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Epigenetic Aspects of Chronic Diseases pp 205–215Cite as

Targeting Histone Deacetylases in Chronic Obstructive Pulmonary Disease

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Abstract

Histone deacetylases (HDAC) play a critical role in gene suppression through the recruitment of corepressor proteins to switch off gene transcription, which is activated by histone acetylation. Activated inflammatory genes are suppressed by HDAC2. Corticosteroids recruit HDAC2 to switch off inflammatory genes. HDAC2 may therefore be a target for the development of anti-inflammatory treatments, particularly in diseases where there is active corticosteroid resistance, as in chronic obstructive pulmonary disease (COPD).

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Authors and Affiliations

  1. National Heart and Lung Institute, Imperial College London, London, UK

    Peter J. Barnes

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  1. Peter J. Barnes
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Editors and Affiliations

  1. , General Hospital, University of Southampton, Southampton, SO16 6YD, United Kingdom

    Helmtrud I. Roach

  2. Health Center, Dept. Pharmacology, University of Connecticut, Farmington Ave. 263, Farmington, 06030-6125, Connecticut, USA

    Felix Bronner

  3. Developmental Origins Health and Disease, University of Southampton, Southampton, SO16 6YD, United Kingdom

    Richard O.C. Oreffo

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Barnes, P.J. (2011). Targeting Histone Deacetylases in Chronic Obstructive Pulmonary Disease. In: Roach, H., Bronner, F., Oreffo, R. (eds) Epigenetic Aspects of Chronic Diseases. Springer, London. https://doi.org/10.1007/978-1-84882-644-1_14

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