Abstract
Bone matrix is generated and organized according to the direction of mechanical force, e.g., following muscular contraction, impact with supporting surface and gravity. Cellular mechanotransduction from outer milieu, which is a biochemical expression of the external mechanical force via cellular pathways, determines the three dimensional structure of bone following interactions between its generation and resorption, i.e., remodeling and repair process by interaction between osteoblast and osteoclast activities. Of the latter two type of cells the osteoblast governs this complex process, partially following the external mechanical effect. Therefore understanding and recognizing of the nature of the cellular pathways in osteoblast mechnotransduction might reveal new therapeutic methods in numerous disabling bone pathologies due to the loss of bone mass or the loss of its structural integrity.
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Rosenberg, N., Soudry, M. (2016). Experimental In Vitro Methods for Research of Mechanotransduction in Human Osteoblasts. In: Poitout, D. (eds) Biomechanics and Biomaterials in Orthopedics. Springer, London. https://doi.org/10.1007/978-1-84882-664-9_26
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DOI: https://doi.org/10.1007/978-1-84882-664-9_26
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