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Infections of Bones and Joints

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Book cover Children's Orthopaedics and Fractures

Abstract

In order to produce disease, parasites must be able to invade host tissues, multiply and spread, and produce toxic substances. The ability to produce disease is known as pathogenicity, and the comparative pathogenicity of different organisms is expressed as virulence. Very small numbers of virulent organisms are able to produce disease, whereas larger numbers of less virulent organisms are required. The invasiveness of microorganisms is not clearly related to their toxic properties, but enzymes produced by them allow both spread by tissue dissolution and protection from host phagocytes.

Infection must be considered as a struggle between two organisms … the parasite and its host. This brings about adaptations on both sides.

(Elie Metschnikoff, 1891)

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Author information

Authors and Affiliations

  1. Orthopaedic Department, Pediatric Centre Olgahospital, Stuttgart, Germany

    Klaus Parsch

  2. Department of Surgery, The University of Sydney, Sydney, NSW, Australia

    Sydney Nade

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  1. Klaus Parsch
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  2. Sydney Nade
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Editor information

Editors and Affiliations

  1. Nuffield Orthopaedic Centre, University of Oxford, Windmill Road, Oxford, OX3 7LD, United Kingdom

    Michael Benson

  2. Sick Children, Great Ormond Street Hospital for, Greater Ormond Street, London, WC1N 3JH, United Kingdom

    John Fixsen

  3. Orthopaedic Hospital, Princess Margaret Rose, Frogston Road West 41-43, Edinburgh, EH10 7ED, United Kingdom

    Malcolm Macnicol

  4. Orthopädie, Olgahospital, Bismarckstr. 8, Stuttgart, 70176, Germany

    Klausdieter Parsch

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Parsch, K., Nade, S. (2010). Infections of Bones and Joints. In: Benson, M., Fixsen, J., Macnicol, M., Parsch, K. (eds) Children's Orthopaedics and Fractures. Springer, London. https://doi.org/10.1007/978-1-84882-611-3_10

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  • DOI: https://doi.org/10.1007/978-1-84882-611-3_10

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