Abstract
Anomalous origin of the left coronary artery from the pulmonary trunk usually presents in early infancy with congestive cardiac failure due to ischemic myocardial dysfunction. The diagnosis can usually be made by parasternal short axis sections of the great arteries. The most characteristic finding is reversed flow in the left coronary artery demonstrated by color flow Doppler. Usually the anomalous coronary artery connects to the pulmonary trunk at one of the sinuses, but in some cases the connection may be to the more distal pulmonary arteries. A less common presentation of this condition is in late childhood or early adult life, usually with left ventricular dysfunction and mitral regurgitation. There is almost always reversed blood flow in the left coronary artery representing a left to right shunt from the right coronary artery into the pulmonary trunk.
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References
Douglas PS, Fiolkoski J, Berko B, Reichek N. Echocardiographic visualization of coronary artery anatomy in the adult. J Am Coll Cardiol. 1988;11(3):565–71.
Block PJ, Popp RL. Detecting and excluding significant left main coronary artery narrowing by echocardiography. Am J Cardiol. 1985;55(8):937–40.
Vered Z, Katz M, Rath S, Har-Zahav Y, Battler A, Benjamin P, et al. Two-dimensional echocardiographic analysis of proximal left main coronary artery in humans. Am Heart J. 1986;112(5):972–6.
Iliceto S, Marangelli V, Memmola C, Rizzon P. Transesophageal Doppler echocardiography evaluation of coronary blood flow velocity in baseline conditions and during dipyridamole-induced coronary vasodilation. Circulation. 1991;83(1):61–9.
Yamagishi M, Miyatake K, Beppu S, Kumon K, Suzuki S, Tanaka N, et al. Assessment of coronary blood flow by transesophageal two-dimensional pulsed Doppler echocardiography. Am J Cardiol. 1988;62(9):641–4.
Yoshida K, Yoshikawa J, Hozumi T, Yamaura Y, Akasaka T, Fukaya T, et al. Detection of left main coronary artery stenosis by transesophageal color Doppler and two-dimensional echocardiography. Circulation. 1990;81(4):1271–6.
Waller BF, Pinkerton CA, Slack JD. Intravascular ultrasound: a histological study of vessels during life. The new ‘gold standard’ for vascular imaging. Circulation. 1992;85(6):2305–10.
Yock PG, Fitzgerald PJ, Linker DT, Angelsen BA. Intravascular ultrasound guidance for catheter-based coronary interventions. J Am Coll Cardiol. 1991;17(6 Suppl B):39B–45.
Nissen SE, Gurley JC, Grines CL, Booth DC, McClure R, Berk M, et al. Intravascular ultrasound assessment of lumen size and wall morphology in normal subjects and patients with coronary artery disease. Circulation. 1991;84(3):1087–99.
Voros S, Rinehart S, Qian Z, Vazquez G, Anderson H, Murrieta L, et al. Prospective validation of standardized, 3-dimensional, quantitative coronary computed tomographic plaque measurements using radiofrequency backscatter intravascular ultrasound as reference standard in intermediate coronary arterial lesions results from the ATLANTA (Assessment of Tissue Characteristics, Lesion Morphology, and Hemodynamics by Angiography with Fractional Flow Reserve, Intravascular Ultrasound and Virtual Histology, and Noninvasive Computed Tomography in Atherosclerotic Plaques) I Study. JACC Cardiovasc Interv. 2011;4(2):198–208.
Hiro T, Kimura T, Morimoto T, Miyauchi K, Nakagawa Y, Yamagishi M, et al. Effect of intensive statin therapy on regression of coronary atherosclerosis in patients with acute coronary syndrome: a multicenter randomized trial evaluated by volumetric intravascular ultrasound using pitavastatin versus atorvastatin (JAPAN-ACS [Japan assessment of pitavastatin and atorvastatin in acute coronary syndrome] study). J Am Coll Cardiol. 2009;54(4):293–302.
Buda AJ, Zotz RJ, Gallagher KP. Characterization of the functional border zone around regionally ischemic myocardium using circumferential flow-function maps. J Am Coll Cardiol. 1986;8(1):150–8.
Horowitz RS, Morganroth J, Parrotto C, Chen CC, Soffer J, Pauletto FJ. Immediate diagnosis of acute myocardial infarction by two-dimensional echocardiography. Circulation. 1982;65(2):323–9.
Kaul S, Pandian NG, Gillam LD, Newell JB, Okada RD, Weyman AE. Contrast echocardiography in acute myocardial ischemia. III. An in vivo comparison of the extent of abnormal wall motion with the area at risk for necrosis. J Am Coll Cardiol. 1986;7(2):383–92.
Engelsen DJ, Gorgels AP, Cheriex EC, De Muinck ED, Ophuis AJ, Dassen WR, et al. Value of the electrocardiogram in localising the occlusion site in the left anterior descending coronary artery in acute anterior myocardial infarction. J Am Coll Cardiol. 1999;34:389–95.
O’Sullivan CA, Ramzy IS, Duncan A, Li W, Henein MY. The effect of the Q wave infarct on left ventricular electromechanical function. Int J Cardiol. 2003;92(1):71–6.
D’Arcy B, Nanda NC. Two-dimensional echocardiographic features of right ventricular infarction. Circulation. 1982;65(1):167–73.
Ramzy IS, O’Sullivan CA, Lam YY, Dancy M, Tei C, Henein MY. Right ventricular stunning in inferior myocardial infarction. Int J Cardiol. 2009;136(3):294–9. Epub Aug 8, 2008.
Pasternack RC, Braunwald E, Sobel BE. Acute myocardial infarction. In: Braunwald E, editor. Heart disease. Philadelphia: W.B. Saunders; 1992. p. 1255–60.
Visser CA, Kan G, David GK, Lie KI, Durrer D. Echocardiographic-cineangiographic correlation in detecting left ventricular aneurysm: a prospective study of 422 patients. Am J Cardiol. 1982;50(2):337–41.
Catherwood E, Mintz GS, Kotler MN, Parry WR, Segal BL. Two-dimensional echocardiographic recognition of left ventricular pseudoaneurysm. Circulation. 1980;62(2):294–303.
Barrett MJ, Charuzi Y, Corday E. Ventricular aneurysm: cross-sectional echocardiographic approach. Am J Cardiol. 1980;46(7):1133–7.
Matsumoto M, Watanabe F, Goto A, Hamano Y, Yasui K, Minamino T, et al. Left ventricular aneurysm and the prediction of left ventricular enlargement studied by two-dimensional echocardiography: quantitative assessment of aneurysm size in relation to clinical course. Circulation. 1985;72(2):280–6.
Jordan RA, Miller RD, Edwards JE, Parker RL. Thromboembolism in acute and healed myocardial infarction: intracardiac mural thrombosis. Circulation. 1952;6:1–6.
Rueda B, Panidis IP, Gonzales R, McDonough M. Left ventricular pseudoaneurysm: detection and postoperative follow-up by color Doppler echocardiography. Am Heart J. 1990;120(4):990–2.
Drobac M, Gilbert B, Howard R, Baigrie R, Rakowski H. Ventricular septal defect after myocardial infarction: diagnosis by two-dimensional contrast echocardiography. Circulation. 1983;67(2):335–41.
Smyllie JH, Sutherland GR, Geuskens R, Dawkins K, Conway N, Roelandt JR. Doppler color flow mapping in the diagnosis of ventricular septal rupture and acute mitral regurgitation after myocardial infarction. J Am Coll Cardiol. 1990;15(6):1449–55.
Chirillo F, Totis O, Cavarzerani A, Bruni A, Risica G, Cuzzato V. Transesophageal echocardiographic findings in partial and complete papillary muscle rupture complicating acute myocardial infarction. Cardiology. 1992;81(1):54–8.
Koenig K, Kasper W, Hofmann T, Meinertz T, Just H. TransÂesophageal echocardiography for diagnosis of rupture of the ventricular septum or left ventricular papillary muscle during acute myocardial infarction. Am J Cardiol. 1987;59(4):362.
Stoddard MF, Keedy DL, Kupersmith J. Transesophageal echocardiographic diagnosis of papillary muscle rupture complicating acute myocardial infarction. Am Heart J. 1990;120(3):690–2.
Barzilai B, Gessler Jr C, Perez JE, Schaab C, Jaffe AS. Significance of Doppler-detected mitral regurgitation in acute myocardial infarction. Am J Cardiol. 1988;61(4):220–3.
Alam M, Thorstrand C, Rosenhamer G. Mitral regurgitation following first-time acute myocardial infarction – early and late findings by Doppler echocardiography. Clin Cardiol. 1993;16(1):30–4.
Izumi S, Miyatake K, Beppu S, Park YD, Nagata S, Kinoshita N, et al. Mechanism of mitral regurgitation in patients with myocardial infarction: a study using real-time two-dimensional Doppler flow imaging and echocardiography. Circulation. 1987;76(4):777–85.
Feldman T, Cilingiroglu M. Percutaneous leaflet repair and annuloplasty for mitral regurgitation. J Am Coll Cardiol. 2011;57(5):529–37.
Franzen O, Baldus S, Rudolph V, Meyer S, Knap M, Koschyk D, et al. Acute outcomes of MitraClip therapy for mitral regurgitation in high-surgical-risk patients: emphasis on adverse valve morphology and severe left ventricular dysfunction. Eur Heart J. 2010;31(11):1373–81. Epub Mar 10, 2010.
Foster E, Wasserman HS, Gray W, Homma S, Di Tullio MR, Rodriguez L, et al. Quantitative assessment of severity of mitral regurgitation by serial echocardiography in a multicenter clinical trial of percutaneous mitral valve repair. Am J Cardiol. 2007;100(10):1577–83.
Swaans MJ, Van den Branden BJ, Van der Heyden JA, Post MC, Rensing BJ, Eefting FD, et al. Three-dimensional transoesophageal echocardiography in a patient undergoing percutaneous mitral valve repair using the edge-to-edge clip technique. Eur J Echocardiogr. 2009;10(8):982–3. Epub Aug 4, 2009.
Benedetto U, Melina G, Roscitano A, Fiorani B, Capuano F, Sclafani G, et al. Does combined mitral valve surgery improve survival when compared to revascularization alone in patients with ischemic mitral regurgitation? A meta-analysis on 2479 patients. J Cardiovasc Med (Hagerstown). 2009;10(2):109–14.
Appleton CP, Hatle LK, Popp RL. Relation of transmitral flow velocity patterns to left ventricular diastolic function: new insights from a combined hemodynamic and Doppler echocardiographic study. J Am Coll Cardiol. 1988;12(2):426–40.
Rossvoll O, Hatle LK. Pulmonary venous flow velocities recorded by transthoracic Doppler ultrasound: relation to left ventricular diastolic pressures. J Am Coll Cardiol. 1993;21(7):1687–96.
Bolognese L, Sarasso G, Bongo AS, Rossi L, Aralda D, Piccinino C, et al. Dipyridamole echocardiography test. A new tool for detecting jeopardized myocardium after thrombolytic therapy. Circulation. 1991;84(3):1100–6.
Jaarsma W, Visser CA, Kupper AJ, Res JC, van Eenige MJ, Roos JP. Usefulness of two-dimensional exercise echocardiography shortly after myocardial infarction. Am J Cardiol. 1986;57(1):86–90.
Berthe C, Pierard LA, Hiernaux M, Trotteur G, Lempereur P, Carlier J, et al. Predicting the extent and location of coronary artery disease in acute myocardial infarction by echocardiography during dobutamine infusion. Am J Cardiol. 1986;58(13):1167–72.
Keller MW, Glasheen W, Smucker ML, Burwell LR, Watson DD, Kaul S. Myocardial contrast echocardiography in humans. II. Assessment of coronary blood flow reserve. J Am Coll Cardiol. 1988;12(4):925–34.
Sakata Y, Kodama K, Adachi T, Lim YJ, Ishikura F, Fuji H, et al. Comparison of myocardial contrast echocardiography and coronary angiography for assessing the acute protective effects of collateral recruitment during occlusion of the left anterior descending coronary artery at the time of elective angioplasty. Am J Cardiol. 1997;79(10):1329–33.
Picano E. Stress echocardiography. From pathophysiological toy to diagnostic tool. Circulation. 1992;85(4):1604–12.
Marwick TH, Nemec JJ, Pashkow FJ, Stewart WJ, Salcedo EE. Accuracy and limitations of exercise echocardiography in a routine clinical setting. J Am Coll Cardiol. 1992;19(1):74–81.
Picano E, Parodi O, Lattanzi F. Comparison of dipyridamole-echocardiography test and exercise thallium-201 for diagnosis of coronary artery disease. Am J Noninv Cardiol. 1989;3:85–92.
Sawada SG, Ryan T, Conley MJ, Corya BC, Feigenbaum H, Armstrong WF. Prognostic value of a normal exercise echocardiogram. Am Heart J. 1990;120(1):49–55.
Henein MY, Gibson DG. Normal long axis function. Heart. 1999;81(2):111–3.
Henein M, Lindqvist P, Francis D, Morner S, Waldenstrom A, Kazzam E. Tissue Doppler analysis of age-dependency in diastolic ventricular behaviour and filling: a cross-sectional study of healthy hearts (the Umea General Population Heart Study). Eur Heart J. 2002;23(2):162–71.
Henein MY, Gibson DG. Long axis function in disease. Heart. 1999;81(3):229–31.
Mishra MB, Lythall DA, Chambers JB. A comparison of wall motion analysis and systolic left ventricular long axis function during dobutamine stress echocardiography. Eur Heart J. 2002;23(7):579–85.
von Bibra H, Tuchnitz A, Klein A, Schneider-Eicke J, Schömig A, Schwaiger M. Regional diastolic function by pulsed Doppler myocardial mapping for the detection of left ventricular ischemia during pharmacologic stress testing: a comparison with stress echocardiography and perfusion scintigraphy. J Am Coll Cardiol. 2000;36(2):444–52.
O’Sullivan CA, Henein MY, Sutton R, Coats AJ, Sutton GC, Gibson DG. Abnormal ventricular activation and repolarisation during dobutamine stress echocardiography in coronary artery disease. Heart. 1998;79(5):468–73.
Duncan AM, O’Sullivan CA, Carr-White GS, Gibson DG, Henein MY. Long axis electromechanics during dobutamine stress in patients with coronary artery disease and left ventricular dysfunction. Heart. 2001;86(4):397–404.
Duncan AM, Francis DP, Henein MY, Gibson DG. Limitation of cardiac output by total isovolumic time during pharmacologic stress in patients with dilated cardiomyopathy: activation-mediated effects of left bundle branch block and coronary artery disease. J Am Coll Cardiol. 2003;41(1):121–8.
Duncan AM, Francis DP, Gibson DG, Henein MY. Differentiation of ischemic from nonischemic cardiomyopathy during dobutamine stress by left ventricular long-axis function: additional effect of left bundle-branch block. Circulation. 2003;108(10):1214–20. Epub 2003 Aug 25.
Henein MY, Patel DJ, Fox KM, Gibson DG. Asynchronous left ventricular wall motion in unstable angina. Int J Cardiol. 1997;59(1):37–45.
Pierard LA, De Landsheere CM, Berthe C, Rigo P, Kulbertus HE. Identification of viable myocardium by echocardiography during dobutamine infusion in patients with myocardial infarction after thrombolytic therapy: comparison with positron emission tomography. J Am Coll Cardiol. 1990;15(5):1021–31.
Senior R, Lahiri A. Role of dobutamine echocardiography in detection of myocardial viability for predicting outcome after revascularization in ischemic cardiomyopathy. J Am Soc Echocardiogr. 2001;14(3):240–8.
Senior R. Role of contrast echocardiography for the assessment of left ventricular function. Echocardiography. 1999;16(7, Pt 2):747–52.
Meza MF, Ramee S, Collins T, Stapleton D, Milani RV, Murgo JP, et al. Knowledge of perfusion and contractile reserve improves the predictive value of recovery of regional myocardial function postrevascularization: a study using the combination of myocardial contrast echocardiography and dobutamine echocardiography. Circulation. 1997;96(10):3459–65.
Duncan AM, O’Sullivan C, Gibson DG, Henein M. The effect of dobutamine stress on left ventricular long axis and early diastolic filling in patients with coronary artery disease. J Am Coll Cardiol. 2001;37:433A.
Henein MY, Amadi A, O’Sullivan C, Coats A, Gibson DG. ACE inhibitors unmask in coordinate diastolic wall motion in restrictive left ventricular disease. Heart. 1996;76(4):326–31.
Brecker SJ, Xiao HB, Sparrow J, Gibson DG. Effects of dual-Âchamber pacing with short atrioventricular delay in dilated cardiomyopathy. Lancet. 1992;340(8831):1308–12.
Henein MY, Priestley K, Davarashvili T, Buller N, Gibson DG. Early changes in left ventricular subendocardial function after Âsuccessful coronary angioplasty. Br Heart J. 1993;69(6):501–6.
Koh TW, Carr-White GS, DeSouza AC, Ferdinand FD, Pepper JR, Gibson DG. Effect of coronary occlusion on left ventricular function with and without collateral supply during beating heart coronary artery surgery. Heart. 1999;81(3):285–91.
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Henein, M.Y., Sheppard, M., Pepper, J.R., Rigby, M. (2012). Coronary Artery Disease. In: Henein, M. (eds) Clinical Echocardiography. Springer, London. https://doi.org/10.1007/978-1-84882-521-5_7
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DOI: https://doi.org/10.1007/978-1-84882-521-5_7
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