring a blind girl into the light. The Daily Telegraph March 5, 2009;7.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Essex Centre for Neurological Sciences, Romford, Queen’s Hospital, Rom Valley Way, Romford, RM7 0AG, UK

    Abhijit Chaudhuri

Authors
  1. Abhijit Chaudhuri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Niranjan Bhattacharya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Abhijit Chaudhuri .

Editor information

Editors and Affiliations

  1. Advanced Medical Research Inst., B.P.Poddar Hospital, Vidyasagar Hospital, Kolkata, India

    Niranjan Bhattacharya

  2. Dept. Obstetrics & Gynaecology, Boston University Medical Centre, E. Concord Street 85, Boston, 02118, Massachusetts, USA

    Phillip Stubblefield

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer London

About this chapter

Cite this chapter

Chaudhuri, A., Bhattacharya, N. (2011). Placental Umbilical Cord Blood Transfusion for Stem Cell Therapy in Neurological Diseases. In: Bhattacharya, N., Stubblefield, P. (eds) Regenerative Medicine Using Pregnancy-Specific Biological Substances. Springer, London. https://doi.org/10.1007/978-1-84882-718-9_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-84882-718-9_17

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-717-2

  • Online ISBN: 978-1-84882-718-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation